Epinephrine promotes hemostasis in rats with cyclophosphamide-induced hemorrhagic cystitis

Chow, Yung-Chiong; Yang, Stone; Huang, Chengwei; Tzen, Chin‐Yuan; Huang, Pei-Lin; Su, Yu-Hsien; Wang, Paulus S.

doi:10.1016/j.urology.2005.10.003

Cited by 22 publications

(28 citation statements)

References 22 publications

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“…All panels, hematoxylin-eosin stain. Original magnification ×40 in all panels for preventing HC, a great percentage of patients under treatment with CYP will develop HC (Chow et al 2006;Monach et al 2010). Furthermore, the treatment with Mesna, especially in children and young adults, might be associated with remarkable side effects, such as hypersensitivity-like cutaneous and systemic reactions (Khaw et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Effects of the hydroalcoholic extract of Phyllanthus niruri and its isolated compounds on cyclophosphamide-induced hemorrhagic cystitis in mouse

Boeira

Leite

Santos

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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The effects of Phyllanthus niruri hydroalcoholic extract and the isolated compounds quercetin, rutin, and gallic acid were examined in the mouse model of cyclophosphamide (CYP)-induced hemorrhagic cystitis (HC). HC was induced by a single CYP injection (300 mg/kg, IP), and the animals were evaluated 4 and 6 h after. Some animals were orally treated with the reference compound 2-mercaptoethane sodium sulfonate (Mesna) 80 mg/kg (30 min before CYP) and 160 mg/kg (2 h after CYP). Other groups were treated with P. niruri extract (30 and 50 mg/kg), or quercetin, rutin, and gallic acid (10 and 20 mg/kg), given orally, at the same intervals described for Mesna. P. niruri extract and its active components produced a significant attenuation of the nociception, edema, and hemorrhage evoked by CYP, which was similar to that seen for Mesna. Gallic acid and rutin displayed greater anti-inflammatory effects, whereas quercetin presented superior antinociceptive activities. Noteworthy is that P. niruri extract and compounds significantly reduced CYP-induced liver lipid peroxidation. Our results shed new light on the beneficial effects of P. niruri extract and its active compounds in attenuating the collateral effects elicited by the chemotherapeutic agent CYP.

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Section: Discussionmentioning

confidence: 99%

Effects of the hydroalcoholic extract of Phyllanthus niruri and its isolated compounds on cyclophosphamide-induced hemorrhagic cystitis in mouse

Boeira

Leite

Santos

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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“…for acute cystitis as previously described (4,18), and were used for the experiment three days later. Sham rats received a volume-matched injection of saline (5 mL/kg, i.p.).…”

Section: Induction Of Chemical Cystitis and Administration Of Plant Ementioning

confidence: 99%

Beneficial Effects of Gosha-jinki-gan and Green Tea Extract in Rats With Chemical Cystitis

Nasrin¹,

Osano²,

Ito³

et al. 2013

J Pharmacol Sci

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Abstract. The aim of this study was to characterize pharmacological effects of gosha-jinki-gan (GJG) and green tea extract (GTE), on urodynamic parameters, bladder receptors, and urinary cytokines in rats with cyclophosphamide (CYP)-induced cystitis. Urodynamic parameters in CYPtreated rats were measured using the cystometric method. Muscarinic and purinergic receptors in rat tissues were measured by radioreceptor assays. Urinary cytokine levels were measured with ELISA kits. GJG and GTE were orally administered to rats once a day for 7 days. The GJG treatment significantly ameliorated changes in urodynamic parameters in CYP-treated rats. Similar treatment with GTE slightly attenuated changes in urodynamic parameters. The maximal number of binding sites for [ H]NMS and [3 H]ab-MeATP in the bladder was significantly lower in CYPtreated rats than in sham rats. Such a reduction in receptor density was significantly attenuated by the GJG treatment. GTE treatment also significantly attenuated the down-regulation of muscarinic receptors, but not P2X receptors in bladders of rats with CYP-induced cystitis. The elevation in urinary cytokine levels in CYP-treated rats was effectively attenuated by GJG treatment. The elevation in cytokine levels in CYP-treated rats was alleviated by GTE treatment. In conclusion, GJG may be a pharmacologically useful plant extract for cystitis.

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“…Many prospective agents to reduce hemorrhagic cystitis have been reported in numerous literatures (Katz et al 1995;Elias et al 1989;Chow et al 2006). However, there have been clinical discrepancies in the ameliorating effect by the agents in patients who receive CYP-based chemotherapy (Elias et al 1989;Takamoto et al 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Uroplakin II (UPII) expression among four UP subunits (UPIa, UPIb, UPII, and UPIII) in urinary bladder strongly correlates with the histopathological parameters for hemorrhage cystitis in CYP-induced animal models of cystitis (Kyung et al 2011). Epinephrine (EPI) is a promising drug to decrease the incidence and severity of CYP-induced rat cystitis (Chow et al 2006). Moreover, EPI has a greater preservative effect than that of 2-mercaptoethane sodium sulfonate, a promising clinical prophylactic agent in CYP-induced cystitis (Chow et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Intravesical epinephrine preserves uroplakin II expression in urinary bladder from cyclophosphamide-induced rat cystitis

Kyung

Park

Lee

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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We investigated the attenuated effect of intravesical epinephrine (EPI) on uroplakin II (UPII) expression in cyclophosphamide (CYP)-induced rat cystitis. Sixty-eight Sprague-Dawley female rats were divided into one negative control group (GI) and five intraperitoneally CYP (150 mg CYP/kg)-injected groups (GII-VI) consisting of a positive control group (GII), three groups (GIII-V) with retaining intravesically instillated ameliorating agents for 90 min by urethral ligation until sacrifice, and one group (GVI) with freely voiding after intravesical EPI instillation. The retention groups were further classified into null-treated- (GIII), EPI- (GIV), and vehicle group (GV). All rats were euthanized 24 h after CYP injection. The UPII and α1-adrenergic receptors (AR) levels were measured with real-time polymerase chain reaction (RT-PCR) method and the morphological changes were also evaluated. CYP induced severe cystitis and decreased vesical UPII mRNA level. The EPI-treated groups had showed attenuation effects against submucosal edema and hemorrhage, and preserved UPII expression. Concurrently, intravesical EPI resulted in a significant preservation of both subtypes of α1A- and α1B AR expressions, which was well correlated with the hemostatic pattern in the samples. The obstructed and null-treated group (GIII) revealed severe cystitis and maximally decreased UPII levels, and the diluting effect of vehicle (GV) on CYP toxicity was insignificant on UPII preservation. The UPII level of RT-PCR was well correlated with the UPII immunohistological expression and their morphological changes. Intravesical instillation of EPI preserves UPII expression and attenuates the toxic responses in the bladder in CYP-induced rat cystitis.

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Epinephrine promotes hemostasis in rats with cyclophosphamide-induced hemorrhagic cystitis

Cited by 22 publications

References 22 publications

Effects of the hydroalcoholic extract of Phyllanthus niruri and its isolated compounds on cyclophosphamide-induced hemorrhagic cystitis in mouse

Effects of the hydroalcoholic extract of Phyllanthus niruri and its isolated compounds on cyclophosphamide-induced hemorrhagic cystitis in mouse

Beneficial Effects of Gosha-jinki-gan and Green Tea Extract in Rats With Chemical Cystitis

Intravesical epinephrine preserves uroplakin II expression in urinary bladder from cyclophosphamide-induced rat cystitis

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