Epithelial cell kinetics in oral leukoplakia

Warnakuiasuriya, K.A.A.S.; MacDonald, D.G.

doi:10.1111/j.1600-0714.1995.tb01159.x

Cited by 21 publications

(13 citation statements)

References 16 publications

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“…[7114] Many authors have stated that one of the important characteristics of the neoplastic transformation of a steady-state epithelial system is the alteration of growth rate, commonly reflected as increased cell proliferation. [7273]…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical evaluation of oral epithelial dysplasia using cyclin-D1, p27 and p63 expression as predictors of malignant transformation

et al. 2013

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Objective:To evaluate the degree of expression of cyclin-D1, p27 and p63 in mild, moderate and severe dysplasia using immunohistochemical evaluation in order to illustrate their prognostic value and attempt to propose a molecular grading system for oral epithelial dysplasia.Materials and Methods:The analysis included thirty cases of mild, moderate and severe dysplasia from Department of Oral and Maxillofacial Pathology, Saveetha Dental College, Chennai after a critical review of the Hematoxylin and Eosin (H and E) stained sections. They were subjected to immunohistochemical evaluation using the markers cyclin-D1, p27 and p63. The assessment of the expression based on staining intensity and distribution of immunohistochemical staining of the various markers was analyzed followed by statistical analysis.Results:A highly significant increase in the expression of cyclin-D1 (P < 0.000) and p63 (P < 0.001) and a moderately significant decrease in the expression of p27 (P < 0.012) with the increasing severity of dysplasia was observed in our study.Conclusions:The result of our research affirms the fact that the increase in the expression of markers of cell cycle regulators such as cyclin D1, decrease in the expression of cell cycle inhibitors like p27 and increased expression of p63 in parallel with the increasing severity of dysplasia, emphasizes the use of immunohistochemical markers cyclin D1, p27 and p63 as prognostic markers for better understanding the behaviour of these potentially malignant disorders aiming towards proposing a molecular grading system for oral epithelial dysplasia to enable timely management prior to their possible malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical evaluation of oral epithelial dysplasia using cyclin-D1, p27 and p63 expression as predictors of malignant transformation

et al. 2013

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“…Ki‐67 was initially included as a guide to determine the level of proliferation. Increased cell proliferation has been reported to be characteristic in malignant progression and to have predictive and prognostic significance (19, 20). Other reports however have not confirmed such a relationship (21).…”

Section: Discussionmentioning

confidence: 99%

Aberrant expression of p53, p16INK4a and Ki-67 as basic biomarker for malignant progression of oral leukoplakias

Nasser

Flechtenmacher

Holzinger

et al. 2011

Journal of Oral Pathology &Amp; Medicine

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“…In recognized precancerous states of the oral mucosa such as oral leukoplakia, epithelial cell proliferation is nearly double that of the normal oral epithelium (Warnakulasuriya & MacDonald 1995). The finding of a significantly higher state of cell proliferation in OLP compared with the normal oral mucosa raises the question whether this feature could be an important early step in some cases of OLP that eventually transform to malignancy.…”

Section: Discussionmentioning

confidence: 99%

Epithelial cell proliferation in oral lichen planus

et al. 2002

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Although the pathogenesis of oral lichen planus (OLP) is not clear, a small proportion of cases with OLP are reported to transform to cancer. We examined the epithelial cell proliferation status of OLP to relate the labelling index to microscopic features surveyed routinely in pathology. Mucosal biopsies obtained from 44 cases diagnosed with OLP with an intact oral epithelium and 10 normal control specimens from Japanese subjects were immunohistochemically stained with MIB and p53 antibodies. The Ki67 labelling index (LI) was significantly higher in OLP compared with normal controls. A particularly large number of OLP lesions (64%) were p53 positive. No association was, however, found with p53 expression and the Ki67 LI. Atrophic and flat epithelia had a quantitatively higher LI, which did not significantly differ from acanthotic biopsies. Increased cell proliferation in OLP is likely to be a secondary phenomenon due to the damage inflicted on keratinocytes by infiltrating mononuclear cells in the submucosa.

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Epithelial cell kinetics in oral leukoplakia

Cited by 21 publications

References 16 publications

Immunohistochemical evaluation of oral epithelial dysplasia using cyclin-D1, p27 and p63 expression as predictors of malignant transformation

Immunohistochemical evaluation of oral epithelial dysplasia using cyclin-D1, p27 and p63 expression as predictors of malignant transformation

Aberrant expression of p53, p16INK4a and Ki-67 as basic biomarker for malignant progression of oral leukoplakias

Epithelial cell proliferation in oral lichen planus

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