Epinephrine versus epinephrine plus fibrin glue injection in peptic ulcer bleeding: A prospective randomized trial

Pescatore, Pierre; Jornod, Philippe; Borovicka, Jan; Pantoflickova, D.; Suter, Walter; Meyenberger, Christa; Blum, A. L.; Dorta, Gian

doi:10.1067/mge.2002.121875

Cited by 57 publications

(36 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Comorbidities in this study were better stratified. More recently, Lin et al 21 have made a direct comparison between adrenaline and fibrin although with smaller numbers (n = 26 each group). They showed rebleeding was higher in the adrenaline group (14 compared with 4) but transfusion requirements, surgery, and mortality were similar.…”

Section: Fibrin Glue and Thrombinmentioning

confidence: 99%

Acute endoscopic intervention in non-variceal upper gastrointestinal bleeding

Arasaradnam¹,

Donnelly²

2005

Postgraduate Medical Journal

View full text Add to dashboard Cite

Upper gastrointestinal bleeding is one of the commonest emergencies encountered by general physicians. Once haemodynamic stability has been achieved, therapeutic endoscopy is vital in control and arrest of bleeding. Various methods are available and the evidence is reviewed as to the most optimal approach. Clinical parameters including timing of endoscopy, risk stratification, and predictors of failure will also be discussed together with a summary of recommendations based on current available evidence.

show abstract

Section: Fibrin Glue and Thrombinmentioning

confidence: 99%

Acute endoscopic intervention in non-variceal upper gastrointestinal bleeding

Arasaradnam¹,

Donnelly²

2005

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…However, Pescatore et al . [15] found that injection of epinephrine alone and epinephrine plus fibrin glue does not have comparable recurrent bleeding rates, indicating that adding fibrin glue to epinephrine is not superior to epinephrine injection alone in the treatment of high-risk bleeding peptic ulcers. Due to increasing number of reports describing differential and conflicting results, more extensive studies in larger groups of patients should be undertaken to analyze the putative role of adding a second agent to epinephrine for injection treatment of patients with high-risk bleeding ulcers.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic treatment for high-risk bleeding peptic ulcers: A randomized, controlled trial of epinephrine alone with epinephrine plus fresh frozen plasma

et al. 2016

View full text Add to dashboard Cite

Background:Acute upper gastrointestinal bleeding is a common and potentially life-threatening emergency with substantial mortality. Fresh frozen plasma (FFP), a good source of coagulation factors, might be an ideal injection agent based on its physiologic properties. Therefore, we evaluated the role of FFP as a hemostatic agent in patients with high-risk bleeding peptic ulcers.Materials and Methods:From August 2015 to April 2016, 108 consecutive patients with high-risk bleeding ulcers were admitted to our university hospital. They were randomly assigned to undergo injection of epinephrine alone (A) or epinephrine plus FFP (B). The primary outcomes assessed were the initial hemostasis, recurrent bleeding, hospital stay, blood transfusion, surgery rate, and 14-day mortality.Results:Initial hemostasis was achieved in 47 of 50 patients (94%) in the Group A and 49 of 50 patients (98%) in the Group B (P = 0.61). There were no significant differences in the rate of recurrent bleeding between Group A (14%) and Group B (8%) (P = 0.52). We found no significant differences between Group A and Group B with respect to the surgery rate, bleeding death, procedure-related death, and duration of hospitalization (P > 0.05).Conclusion:It is concluded the injection of epinephrine alone was equally effective as injection of epinephrine plus FFP to endoscopic hemostasis. Epinephrine alone and epinephrine plus FFP were not different in recurrent bleeding, rate of surgery, blood transfusion, or mortality.

show abstract

“…38 Other studies did not confirm any advantage in adding the fibrin glue to epinephrine injection alone. 39 The precise role for fibrin sealant remains to be defined. Moreover, because the substance is relatively expensive and its use can be associated with the potential transmission of infectious diseases today, the use of fibrin glue is discouraged as a primary treatment modality.…”

Section: Fibrin Gluementioning

confidence: 99%