Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data

Gajdoš, Martin; Říha, Pavel; Kojan, Martin; Doležalová, Irena; Mutsaerts, Henk J M M; Petr, Jan; Rektor, Ivan

doi:10.1038/s41598-021-89774-4

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…ASL is an MRI perfusion technique that enables the quantification of cerebral blood flow. Recent studies demonstrated a high efficacy of ASL 19 and similar results of PET and ASL in localizing EZ in MR negative epilepsy 20 . The important advantage of ASL over FDG-PET is its independence from the application of a radioactive tracer, rapid data acquisition within the spectrum of clinical MR recorded in epilepsy patients, and lower costs 35 .…”

Section: Discussionmentioning

confidence: 82%

Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy

Říha

Doležalová

Mareček

et al. 2022

Sci Rep

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The objective was to determine the optimal combination of multimodal imaging methods (IMs) for localizing the epileptogenic zone (EZ) in patients with MR-negative drug-resistant epilepsy. Data from 25 patients with MR-negative focal epilepsy (age 30 ± 10 years, 16M/9F) who underwent surgical resection of the EZ and from 110 healthy controls (age 31 ± 9 years; 56M/54F) were used to evaluate IMs based on 3T MRI, FDG-PET, HD-EEG, and SPECT. Patients with successful outcomes and/or positive histological findings were evaluated. From 38 IMs calculated per patient, 13 methods were selected by evaluating the mutual similarity of the methods and the accuracy of the EZ localization. The best results in postsurgical patients for EZ localization were found for ictal/ interictal SPECT (SISCOM), FDG-PET, arterial spin labeling (ASL), functional regional homogeneity (ReHo), gray matter volume (GMV), cortical thickness, HD electrical source imaging (ESI-HD), amplitude of low-frequency fluctuation (ALFF), diffusion tensor imaging, and kurtosis imaging. Combining IMs provides the method with the most accurate EZ identification in MR-negative epilepsy. The PET, SISCOM, and selected MRI-post-processing techniques are useful for EZ localization for surgical tailoring.

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Section: Discussionmentioning

confidence: 82%

Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy

Říha

Doležalová

Mareček

et al. 2022

Sci Rep

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“…Виявлення можливих структурних змін у головному мозку шляхом застосування методів нейровізуалізації є обов'язковим діагностичним методом під час обстеження дитини з ЕЕ або епілептиформними та розвитковими енцефалопатіями (ЕРЕ), який дозволяє виявити потенційно епілептогенні вогнища та, у багатьох випадках, верифікувати етіологію захворювання. Однак, у 20-50% дітей із рефрактерними до терапії нападами під час проведення МРТ головного мозку, навіть із використанням оптимального протоколу, структурні зміни в мозку не ідентифікуються, що ускладнює подальший діагностичний пошук та може вимагати проведення додаткових методів нейровізуалізації [5,12,26,27].…”

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Neuroimaging features of the nervous system in young children with epileptic encephalopathies according to MR-tractography

Kyrylova,

Miroshnikov,

Yuzva

et al. 2024

MPU

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The aim is to analyze neuroimaging changes in the nervous system of children of an early and preschool age with epileptic encephalopathies (EE) according to MR-tractography to improve the diagnosis of these conditions. Materials and methods. 157 children aged 0 to 6 years with EE, epileptiform and developmental encephalopathies (DEE) were examined. The study included MR-tractography using a 3 Tesla MR scanner. Fractional anisotropy (FA) and average diffusion coefficient (ADC) were determined in Broca's and Wernicke's areas, left arcuate tract, both uncinate tracts, corpus callosum and thalamus. The examined children were divided into 3 groups: I - 75 children with EE, with the onset of seizures before 1 year of age; II - 44 children with EE, with the onset of seizures at the age of 1-3 years; III - 38 children with DEE. Differences between groups were assessed using the Kruskal-Wallis test and Pearson's Chi-square (χ²) test. Results. In children with EE from groups I and II, there was a significant decrease in FA and an increase in ADC in the areas of both language centers and the right uncinate tract in comparison with children of group III (p<0.05). In the group I with EE, there was a significant decrease in FA in the left uncinate tract, knee and trunk of the MT in comparison with the groups II and III of children (p<0.05). It was found that more than 60% of children from group I had destruction of the fibers of the arcuate tract and in the area of one of the speech centers, and 70% had hypoplasia and destruction of the left uncinate tract. In the children of group II with EE, hypoplasia of the anterior (63.6%) and posterior (65.9%) parts of the arcuate tract and the right uncinate tract (81.8%) was detected. Among children from group III, more than 60% had an abnormal location of Broca's speech center, and more than 70 % had an abnormal location of Wernicke's center, almost 80 % had an abnormal location of the left uncinate tract. Conclusions. It was found that in children with EE and DEE, according to MR tractography, there is a decrease in FA indicators and an increase in ADC in all studied structures (arcuate and uncinate tract, corpus callosum, thalamus) in comparison with the reference values given in the scientific literature. The detected changes indicate a violation of the structural integrity of the white matter in Broca's and Wernicke's centers and associative pathways, which will lead to the optimization of early diagnosis and prognosis of consequences in children with EE and DEE. The study was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committees of the institutions indicated in the work. The informed consent of the children's parents was obtained for conducting the research. No conflict of interest was declared by the authors.

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“…In animals, brain ASL-MRI has been used widely in experimental research ( 67–71 ). Recently, Hoffman et al successfully performed ASL in a large population of dogs and cats with a success rate of 95% in animals with a normal brain MRI.…”

Section: Techniquesmentioning

confidence: 99%

Magnetic resonance imaging in canine idiopathic epilepsy: a mini-review

Foss,

Billhymer

2024

Front. Vet. Sci.

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Magnetic resonance imaging (MRI) in an integral part of the diagnostic workup in canines with idiopathic epilepsy (IE). While highly sensitive and specific in identifying structural lesions, conventional MRI is unable to detect changes at the microscopic level. Utilizing more advanced neuroimaging techniques may provide further information on changes at the neuronal level in the brain of canines with IE, thus providing crucial information on the pathogenesis of canine epilepsy. Additionally, earlier detection of these changes may aid clinicians in the development of improved and targeted therapies. Advances in MRI techniques are being developed which can assess metabolic, cellular, architectural, and functional alterations; as well alterations in neuronal tissue mechanical properties, some of which are currently being applied in research on canine IE. This mini-review focuses on novel MRI techniques being utilized to better understand canine epilepsy, which include magnetic resonance spectroscopy, diffusion-weighted imaging, diffusion tensor imaging, perfusion-weighted imaging, voxel based morphometry, and functional MRI; as well as techniques applied in human medicine and their potential use in veterinary species.

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Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data

Cited by 11 publications

References 28 publications

Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy

Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy

Neuroimaging features of the nervous system in young children with epileptic encephalopathies according to MR-tractography

Magnetic resonance imaging in canine idiopathic epilepsy: a mini-review

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