Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): Relationships to eating- and personality-related psychopathology

Catechol-O-methyltransferase activity in erythrocytes from patients with eating disorders

“…These findings corroborate the growing evidence about the role of COMT on ED. Moreover, these results are in line with several studies that pointed out the high-activity allele of COMT, Val158, as risk factor for BN [1,11,12]. However, as mentioned before, some studies also showed an association between the low activity allele of COMT, Met158 and ED, whereas other studies found no association.…”

“…The results were controversial: some studies appointed the higher activity allele as risk factor for AN [9,10] or BN [1,11,12], whereas other group of studies pointed out the lower activity COMT allele [13,14]. Some studies did not find association between this polymorphism and AN [1,2,[15][16][17][18] and BN [10].…”

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

“…In agreement, A1-allele carriers display higher levels of childhood antisocial behavior, bipolar disorder with low anxiety, impulsivity, novelty/stimulus seeking, aggression, antisocial/borderline traits, faster habituation to positive feedback (decoupling behavior from experience), and substance abuse/dependence but also adaptive traits such as extraversion, behavioral activation, low depression or harm avoidance, and improved cognitive performance (Noble et al, 1998;Bartrés-Faz et al, 2002;Eisenberg et al, 2007;Hoenicka et al, 2007;Ponce et al, 2008 ;Althaus et al, 2009;Esposito-Smythers et al, 2009;Ponce et al, 2009;Barskiĭ et al, 2010;Nemoda et al, 2010;Smillie et al, 2010;Stelzel et al, 2010;Thaler et al, 2012;Kazantseva et al, 2011;Lu et al, 2012;Zai et al, 2012;Wang et al, 2013aWang et al, , 2014. A1-carriers also showed significantly lower levels of risk for depression and higher engagement bias towards positive social stimuli, thus evincing a more stable and higher DA functioning (Elovainio et al, 2007;Gong et al, 2013).…”

“…Behavioral activation was increased in males with either the Val/A1 or Met/A2 genotype, whereas Met/A1 and Val/A2 carriers showed normal BAS scores (Reuter et al, 2006). Val/A1 carriers also showed higher levels of BAS fun seeking, stimulus seeking (i.e., novelty seeking or quest for excitement), and behavioral impulsivity compared to Met/A1 carriers but these differences did not reach significance (Reuter et al, 2006;Thaler et al, 2012). In fact, the Met/A1 carriers showed the lowest scores on all measures of BAS and impulsivity compared to the other genotype groups (Met/A2, Val/A1, Val/A2) (Reuter et al, 2006).…”

An Evolutionary Genetic Perspective of Eating Disorders

“…The co-occurrence of two distinct phenotypes because of the linkage disequilibrium of mutations located in different genes has been suggested in few studies on EDs. Epistatic interactions have been found between the serotonin transporter and the norepinephrine transporter genes [138] as well as the monoamine oxidase A genes in AN [139], and between the dopaminergic genes (DRD2/DRD4 and CMOT/DAT1), influencing both eating-and personality-related psychopathology [140].…”