Epimeric Excolides from the Stems of <i>Excoecaria agallocha</i> and Structural Revision of Rhizophorin A

Annam, Suresh; Ankireddy, Madhu; Sura, Madhu Babu; Ponnapalli, Mangala Gowri; Sarma, Akella V. S.; S, Jeelani Basha

doi:10.1021/acs.orglett.5b01257

Cited by 21 publications

(10 citation statements)

References 15 publications

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“…1012 CD analysis and an X-ray study has led to the revision of the structure of rhizophorin A (Rhizophora mucronata) 1013 to that shown for excolide A 1377. 1008 The structure of excolide B 1380 was also secured by X-ray analysis. human T-cell leukemia xenogras, via a mechanism involving ROS-mediated apoptosis and cell cycle arrest.…”

Section: Mangrovesmentioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Mangrovesmentioning

confidence: 99%

Marine natural products

et al. 2017

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“…More than 72 cytotoxic diterpenoids have been identified from E . agallocha , structurally belonging to labdane (Konishi et al, 1999 , 2003 ; Anjaneyulu and Rao, 2000 ; Annam et al, 2015 ), isopimarane/ ent -isopimarane (Anjaneyulu et al, 2003 ; Wang and Guo, 2004 ; Kang et al, 2005 ; Wang et al, 2005 ; Gowri Ponnapalli et al, 2013 ), atisane/ ent -atisane (Konishi et al, 2000 ; Wang et al, 2009 ), ent -kaurane (Anjaneyulu et al, 2002 ; Li et al, 2010 ), and beyerane-type (Anjaneyulu et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Polyketides From the Endophytic Fungus Cladosporium sp. Isolated From the Mangrove Plant Excoecaria agallocha

et al. 2018

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Five new polyketides (2–6) and ten known compounds (1 and 7–15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2–6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC50 value of 10.0 μM. Compounds 4 and 8–10 showed radical scavenging activity against DPPH with the IC50 values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8–10 in this paper.

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“…[822232425262728293031323334353637383940414243444546474849505152535455] The details of their names are given in Table 5. The chemical structures of some isolated compounds are given in Figure 2.…”

Section: Introductionmentioning

confidence: 99%

“…About 41 labdane-type diterpenes 1–41 were isolated from E. agallocha . [822232425262728293031323334] Two new bis seco-labdane diterpenes 17 and 18 were isolated from resinous woods. [26] Several seco-labdane diterpenes were also isolated from the same plant.…”

Section: Introductionmentioning

confidence: 99%

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A complete profile on blind-your-eye mangrove Excoecaria agallocha L. (Euphorbiaceae): Ethnobotany, phytochemistry, and pharmacological aspects

Mondal¹,

Ghosh²,

Ramakrishna³

2016

Phcog Rev

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Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances. This article provides a comprehensive review of the complete profile of an important mangrove plant Excoecaria agallocha L. (Euphorbiaceae) and elaborately describing the ethnobotany, phytochemistry, and pharmacological properties. It is used traditionally in the treatment of various diseases such as epilepsy, ulcers, leprosy, rheumatism, and paralysis. The latex obtained from the bark is poisonous in nature and may cause temporary blindness, thus it is also known as the blind-your-eye mangrove plant. Many phytoconstituents were isolated from the plant, which were mainly diterpenoids, triterpenoids, flavonoids, sterols, and few other compounds. The plant also showed many pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory, analgesic, antiulcer, anticancer, antireverse transcriptase, antihistamine-release, antifilarial, DNA damage protective, antidiabetic, and antitumor protecting activities. Hence, this review could help guide researchers anticipating to undertake further investigations in these directions.

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Epimeric Excolides from the Stems of Excoecaria agallocha and Structural Revision of Rhizophorin A

Cited by 21 publications

References 15 publications

Marine natural products

Marine natural products

Polyketides From the Endophytic Fungus Cladosporium sp. Isolated From the Mangrove Plant Excoecaria agallocha

A complete profile on blind-your-eye mangrove Excoecaria agallocha L. (Euphorbiaceae): Ethnobotany, phytochemistry, and pharmacological aspects

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