Epithelial and stromal alterations in prostate after cypermethrin administration in adult albino rats (histological and biochemical study)

Hashem, Hala E.; El-Haleem, Manal R. Abd; Abass, Marwa

doi:10.1016/j.tice.2015.04.007

Cited by 9 publications

(4 citation statements)

References 46 publications

(54 reference statements)

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“…Research reports in the last 5 years indicate that exposure to pyrethroids resulted in delayed Leydig cell development, [ 24 ] endocrine disruption, reproductive dysfunction, [ 25‐27 ] , and alterations in the epithelial and stromal cells of the prostate. [ 28 ] We demonstrated that exposure to allethrin caused reproductive dysfunction in male rats and disruption of expression of genes involved in germ cell production. [ 29‐31 ] The majority of the studies conducted for many decades focused on the effect of a single pyrethroid using doses that are not relevant to human exposure settings.…”

Section: Introductionmentioning

confidence: 99%

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Ravula

Yenugu

2020

J Biochem & Molecular Tox

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Humans are exposed to pyrethroid‐based pesticides through agricultural produce. In this study, male Wistar rats were orally treated for 9 to 12 months with a mixture of pyrethroids that is equivalent to one‐fifth (high dose; HD) or one‐twenty fifth (low dose; LD) of the amount of pyrethroids present in the cereals and rice consumed by an average Indian. In rats treated for 9 months, the spermatogenesis‐associated genes Abp, Ar, Cd9, Dax1, Dazap1, Ddx3y, Gdnf, Gfra1, Grth, Inhb, Ovol1, P1, Plzf, Pygo2, Scf, Tgfb1, Tp1, Tp2, and Vim1 were downregulated in both LD and HD groups. In rats treated for 12 months Gdnf, Hsf2, Inhb, Tgfb1, Thy1, and Ybx2 expression was downregulated in both LD and HD groups. Steroidogenesis‐associated genes 17‐β‐Hsd, Gata4, Hmgcr, Hmgcs1, Pde4b, and Tspo gene expression were reduced in both LD‐ and HD‐treated groups treated for 9 months. In 12‐month‐treated rats, Creb1 expression decreased in both LD and HD groups. The epigenetic reprogramming‐associated genes, Dnmt1, Dnmt3a, Dnmt3b, Hdac10, Hp1bp3, Kat3a Kat3b, Mch2ta, Ncoa7, and Sirt1 were downregulated in both HD and LD groups of 9‐months‐treated rats. In rats treated for 12 months, Hdac10, Mch2ta, Ncoa7, and Sirt1 messenger RNA levels decreased in both the HD and LD groups. Thus, we demonstrate that long‐term exposure to a mixture of pyrethroids caused aberrations in the transcriptome of factors involved in sperm production and development.

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Section: Introductionmentioning

confidence: 99%

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Ravula

Yenugu

2020

J Biochem & Molecular Tox

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“…Similar ultrastructural findings were seen after various chemical injury exposures in adult male albino rats. Authors suggested that these degenerative epithelial changes could be attributed to oxidative stress which was marked by the significant decrease in the prostatic glutathione level [34] .…”

Section: Discussionmentioning

confidence: 99%

The effect of Zinc Nanoparticles on Adult rat Prostate gland and the Possible Protective role of Rutin: histological and biochemical study

Hashem

Amin²

2021

Egyptian Journal of Histology

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Introduction: Zinc nanoparticles (ZnNPs) usage is evolving in different industrial and medical applications. However, recently nanoparticles were reported for their harmful effects. Rutin is a flavonoid that presents in plants, many veg¬etables, and fruits. It is considered a strong antioxidant. Aim: To detect the effect of ZnNPs on the adult rat prostate gland and evaluating the possible protective effect of Rutin. Materials and Methods: Fifty adult male albino rats were divided into four groups: Group I (control), Group II (ZnNPs group) rats received ZnNPs in a dose of 100 mg/kg via oral gavage feeding needle for 28 days. Group III (Rutin group): rats received rutin in a dose of 50 mg/kg via oral gavage feeding needle for 28 days. Group IV (ZnNPs-Rutin group): rats received Zn NPs and rutin at a dose and route as groups II, III. After 28 days, rats were weighed; blood samples were collected then sacrificed. The prostate glands were dissected and processed for histological (LM and EM), immunohistochemical, and biochemical studies with morphometric analysis. Results: Light microscopic examination of Group II sections revealed degeneration of acini, vacuolation, and pyknotic nuclei of their lining cells. A highly statistically significant increase in thickness of the fibromuscular stroma (P ˂ 0.001) in Masson Trichrome sections and a highly statistically significant increase (P ˂ 0.001) in positive PCNA immunoreactions in the nuclei of epithelial cells were detected. Ultrathin sections showed vacuolations in acinar cells cytoplasm. Those findings are associated with a highly significant increase in Malondialdehyde, and Prostatic specific antigen. On the contrary, Group IV sections displayed restoration of prostatic acini arrangement with areas of hyperplasia and a statistically decrease in MDA, PSA. Conclusion: These findings evidenced that Rutin had a natural protective role against ZnNPs induced prostatic cell injury in rats.

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“…The effects of CP can also extend to the prostate. Decreased activity of enzymes as well as degenerative changes in the prostatic epithelium of rats followed by changes in their stroma appear to occur due to oxidative stress caused by CP (HASHEMA et al, 2015). …”

Section: Spermatogenesis and Hormonal Controlmentioning

confidence: 98%

“…Studies report that CP exposure results in a significant adverse effect on the male reproductive system of rodents, indicated by decrease in seminal quantity and quality, deformed spermatozoa, low levels of testosterone, as well as decrease in the fertility of these animals (YOUSEF et al, 2003;AHMAD et al, 2008;HASHEMA et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cypermethrin exposure and effects on the reproductive male system: a literature review

2017

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The use of pesticides has become a major problem of public and environmental health in the world and especially in Brazil, which consumes tons of these compounds every year since the 50s. Among the pesticides, cypermethrin is an admittedly widely used synthetic pyrethroid due to its broad spectrum of action, resulting in its massive use in the agricultural sector. Epidemiological data show a considerable increase in the incidence of diseases in the male reproductive tract among them, the decline of sperm quality in various regions of the world, with consequent increase in demand for assisted reproduction services and increased incidences of cryptorchidism, hypospadias and testicular tumors. In recent years, researchers have shown that some pyrethroid compounds are capable of interfering with the endocrine system of animal species, including human being and therefore can be considered as endocrine disrupters. They can result in a deviation from normal homeostatic control or reproduction by interfering with the synthesis, secretion, transport, binding, action or elimination of natural hormones. It has been reported that endocrine disruptors may be responsible for the decline in sperm density and increase in hypospadias, cryptorchidism and testicular Revinter, v. 10, n. 03, p. 18-38, out. 2017. P á g i n a19 | 38 cancer in humans. In this sense, experimental studies have shown that cypermethrin acts indirectly on male gametogenesis, interfering with the synthesis of testosterone.Other disorders induced by cypermethrin are also reported, as structural changes of the seminiferous tubules, morphological changes in germ cells and sperm as well as a reduction in their count in semen. This paper aims to demonstrate aspects of endocrine disruption in the male reproductive system related to cypermethrin exposure, using data from animal studies (in vivo) and biological samples of human beings (in vitro). células germinativas e espermatozoides, bem como uma redução na sua contagem no sêmen. Este trabalho tem como objetivo demonstrar aspectos da desregulação endócrina no sistema reprodutor masculino relacionados à exposição à cipermetrina, utilizando dados de estudos animais (in vivo) e amostras biológicas de seres humanos (in vitro). Palavras

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Epithelial and stromal alterations in prostate after cypermethrin administration in adult albino rats (histological and biochemical study)

Cited by 9 publications

References 46 publications

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

The effect of Zinc Nanoparticles on Adult rat Prostate gland and the Possible Protective role of Rutin: histological and biochemical study

Cypermethrin exposure and effects on the reproductive male system: a literature review

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