Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes

Carter, William G.; Ryan, Maureen C.; Gahr, Pamaia J.

doi:10.1016/0092-8674(91)90092-d

Cited by 736 publications

(545 citation statements)

References 52 publications

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“…20 The laminin-5 isoform has an important role in epithelial cell adhesion to the basement membrane. 21 Increased expression has been found not only at the invasion front of colorectal cancers but also in premalignant lesions, such as ulcerative colitis mucosa. 14,22 In our data, increased cyclin A and laminin-5 immunoreactivity indicate adenoma cells with increased proliferative and malignancy potential, respectively.…”

Section: Discussionmentioning

confidence: 99%

Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma

et al. 2011

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Individual colorectal adenomas have different propensities to progress to invasive disease. In this study, we explored whether these differences could be explained by gene copy number alterations. We evaluated 18 adenomas of patients without synchronous or subsequent carcinoma (6.5 years follow-up), 23 adenomas of carcinoma patients, and 6 related carcinomas. All samples were measured for their DNA ploidy status. Centromere probes for chromosomes 17 and 18, as well as gene-specific probes for SMAD7, EGFR, NCOA3, TP53, MYC, and RAB20 were assessed by multicolor fluorescence in situ hybridization. An increased genomic instability index of CEP17, SMAD7, and EGFR, as well as TP53 deletions and MYC amplifications defined adenomas of patients with synchronous carcinoma (Po0.05). Diploid NCOA3 signal counts were associated with longer adenoma recurrence-free surveillance (P ¼ 0.042). In addition, NCOA3, MYC, EGFR, and RAB20 amplifications, as well as TP53 deletions correlated with increased DNA stem line values and/or aneuploidy in adenomas (Po0.05). Furthermore, aberrations of NCOA3, MYC, and RAB20 were associated with histopathologically defined high-risk adenomas (Po0.05). RAB20 amplifications were also correlated with high-grade dysplastic adenomas (P ¼ 0.002). We conclude that genomic instability in colorectal adenomas is reflected by EGFR, MYC, NCOA3, and RAB20 amplifications that do correlate with histomorphological features and are indicative for adenoma recurrence and the presence of synchronous carcinomas.

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Section: Discussionmentioning

confidence: 99%

Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma

et al. 2011

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“…1,23,24 Recently, it was reported that laminin 5 promotes the migration and invasion of tumor cells in various types of tumors. [5][6][7][8][9][10] In patients with pancreatic carcinoma, Tani et al reported that pancreatic carcinomas synthesize and deposit laminin 5 in the basement membrane, and invading cells supposedly migrate on the newly deposited basement membrane.…”

Section: Discussionmentioning

confidence: 99%

Cytoplasmic expression of laminin γ2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma

Takahashi

Hasebe

Oda

et al. 2002

Cancer

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“…Laminin-332 (previously known as laminin-5), which comprises a3, b3 and g2 chains, is a major component of epithelial BM, acts as an adhesion substrate for the epithelial cells and regulates epithelial cell migration during epithelial regeneration and repair processes in normal tissues (Carter et al, 1991;Rousselle et al, 1991;Ryan et al, 1996). Laminin-332 interacts with two major epithelial integrin a3b1 and a6b4, and promotes the formation of two separate types of attachment structure, focal adhesion and stable anchoring contacts (Carter et al, 1990).…”

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confidence: 99%

Laminin-332 promotes the invasion of oesophageal squamous cell carcinoma via PI3K activation

et al. 2008

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Laminin-332 is major component of epithelial basement membrane, and has an important role in cell migration and tumour invasion. Recently, the phosphatidylinositol 3-kinase (PI3K) activation induced by laminin-332 during carcinogenesis or tumour invasion has been highlighted in skin squamous cell carcinoma. The expression of laminin-332 in 126 resected oesophageal squamous cell carcinoma (ESCC) specimens was immunohistochemically examined to determine its associations with the clinicopathological characteristics, and the effect of laminin-332 on the invasiveness and the PI3K activation was assessed by in vitro experiments using ESCC cell lines (ESCCs). Sections with immunostaining signals in 430% cancer cells, which were observed in 55 of 126 cases, were judged to be positive for laminin-332. The positivity was significantly correlated with pTNM stage and poor prognosis. Inactivation of the PI3K pathway by laminin-332 blocking antibody suppressed the invasiveness of TE8 cell line, which secreted laminin-332 at high level and had high PI3K activity. The addition of the purified laminin-332 activated the PI3K pathway and increased the invasiveness of TE11 cell line, which secreted laminin-332 at lower level and had low PI3K activity. The deactivation of PI3K pathway using the PI3K inhibitor decreased the invasiveness of ESCCs and the secretion of laminin-332 in vitro. The expression of laminin-332 was one of the prognostic factors of ESCC. Laminin-332 could provide the autocrine positive-feedback loop through PI3K activation, contributing the invasive ability. Therefore, the inhibitor of PI3K pathway might be useful as the anticancer therapies for ESCC.

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Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes

Cited by 736 publications

References 52 publications

Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma

Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma

Cytoplasmic expression of laminin γ2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma

Laminin-332 promotes the invasion of oesophageal squamous cell carcinoma via PI3K activation

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