Episodic syndromes of childhood associated with migraine

Gelfand, Amy A.

doi:10.1097/wco.0000000000000558

Cited by 24 publications

(11 citation statements)

References 54 publications

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“…There is evidence in the literature supporting a brain‐gut connection 21 . This review further corroborates this association by providing evidence of shared pathophysiological features, such as alterations in serotonergic signaling 35–43 and autonomic dysfunction, 20,22–24,26–28,30,31 and overlapping symptomatology between migraine, 1,4,5,7,11,14,18,44–53 and GI disorders including gastroparesis, functional dyspepsia, and cyclic vomiting syndrome, often presenting as comorbidities in either condition 7,10,11,54–58 …”

Section: Pathophysiological Similarities Between Gi Comorbidities and Migrainesupporting

confidence: 69%

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A link between gastrointestinal disorders and migraine: Insights into the gut–brain connection

et al. 2021

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Section: Pathophysiological Similarities Between Gi Comorbidities and Migrainesupporting

confidence: 69%

“…18,28 Migraine is also a frequent comorbidity present in individuals with CVS, including children. 56,57 In a retrospective study by Fleisher et…”

Section: Cvs and Migrainementioning

confidence: 99%

A link between gastrointestinal disorders and migraine: Insights into the gut–brain connection

et al. 2021

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“…There are some indications that babies with colic become children at increased risk for recurrent abdominal pain or become adults who have more frequent FGIDs or mood disorders than a control healthy infant population without colic 7 . It has been suggested that infants with infantile colic are at increased risk of developing migraine 8 . However, well-designed long-term, prospective, observational studies are needed to endorse the few reports on possible associations between infantile colic and later health outcomes.…”

Section: What Is Infantile Colic?mentioning

confidence: 99%

Recent advances in understanding and managing infantile colic

et al. 2018

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A newborn brings joy to the family. Crying belongs to the spectrum of normal behaviour of young infants. However, although it occurs in about 20% of all infants, unsoothable and persistent crying in young infants distresses the family, although it is usually benign. The aetiology of infantile colic remains unknown, although an unbalanced gastro-intestinal microbiome, increased intestinal permeability, and chronic inflammation are involved, as well as behavioural factors, including over- and under-stimulation. It is a challenge for healthcare professionals to decide when organic disease needs to be excluded. Parental stress is a reason for babies to cry more, inducing a vicious cycle. Therefore, parental reassurance with explanatory guidance is the cornerstone of management. The placebo effect is estimated to be as high as 50%. If an intervention is felt to be necessary to offer further support to the baby and family, it is important to choose the options for which there is some efficacy without adverse effects. There is evidence that some specific probiotic strains such as Lactobacillus reuteri DSM 19378, especially in breastfed infants, are effective. However, there are also promising data for some synbiotics and/or killed or tyndallized bacteria, as well as substances decreasing intestinal permeability. Formula management with extensive and/or partial hydrolysates may also bring relief. But, above all, offering parental support remains imperative.

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“…Patients with migraine are likely to have a medical history of infant colic, and an infant with colic tends to have parents with migraine [12, 13]. And infant colic is considered to be early expression of migraine [14]. TTH and migraine exhibit similar pathogenic mechanisms, resulting from the dysfunction of nociceptive pain processing [15].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Infant Colic and Migraine as well as Tension-Type Headache: A Meta-Analysis

Zhang¹,

Zhang²,

Sang³

et al. 2019

Pain Research and Management

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Background. Infant colic is a common benign disease during early infancy. Migraine and tension-type headache (TTH) are the most common primary headache forms among pediatric population. Several studies have investigated the incidence of infant colic in patients with migraine and TTH. The meta-analysis was to assess the relationship between infant colic and migraine as well as TTH. Methods. PubMed, Web of Science, and Cochrane Library were searched until August 16, 2018, for potential studies. Data were extracted by two independent authors and analyzed using RevMan 5.2 software. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine the association between infant colic and migraine as well as TTH, respectively. Results. A total of 148 studies were found, and 7 studies were finally included. A higher incidence of colic during infancy was revealed in migraine patients than controls (P=0.05, OR: 2.51, 95% CI: 1.32–4.77) and TTH subjects (P=0.02, OR: 0.33, 95% CI: 0.13–0.86), respectively. And no significances were found between TTHs with controls (P=0.51, OR: 1.17, 95% CI: 0.73–1.89). Conclusion. This meta-analysis indicated that migraine was associated with increased incidence of infantile colic history, but TTH incidence was not relevant with the incidence of infantile colic history.

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Episodic syndromes of childhood associated with migraine

Abstract: Episodic syndromes are considered to be early life expressions of migraine in the developing brain. Additional research is needed to determine, which acute and preventive treatments are the most effective in managing these disorders.

Cited by 24 publications

References 54 publications

A link between gastrointestinal disorders and migraine: Insights into the gut–brain connection

A link between gastrointestinal disorders and migraine: Insights into the gut–brain connection

Recent advances in understanding and managing infantile colic

The Relationship between Infant Colic and Migraine as well as Tension-Type Headache: A Meta-Analysis

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