Episcleral brachytherapy for uveal melanoma: analysis of 136 cases

García-Álvarez, C.; Saornil, María A.; López-Lara, Francisco; Almaraz, Ana; Muñoz, Mauricio Pastor; Frutos-Baraja, Jesús María de; Muiños, Y

doi:10.1007/s12094-012-0807-1

Cited by 12 publications

(8 citation statements)

References 18 publications

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“…In 9.0% of patients, enucleation was necessary with regards to the pain resulting from post-irradiation complications. The obtained results are comparable with those reported by other authors [29,38]. Jampol et al .…”

Section: Discussionsupporting

confidence: 92%

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Outcomes of I-125 brachytherapy for uveal melanomas depending on irradiation dose applied to the tumor apex – a single institution study

Kowal¹,

Markiewicz²,

Dębicka-Kumela³

et al. 2018

jcb

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PurposeThe aim of the study was an evaluation of I-125 brachytherapy patients with uveal melanoma with special consideration for the relationship of the treatment results and the irradiation dose applied to the tumor apex.Material and methodsMedical records of 344 adults with uveal melanoma treated with I-125 brachytherapy in the Department of Ophthalmology and Ocular Oncology of the Jagiellonian University, Medical College in Cracow, Poland were retrospectively analyzed. The study was conducted between 2003 and 2012, and the study group was divided into two subgroups depending on the irradiation dose applied to the top of the tumor: 80 Gy to 100 Gy (n = 177) and 100 Gy to 120 Gy (n = 167).ResultsIt was found that the height of the tumor and the largest diameter of the tumor base decreased with every consecutive follow-up measurement and differed significantly in all comparisons (p < 0.0001). No significant correlation between frequency of complications was found between both study groups (χ2 = 0.27; p = 0.6067). The correlation between survival and the irradiation dose as applied to the tumor top was statistically irrelevant (χ2 = 0.44; p = 0.5084). A logistic regression model showed that patient survival depended on the largest diameter of the base and the height of tumor (p = 0.0216), and the risk of death was larger as these dimensions increased (IR, 1.17). An increase of the largest diameter of the base by 1 mm meant a 17% increase in chances of death. In 13.4% of cases, an enucleation was necessary.ConclusionsThe treatment of choroidal melanomas with I-125 iodine isotope brachytherapy is an efficient and recommended method of treatment and in many cases, an alternative to the enucleation of an eyeball.

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Section: Discussionsupporting

confidence: 92%

“…In the COMS studies carried out by Demirci et al . and Garcia-Alvarez et al ., the decrease of the size of the uveal melanoma was on a similar level [24,25,28,29]. Additionally, Demirci et al .…”

Section: Discussionmentioning

confidence: 87%

Outcomes of I-125 brachytherapy for uveal melanomas depending on irradiation dose applied to the tumor apex – a single institution study

Kowal¹,

Markiewicz²,

Dębicka-Kumela³

et al. 2018

jcb

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“…Оптическая нейропатия (ОНП) развивается у 14,6-46% больных после облучения ОА с 125 I [18,23,24,40,43] и у 8,2-16,1% -после облучения ОА с 106 Ru [34,41,44]. Механизм развития лучевой ОНП до конца не распознан.…”

Section: результаты и обсужденияunclassified

Late complications of choroidal melanoma brachytherapy and possibility of their prevention

Brovkina¹,

Khionidi²

2018

Vestn. oftal'mol.

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“…I125 episcleral brachytherapy in uveal melanoma is effective in tumor control, allowing preservation of the eye and useful visual function for the majority of patients [34].…”

Section: B Surgery: Resection/enucleationmentioning

confidence: 99%

Update in Ocular Melanoma

Bustuoabad¹,

Speroni²,

Irarrázabal³

2013

Melanoma - From Early Detection to Treatment

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Episcleral brachytherapy for uveal melanoma: analysis of 136 cases

Abstract: I-125 EB is effective in tumour control, allowing preservation of the eye and useful visual function for the majority of patients.

Cited by 12 publications

References 18 publications

Outcomes of I-125 brachytherapy for uveal melanomas depending on irradiation dose applied to the tumor apex – a single institution study

Outcomes of I-125 brachytherapy for uveal melanomas depending on irradiation dose applied to the tumor apex – a single institution study

Late complications of choroidal melanoma brachytherapy and possibility of their prevention

Update in Ocular Melanoma

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