Epistaxis and gross haematuria with severe thrombocytopaenia associated with influenza vaccination

Almohammadi, Abdullah; Lundin, Michael; Abro, Calvin; Hrinczenko, Borys

doi:10.1136/bcr-2019-229423

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Immune-complexes of antibodies against influenza virus are also capable of activating platelets through an interaction with the Fc-ϒIIA receptor present on the platelet surface, leading to thrombocytopenia in a humanized mouse model. These findings, combined with reported influenza vaccine induced ITP, point to a link between influenza virus-specific adaptive immunity and thrombocytopenia [ 193 , 194 , 195 ].…”

Section: Resultsmentioning

confidence: 76%

Thrombocytopenia in Virus Infections

Raadsen

Toit

Langerak

et al. 2021

JCM

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Thrombocytopenia, which signifies a low platelet count usually below 150 × 109/L, is a common finding following or during many viral infections. In clinical medicine, mild thrombocytopenia, combined with lymphopenia in a patient with signs and symptoms of an infectious disease, raises the suspicion of a viral infection. This phenomenon is classically attributed to platelet consumption due to inflammation-induced coagulation, sequestration from the circulation by phagocytosis and hypersplenism, and impaired platelet production due to defective megakaryopoiesis or cytokine-induced myelosuppression. All these mechanisms, while plausible and supported by substantial evidence, regard platelets as passive bystanders during viral infection. However, platelets are increasingly recognized as active players in the (antiviral) immune response and have been shown to interact with cells of the innate and adaptive immune system as well as directly with viruses. These findings can be of interest both for understanding the pathogenesis of viral infectious diseases and predicting outcome. In this review, we will summarize and discuss the literature currently available on various mechanisms within the relationship between thrombocytopenia and virus infections.

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Section: Resultsmentioning

confidence: 76%

Thrombocytopenia in Virus Infections

Raadsen

Toit

Langerak

et al. 2021

JCM

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“…It is critical to underscore that ITP following the influenza vaccine is rare: per the Vaccine Adverse Events Reporting System (VAERS) database [6], there were only 133 cases reported between 1990 and early 2022 in the United States [6]; additionally, there are only a handful of case reports in the literature [7][8][9][10][11][12][13][14]. These reports largely document experiences similar to our own, specifically about onset (the condition typically develops about four to seven days following vaccination).…”

Section: Discussionmentioning

confidence: 99%

Acute Immune Thrombocytopenia Following Influenza Vaccination in a Patient With Untreated Helicobacter pylori Infection

Asiimwe,

Kahlon

2023

Cureus

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A 70-year-old man with previously normal comprehensive blood counts (CBCs) was referred to our hospital for acute thrombocytopenia. Following a negative workup for secondary causes, we diagnosed immune thrombocytopenia (ITP). Aside from the influenza vaccine administered six days before presentation, there was no discernable precipitant on history. His only risk factor for ITP was untreated Helicobacter pylori diagnosed over two months prior. With treatment, the patient's platelets normalized within three days. ITP following influenza vaccination has been documented in the literature and reported to regulatory bodies. Our case indicates that individuals with untreated H. pylori infection might be particularly vulnerable to such occurrences.

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“…However, whether viral infection, lymphocyte count at first diagnosis, antiplatelet antibody, megakaryocyte count and other factors are related to prognosis, there are currently different opinions in domestic and foreign research. [28][29][30][31] The newly diagnosed ALC is related to the immunity of the child. Lyu et al 32 showed that the absolute value of newly diagnosed lymphocytes is an independent factor leading to chronic ITP in children.…”

Section: Discussionmentioning

confidence: 99%