Epiphysial Dysgenesis Associated With Hypothyroidism

Further Studies on Endemic Cretinism in Central Africa

“…3) The X-ray findings, whieh support the hypothesis of Dumont, Ermans and Bastenie (1963a) that this type of eretinism eould result from thyroid damage du ring foetal life or early infaney; the X-rays show that, in six ou t of eight eretins studied, hypothyroidism appeared around birth or during the first months of life (Wilkins 1941, Caffey 1967.…”

Treatment of posterior ankle pain by excision of a bipartite talar fragment

“…Endocrine factors must also be excluded when bony anomalies present since hypothyroid epiphyseal dysgenesis is characterised by multiple foci of bipartition in the hands and feet. 17 Our patients did not have an endocrinopathy, neither there a family history of tarsal anomalies. Commonly, divisions of bones are acquired secondary to trauma though some may have a hereditary basis.…”

Post-Cranial Skeletons of Hypothyroid Cretins Show a Similar Anatomical Mosaic as Homo floresiensis

“…A trapezoid like this, that is small relative to the capitate, is not found in Ardipithecus ramidus [19] , or any ape or any normal human, but trapezoids are generally not described for early hominins [20] . Small trapezoids do, however, sometimes occur in adult human cretins because there may be delayed ossification of the ventral portion of the bone in younger cretins, or failure of fusion of the two parts of the bone with loss of the smaller ventral portion after death [7] [21] . A young adult cretin (Basle, specimen 84, male) shows exactly such an incomplete trapezoid lacking a ventral tip adjacent to a normal capitate.…”