Epiretinal membrane in diabetes mellitus patients screened by nonmydriatic fundus camera

Knyazer, Boris; Schachter, Orit; Plakht, Ygal; Serlin, Yonatan; Smolar, Jenna; Belfair, Nadav; Lifshitz, Tova; Levy, Jaime

doi:10.1016/j.jcjo.2015.09.016

Cited by 12 publications

(5 citation statements)

References 38 publications

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“…Knyazer et al found a significant association between ERM to age, cataract surgery, and diabetic retinopathy. 14 Knyazer et al also reported a prevalence of ERM at 6.5% in type 2 diabetes mellitus, and Mitchell et al reported a prevalence of 11% in patients with DR.…”

Section: Discussionmentioning

confidence: 96%

A Cross-Sectional Study of Various Imaging and Biochemical Biomarkers in Patients with Diabetic Macular Edema in Different Stages of Diabetic Retinopathy

Naveen¹,

Sahu²,

Pathak³

2022

OPTH

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Purpose To compare which imaging and biochemical biomarkers are associated with different stages of diabetic retinopathy (DR) in type 2 diabetes mellitus patients with diabetic macular edema (DME). Patients and Methods It was a cross-sectional, observational study that included 100 patients of DME with different stages of DR. Patients were divided into two groups: Group A – DME with non-proliferative diabetic retinopathy (NPDR) and Group B - DME with proliferative diabetic retinopathy (PDR). Group A was further subdivided into three subgroups: A (1) – DME with mild NPDR, A (2) – DME with moderate NPDR, and A (3) – DME with severe NPDR. The primary outcome measure was the association of imaging and biochemical biomarkers with different stages of DR in patients with DME. Results Out of 100 patients, Group A (1) had 1, Group A (2) 44, Group A (3) 29, and group: B had 29 patients. As Group A (1) had only one patient, we did not include it in the calculation. The overall mean age of the study population was 54.84+9.87 years, with a male preponderance (76%). The HbA1c levels, serum triglyceride level, serum cholesterol level, and microalbuminuria level showed no significant association with different stages of DR (P>0.05). Still, we found high serum urea levels (p=0.027) in Group B patients. The optical coherence tomography (OCT)-based imaging biomarkers – central subfield thickness (CST), cystoid macular edema (CME), subretinal fluid (SRF), and hyperreflective foci (HRF) – showed no significant association with various stages of DR. The presence of diffuse retinal thickness (DRT) (p=0.04) and the epiretinal membrane (ERM) (p=0.04) showed significant association with Group B patients. Conclusion The essential biochemical biomarkers such as serum urea levels and DRT and ERM may be considered an important imaging biomarker for the advanced stage of DR.

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Section: Discussionmentioning

confidence: 96%

A Cross-Sectional Study of Various Imaging and Biochemical Biomarkers in Patients with Diabetic Macular Edema in Different Stages of Diabetic Retinopathy

Naveen¹,

Sahu²,

Pathak³

2022

OPTH

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“…ERM is a pathology caused by brocellular proliferation on the ILM followed by intravitreal injections for DME treatment or secondary to a wide variety of diseases, such as DN and cataract surgery [29,30] . ERM formation causes anteroposterior and tangential forces in the retina, resulting in further damage to the blood retina barrier (BRB), the release of in ammatory factors and the deterioration of DME [31] .…”

Section: Discussionmentioning

confidence: 99%

The effect of long-term hemodialysis on diabetic retinopathy observed by swept-source optical coherence tomography angiography

He,

Liu,

Shi

et al. 2024

Preprint

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Background Diabetes can cause chronic microvascular complications such as diabetic retinopathy (DR) and diabetic nephropathy (DN). DR and DN can lead to or exacerbate diabetic macular edema (DME). Hemodialysis (HD) is the main treatment method for patients with end-stage kidney disease (ESKD) secondary to DN. Purpose The aim of this prospective cohort study was to determine the changes in retinal and choroidal thickness in patients with ESKD before and after HD and the impact of long-term HD on DR. Methods Eighty-five eyes of 44 DR patients with ESKD who underwent HD were examined by swept-source optical coherence tomography angiography (SS-OCTA). Based on OCTA images, the characteristics of DR and the prevalence of DME in these patients were analyzed. Changes in central retinal thickness (CRT), central retinal volume (CRV), subfoveal choroidal thickness (SFCT) and subfoveal choroidal volume (SFCV) within 30 minutes before and after HD were compared. CRT, CRV, SFCT and SFCV were compared before HD and before the next HD. Results There was no significant difference in the average CRT (251.69 ± 39.21 µm vs. 251.46 ± 39.38 µm, P = 0.286) or CRV (0.15 ± 0.62 µm vs. 0.15 ± 0.63 µm, P = 0.324) between before and after HD. After HD, SFCT (243.11 ± 77.15 µm vs. 219.20 ± 72.84 µm, P < 0.001) and SFCV (0.15 ± 0.10 µm vs. 0.13 ± 0.90 µm, P < 0.001). significantly decreased. There was no statistically significant difference in CRT (251.69 ± 39.21 µm vs. 251.11 ± 38.47 µm, P = 0.206), CRV (0.15 ± 0.62 µm vs. 0.15 ± 0.61 µm, P = 0.154), SFCT (243.11 ± 77.15 µm vs. 245.41 ± 76.23 µm, P = 0.108), or SFCV (0.15 ± 0.10 µm vs. 0.16 ± 0.10 µm, P = 0.174) before HD and before the next HD. On en face OCTA images, eighty-five eyes (100%) had retinal nonperfusion areas, focal avascular zone (FAZ) enlargement, and abnormal retinal microvasculature. Based on cross-sectional OCTA images, retinal neovascularization (RNV) was confirmed in 42 eyes (49.41%), and intraretinal microvascular abnormalities (IRMAs) were detected in 85 eyes (100%). Seventeen eyes (20%) still had DME, and all had cystoid macular edema (CME). Among eyes with DME, the epiretinal membrane (ERM) was present in 7 eyes (8.24%). Conclusions For DR patients with ESKD who have undergone long-term HD, the choroidal thickness still changes significantly before and after HD, which may be related to short-term effects such as reduced blood volume and plasma osmotic pressure caused by HD. Although HD can improve DME, the DR of patients with ESKD should still be given attention.

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“…Several different imaging modalities are currently used in the diagnosis and the evaluation of severity and progression of ERM, such as colour fundus photography (CFP), optical coherence tomography (OCT) and the recently introduced MultiColor imaging (MC) technique. The ERM appearance on CFP resembles findings obtained by clinical examination, and CFP has been the gold standard in many epidemiological eye disease studies (Ng et al 2011;Knyazer et al 2016;Cheung et al 2017). However, ERM evaluation using CFP presents limitations, mainly due to low contrast and resolution.…”

Section: Introductionmentioning

confidence: 85%

Comparison of MultiColor fundus imaging and colour fundus photography in the evaluation of epiretinal membrane

Song

Moon

Jang

et al. 2018

Acta Ophthalmologica

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Purpose To compare MultiColor fundus imaging (MC) and colour fundus photography (CFP) for the evaluation of epiretinal membrane (ERM). Methods In this retrospective study, 192 eyes (181 patients) that underwent vitrectomy for ERM were imaged using Spectralis optical coherence tomography (for MC) and AFC‐210 digital camera (for CFP) 1 week before vitrectomy. Two investigators independently determined the rate of delineability and ERM area for each modality. Results The intergrader agreement rates for delineability were very high for both image modalities. The rate of delineability of ERM (%) was higher for MC than for CFP, for both investigators [70.8% versus 52.6% and 73.4% versus 53.6% (both p –)]. Epiretinal membrane (ERM) area measurement showed high agreement between investigators for MC (p = 0.466) but differed significantly between the investigators for CFP (p –). The ERM area determined on MC was significantly wider than that on CFP for both investigators (p – for investigator 1 and p – for investigator 2). Conclusion The ERM area is more clearly detectable and widely demarcated in MC than in CFP images. MultiColor imaging (MC) may be more sensitive and accurate for early detection of ERM and ERM area measurement.

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Epiretinal membrane in diabetes mellitus patients screened by nonmydriatic fundus camera

Cited by 12 publications

References 38 publications

A Cross-Sectional Study of Various Imaging and Biochemical Biomarkers in Patients with Diabetic Macular Edema in Different Stages of Diabetic Retinopathy

A Cross-Sectional Study of Various Imaging and Biochemical Biomarkers in Patients with Diabetic Macular Edema in Different Stages of Diabetic Retinopathy

The effect of long-term hemodialysis on diabetic retinopathy observed by swept-source optical coherence tomography angiography

Comparison of MultiColor fundus imaging and colour fundus photography in the evaluation of epiretinal membrane

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