Epinephrine potentiates antipsychotic, but not cataleptogenic effect of haloperidol in rats

Гмиро, В. Е.; Serdyuk, S. E.

doi:10.1007/s10517-007-0197-5

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…In our experiments, it was shown that stimulation of vagal afferents of the gastric mucosa by adrenomimetics (adrenaline, phenylephrine) when administered systemically at threshold doses potentiates the therapeutic effect of small doses of analgesics, antidepressants, neuroleptics, antiepileptics, and other CNS drugs to the level of therapeutic effects of therapeutic doses of the CNS drugs, but does not enhance their side effects [1,4].…”

Section: Introductionmentioning

confidence: 72%

Stimulation of Vagus By Phenylephrine Increases the Efficiency and Safety of Antidepressants and Anti-Epileptics

Serdyuk¹,

Гмиро²

2019

EJGM

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Background: Earlier, we discovered the possibility of potentiation of the therapeutic effects of small (threshold) doses of CNS agents by phenylephrine and adrenaline, while eliminating their side effects. However, the question of the possibility of potentiation by phenylephrine and other CNS potentiators of high therapeutic doses of CNS agents remained unstudied. This study is devoted to the research of this problem. Objective: The aim of the study was to investigate the effect of the threshold dose of phenylephrine on the antidepressant effect of amitriptyline and the anticonvulsant effect of diazepam, as well as their side sedation in high doses. Method: The experiments were carried out on the animated models of depression (Porsolt test) and epilepsy (clonic pentylenetetrazole (PTZ)-induced seizures), resistant to antidepressants and antiepileptics even at high therapeutic doses. Side sedative effect of substances was evaluated in the "open field" test. Results: We established that the stimulation of gastric vagal afferents with phenylephrine, when administered orally at threshold doses, potentiates the anticonvulsant effect of diazepam and the antidepressant effect of amitriptyline in high therapeutic doses to the maximum level that is impossible in their application by themselves, and at the same time eliminates their side sedation. Conclusion: A synergistic effect of phenylephrine and CNS drugs on the peripheral and central links of the vagal stress-protective reflex is discussed. It is assumed that the potentiation of therapeutic effect by phenylephrine and the elimination of side effects of the CNS agents occurs as a result of strengthening the vagal stress-protective reflex, eliminating the drug stress.

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Section: Introductionmentioning

confidence: 72%

Stimulation of Vagus By Phenylephrine Increases the Efficiency and Safety of Antidepressants and Anti-Epileptics

Serdyuk¹,

Гмиро²

2019

EJGM

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Phenylephrine Potentiates the Anticonvulsant Effect and Neutralizes the Sedative Effect of Diazepam in Rats upon Combined Intragastric Administration

Serdyuk

Гмиро

2014

Bull Exp Biol Med

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High doses of phenylephrine and diazepam (1 and 10 mg/kg, respectively) suppressed the development of generalized tonic-clonic pentylenetetrazole-induced convulsions in 86-100% rats, but did not prevent local clonic pentylenetetrazole-induced convulsions. Diazepam in the specified dose produced strong sedation, while phenylephrine had no sedative effect in the open-field test. Combined intragastric administration of phenylephrine in a medium and individually ineffective dose (0.3 mg/kg) and diazepam in a high dose (10 mg/kg) potentiated the anticonvulsant effect of diazepam: it prevented not only tonic-clonic, but also clonic pentylenetetrazole-induced convulsions in 100% rats and 2.6-fold increased anticonvulsant activity of diazepam. The specified combination of diazepam and phenylephrine had no sedative effect. The mechanism of potentiation of the anticonvulsive effect and elimination of the sedative side effect is based on stimulation of gastric mucosa afferents by phenylephrine.

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Synthesis and Pharmacological Properties of N-Decyltropine (IEM-1556) as Compared to Selective Nicotinic Receptor Antagonist Tert-Butyldecylammonium (IEM-1678)

Гмиро

Serdyuk

2019

Pharm Chem J

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Epinephrine potentiates antipsychotic, but not cataleptogenic effect of haloperidol in rats

Cited by 4 publications

References 13 publications

Stimulation of Vagus By Phenylephrine Increases the Efficiency and Safety of Antidepressants and Anti-Epileptics

Stimulation of Vagus By Phenylephrine Increases the Efficiency and Safety of Antidepressants and Anti-Epileptics

Phenylephrine Potentiates the Anticonvulsant Effect and Neutralizes the Sedative Effect of Diazepam in Rats upon Combined Intragastric Administration

Synthesis and Pharmacological Properties of N-Decyltropine (IEM-1556) as Compared to Selective Nicotinic Receptor Antagonist Tert-Butyldecylammonium (IEM-1678)

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