Epinephrine Hypertension

Prohaska, John Van; Harms, H; Dragstedt, Lester R.

doi:10.1097/00000658-193711000-00004

Cited by 7 publications

(2 citation statements)

References 2 publications

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“…Ligation of pancreatic ducts, though not without difficulties, has been used in the study of hepatic dysfunction. The first to produce fatty livers in dogs by this procedure were Aubertin et al (52). A reinvestigation of this subject was therefore undertaken by Montgomery and associates.…”

Section: Relation Of External Secretion Of the Pancreas To Fat Metmentioning

confidence: 99%

Antifatty‐Liver Factor of the Pancreas—Present Status

Chaikoff

Entenman

1948

Advances in Enzymology - And Related Areas of Molecular Biology

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Section: Relation Of External Secretion Of the Pancreas To Fat Metmentioning

confidence: 99%

Antifatty‐Liver Factor of the Pancreas—Present Status

Chaikoff

Entenman

1948

Advances in Enzymology - And Related Areas of Molecular Biology

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“…It is of course a well-known observation that after a large single dose, the pressor effect is followed by a temporary fall. The view that excessive sympathetic activity is a cause of shock has many opponents, who quote the evidence of Prohaska, Harms & Dragstedt [1937] that continuous adrenaline infusion of amounts up to 0-003 mg./kg./min. into dogs did not cause death from shock.…”

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confidence: 99%

An action of adrenaline on transmission in sympathetic ganglia, which may play a part in shock

Bülbring¹,

Burn²

1942

The Journal of Physiology

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We have had two reasons for approaching this problem. One of us [Burn, 1932] showed that when the hindleg of a dog was perfused with defibrinated blood through a cannula tied in the abdominal aorta 34 cm. above the bifurcation, the vasoconstriction produced by stimulating the lumbar sympathetic chain was very small. When adrenaline was added to the perfusing blood, however, the effect of the same stimulation was greater, and this augmentation outlasted the effect of the added adrenaline on the vascular tone. The observations were taken to mean that sympathetic stimulation was effected by the liberation of adrenaline from the post-ganglionic endings, and that in the preparation used the necessary store of this adrenaline was depleted, until it was restored by addition of adrenaline to the blood. Thus, the augmentation of the effect of sympathetic stimulation was thought to be due to a change at the post-ganglionic terminations.Recently, Dr P. Glees called our attention to a paper by Stohr [1939] in which large-scale drawings of sympathetic ganglia showed the ganglion cells surrounded by what St6hr described as chromaffine tissue. Dr Glees himself obtained phlotographs showing similar small cells. Reflexion suggested that if chromaffine celLs were present in sympathetic ganglia, they presumably exerted some function. What function could adrenaline have in sympathetic ganglia? The question recalled the observations which have just been described, in which the stimulation was applied to the preganglionic fibres of the sympathetic chain. It was clear that the augmentation of the effect of stimulation produced by adrenaline might have been due to a change in the ganglion whereby transmission was improved.Our second reason for studying this question was that we have recently [Biilbring & Burn, 1941] made observations on the transmission of impulses in the spinal cord, and have observed three effects of adrenaline. We found that adrenaline facilitated the action of small doses of acetylcholine in causing PH. CI. 20

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Vascular Diseases

Scupham¹

1940

Arch Intern Med (Chic)

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Epinephrine Hypertension

Cited by 7 publications

References 2 publications

Antifatty‐Liver Factor of the Pancreas—Present Status

Antifatty‐Liver Factor of the Pancreas—Present Status

An action of adrenaline on transmission in sympathetic ganglia, which may play a part in shock

Vascular Diseases

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