Epinecidin-1, an antimicrobial peptide from fish (Epinephelus coioides) which has an antitumor effect like lytic peptides in human fibrosarcoma cells

Lin, Wei-Ju; Chien, Yi-Lun; Pan, Chia-Yu; Lin, Tai-Lang; Chen, Jyh-Yih; Chiu, Shu-Jun; Hui, Cho-Fat

doi:10.1016/j.peptides.2008.10.007

Cited by 92 publications

(38 citation statements)

References 17 publications

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“…It has secondary structures that closely resemble those of pleurocidin found in the winter flounder (Pleuronectes americanus) [2]. Epinecidin-1 is readily incorporated into cellular membranes of bacteria, fungi, and tumor cells which results in the formation of pores in membranes leading to pathogen and tumor cell death [3,4]. We previously characterized the lytic activities of synthetic epinecidin-1 against several gram-positive and -negative bacteria, and electroporated the plasmid containing the epinecidin-1 complementary (c)DNA sequence under a cytomegalovirus (CMV) promoter into zebrafish muscle to protect fish against Vibrio vulnificus infection [5].…”

Section: Introductionmentioning

confidence: 90%

Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection

Peng

Pan

Chou

et al. 2010

Fish & Shellfish Immunology

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Section: Introductionmentioning

confidence: 90%

Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection

Peng

Pan

Chou

et al. 2010

Fish & Shellfish Immunology

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“…One possibility is the use of antimicrobial peptides (AMPs), such as the newly identified epinecidin-1. Ep-inecidin-1 has been reported to have antisepsis, antitumor, antivirus, and immunomodulatory activities and may be useful in combating MDR infections (26,27,(31)(32)(33). This study aimed to evaluate the potential clinical use of epinecidin-1, whose effects were compared with those of conventional antibiotics, which are generally the last line of defense against infections caused by MDR P. aeruginosa.…”

Section: Discussionmentioning

confidence: 99%

Epinecidin-1 Has Immunomodulatory Effects, Facilitating Its Therapeutic Use in a Mouse Model of Pseudomonas aeruginosa Sepsis

Pan

Chen

Sheen

et al. 2014

Antimicrob Agents Chemother

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e Antimicrobial peptides (AMPs) are garnering attention as possible alternatives to antibiotics. Here, we describe the antimicrobial properties of epinecidin-1 against a multidrug-resistant clinical isolate of P. aeruginosa (P. aeruginosa R) and a P. aeruginosa strain from ATCC (P. aeruginosa ATCC 19660) in vivo. The MICs of epinecidin-1 against P. aeruginosa R and P. aeruginosa ATCC 19660 were determined and compared with those of imipenem. Epinecidin-1 was found to be highly effective at combating peritonitis infection caused by P. aeruginosa R or P. aeruginosa ATCC 19660 in mouse models, without inducing adverse behavioral effects or liver or kidney toxicity. Taken together, our results indicate that epinecidin-1 enhances the rate of survival of mice infected with the bacterial pathogen P. aeruginosa through both antimicrobial and immunomodulatory effects.

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“…The isolated peptide could inhibit VEGF induced migration and tubulogenesis of human umbilical vein endothelial cells (HUVECs) [81]. As summarized in Table 2, anti-cancer peptides from other marine fish such as pipefish, Red Sea Moses sole, tuna, anchovy and grouper have also been isolated and purified [82,83,84,85,86]. The peptides isolated from marine fish showed anti-cancer activity in human breast cancer (MCF-7), human lung carcinoma (A549), human leukemic lymphoblasts (CCRF-CEM), hepatocellular carcinoma (HA59T/VGH), cervical cancer [87], human liver cancer (HepG2), human fibrosarcoma (HT1080), human myeloid leukemia (U937), human prostate cancer (PC-3), and oral squamous cell carcinoma (OSCC) cells.…”

Section: Marine-derived Anti-cancer Peptidesmentioning

confidence: 99%

Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases

Pangestuti

Kim

2017

Marine Drugs

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Non-communicable diseases (NCD) are the leading cause of death and disability worldwide. The four main leading causes of NCD are cardiovascular diseases, cancers, respiratory diseases and diabetes. Recognizing the devastating impact of NCD, novel prevention and treatment strategies are extensively sought. Marine organisms are considered as an important source of bioactive peptides that can exert biological functions to prevent and treatment of NCD. Recent pharmacological investigations reported cardio protective, anticancer, antioxidative, anti-diabetic, and anti-obesity effects of marine-derived bioactive peptides. Moreover, there is available evidence supporting the utilization of marine organisms and its bioactive peptides to alleviate NCD. Marine-derived bioactive peptides are alternative sources for synthetic ingredients that can contribute to a consumer’s well-being, as a part of nutraceuticals and functional foods. This contribution focus on the bioactive peptides derived from marine organisms and elaborates its possible prevention and therapeutic roles in NCD.

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Epinecidin-1, an antimicrobial peptide from fish (Epinephelus coioides) which has an antitumor effect like lytic peptides in human fibrosarcoma cells

Cited by 92 publications

References 17 publications

Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection

Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection

Epinecidin-1 Has Immunomodulatory Effects, Facilitating Its Therapeutic Use in a Mouse Model of Pseudomonas aeruginosa Sepsis

Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases

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