Epithelial atrophy, fibrosis and vascularity correlation with epithelial dysplasia in oral submucous fibrosis, a prospective study

Kapoor, Ruchika; Sansare, Kaustubh; Tamgadge, Sandhya; Karjodkar, Freny; Mehra, Archana; Mishra, Isha; Desai, Rajiv S.; Sinha, Anuradha

doi:10.4103/jmau.jmau_36_20

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…A potential cause of OSF is the progressive loss of diseased mucosal blood vessels, which can lead to epithelial atrophy [ 49 ]. Therefore, vasodilators are considered effective for the treatment of OSF.…”

Section: Discussionmentioning

confidence: 99%

Drug treatment for oral submucous fibrosis: an update

Chen,

Xie,

Guo

2023

BMC Oral Health

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Objective The aim of this review is to evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF). Materials and methods We conducted a comprehensive electronic search on PubMed, Web of Science, and Cochrane Library databases for articles related to OSF patients treated with medications from December 2011 to September 2022. GRADE system was used to evaluate the evidence quality. The reporting of the systematic review is in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The main outcomes were the improvement of maximum mouth opening, burning sensation, cheek flexibility, and tongue protrusion. Results Twenty-nine randomized controlled trials (RCTs), five clinical trials (CCTs) were included, and the use of drugs for OSF treatment were evaluated. Drugs like steroids, hyaluronidase, pentoxifylline, lycopene, curcumin, dpirulina, aloe vera, omega3, oxitard, allicin, colchicine have been used. It was found that drugs with evidence high quality were salvia miltiorrhiza combined with triamcinolone acetonide, lycopene, pentoxifylline, curcumin, and aloe vera, and those with evidence moderate quality were allicin, colchicine, omega 3, and oxitard. Conclusion Based on the results of our comprehensive analysis, for long-term treatment, we found lycopene with low side effects, whereas for relieving the symptoms of severe burning sensation, aloe vera is the most effective. Although the recent review has made some progress, drug therapy for OSF remains unclear, and more high-quality RCTs are needed to identify better treatments for OSF.

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Section: Discussionmentioning

confidence: 99%

Drug treatment for oral submucous fibrosis: an update

Chen,

Xie,

Guo

2023

BMC Oral Health

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“…Oral submucous fibrosis has been considered a precancerous status that begins with oral fibrous tissue lesions and epithelial atrophy, develops mucosal sclerosis, and finally results in trismus, and interferes with the functions of the oral cavity. 22 , 23 , 24 There are several risk factors speculated to induce oral submucous fibrosis, such as genetic factors, areca, natural killer cells, and trace elements, but direct evidence was lacking. 25 , 26 Some studies have focused on the identification of effect biomarkers correlated with the onset and development of oral submucous fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Accumulated X-ray irradiation induces miR-187-5p upregulation mediating fibrotic buccal mucosal fibroblasts activities via DKK2

Zheng¹,

Xu²

2023

Journal of Dental Sciences

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“…A potential cause of OSF is the progressive loss of diseased mucosal blood vessels, which can lead to epithelial atrophy [19]. Therefore, vasodilators are considered effective for the treatment of OSF.…”

Section: Peripheral Vasodilatorsmentioning

confidence: 99%

Drug treatment for oral submucous fibrosis: a systematic review

Chen

Guo

2023

Preprint

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Objective The aim of this review is to evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF). Materials and methods We searched a comprehensive electronic search on PubMed, Web of Science, and Cochrane Library databases for articles related to OSF patients treated with medications from December 2011 to September 2022. GRADE system was used to evaluate the evidence quality. Results Twenty-nine randomized controlled trials (RCTs), six non-RCT studies were included, and the use of drugs for OSF treatment were evaluated. The main outcomes were improvement in mouth opening, burning sensation, cheek flexibility, and tongue protrusion. Drugs like steroids, hyaluronidase, pentoxifylline, lycopene, curcumin, dpirulina, aloe vera, omega3, oxitard, allicin, colchicine have been used. It was found that drugs with evidence high quality were SMI combined with triamcinolone acetonide, lycopene, pentoxifylline, curcumin, and aloe vera, and those with evidence moderate quality were allicin, colchicine, omega 3, and oxitard. Conclusion Based on the results of our comprehensive analysis, for long-term treatment, we found lycopene with low side effects, whereas for relieving the symptoms of severe burning sensation, aloe vera is the most effective. Although the resent review has made some progress, drug therapy for OSF remains unclear, and more high-quality RCTs are needed to identify better treatments for OSF.

show abstract

Epithelial atrophy, fibrosis and vascularity correlation with epithelial dysplasia in oral submucous fibrosis, a prospective study

Cited by 4 publications

References 19 publications

Drug treatment for oral submucous fibrosis: an update

Drug treatment for oral submucous fibrosis: an update

Accumulated X-ray irradiation induces miR-187-5p upregulation mediating fibrotic buccal mucosal fibroblasts activities via DKK2

Drug treatment for oral submucous fibrosis: a systematic review

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