Epileptiform EEG discharges in benign childhood epilepsy with centrotemporal spikes: Reactivity and transitory cognitive impairment

-There is much controversy about the importance of the electroencephalogram (EEG) in assessing the attention-deficit/hyperactivity disorder (ADHD). The objective of this study was to assess the use of EEG and quantitative EEG (qEEG) in ADHD children. Thirty ADHD children and 30 sex-and age-matched controls with no neurological or psychiatric problems were studied. The EEG was recorded from 15 electrode sites during an eyes-closed resting condition. Epileptiform activity was assessed, as were the absolute and relative powers in the classical bands after application of the Fast Fourier transform. Epileptiform activity was found in 3 (10%) ADHD children. As compared to the controls, the ADHD group showed significantly greater absolute delta and theta powers in a diffuse way, and also greater absolute beta power and smaller relative alpha 1 and beta powers at some electrodes. A logistic multiple regression model, allowed for 83.3% sensibility and specificity in diagnosing ADHD.KEy worDs: attention-deficit/hyperactivity disorder, EEG, children. Atividade epileptiforme e eletrencefalograma quantitativo em crianças com transtorno de déficit de atenção/hiperatividadeResumo -Há controvérsias sobre a importância do eletrencefalogama (EEG) na avaliação do transtorno de déficit de atenção/hiperatividade (TDAH). o objetivo deste estudo foi avaliar, em crianças com TDAH, o EEG digital e quantitativo. Foram estudadas 30 crianças com TDAH e 30 sadias, sem evidências de problemas neurológicos ou psiquiátricos e pareadas por idade e gênero. Foi registrado o EEG em 15 posições de eletrodos, durante repouso e olhos fechados. Foi realizada pesquisa de atividade epileptiforme e feita análise de freqüências nas faixas clássicas, após aplicação da transformada rápida de Fourier. Foi encontrada atividade epileptiforme em 3 (10%) crianças com TDAH. o grupo TDAH teve, em relação ao grupo controle, significativamente, maior potência absoluta delta e teta, de modo difuso, assim como maior potência absoluta beta e menor potência relativa alfa 1 e beta, em alguns eletrodos. Um modelo de regressão múltipla logística possibilitou sensibilidade e especificidade de 83,3% no diagnóstico de TDAH.PAlAvrAs-cHAvE: transtorno de déficit de atenção/hiperatividade, EEG, infância. The attention-deficit/hyperactivity disorder (ADHD) is one of the commonest behavioral disorders in childhood. Due to advancing knowledge with respect to the prevalence, natural history, genetics, biology and treatment of ADHD, a greater number of patients are now receiving adequate treatment. The diagnosis of ADHD is based on the DsM Iv 1 criteria of which the essential characteristic consists of a persistent pattern of lack of attention and/ or hyperactivity-impulsivity more frequent and serious than that typically observed in individuals with an equivalent developmental level. some symptoms of hyperactivity and impulsivity should be present up to 7 years of age. some compromise due to the symptoms should be present in at least two contexts (e.g. at home or at school ...

Section: Discussionmentioning

confidence: 96%

Epileptiform abnormalities and quantitative EEG in children with attention-deficit / hyperactivity disorder

Fonseca

Tedrus

Moraes

et al. 2008

“…Nevertheless, in a recent article reporting on an evaluation of children with BCECTS using DWPT, evidence was found showing a small percentage of the children with transitory cognitive impairment, but they did not show relevant cognitive impairment 15 .…”

Section: Dwpt and Aspects Of Epilepsy And Rsmentioning

confidence: 97%

“…The objective of the only other study about BECTS and DWPT 15 that included part of the present casuistry was to evaluate the presence of transitory cognitive impairment during RS, but it did not present the results for overall performance in the test. No studies were found on performance in a lexical decision task for children with BECTS.…”

Section: Dwpt and Bcectsmentioning

confidence: 99%

See 1 more Smart Citation

Benign childhood epilepsy with centrotemporal spikes: word and pseudoword discrimination

Fonseca

Oliveira

Ximenes

2009

-In the active phase of benign childhood epilepsy with centro-temporal spikes (BCECTS) there may be a fall in scholastic performance. Objective: To study lexical decision in children with BCECTS. Method: 42 children with BCECTS were compared with a control group with respect to their hits and response time in a visual discrimination of words and pseudowords task (DWPT). Results: The children with BCECTS had a lower percentage of hits for words and pseudowords and showed longer response times for pseudowords. They also frequently showed inferior reading and writing performance in the school performance test. The percentage of hits for pseudowords was lower when there was bilateral, asynchronous epileptiform activity. Conclusions: The DWPT provided contributions for reading assessments in children with BCECTS. The results indicated the need for attention in detecting reading difficulties in children with BCECTS.KEY WORDS: benign childhood epilepsy with centrotemporal spikes, rolandic epilepsy, EEG, epileptiform activity, reading, cognition. Epilepsia benigna da infância com pontas centro-temporais: discriminação entre palavras e pseudopalavrasResumo -Na fase ativa da epilepsia benigna da infância com pontas centrotemporais (EBICT) pode ocorrer queda de desempenho escolar. Objetivo: Estudar a decisão lexical em crianças com EBICT. Método: 42 crianças com EBICT foram comparadas a grupo controle quanto a acertos e tempo de resposta em tarefa de discriminação visual entre palavras e pseudopalavras (DVPPS). Resultados: As crianças com EBICT tiveram percentual menor de acertos para palavras e pseudopalavras e maior tempo de resposta para pseudopalavras e tiveram, mais frequentemente, desempenho inferior em escrita e leitura em teste de desempenho escolar. Houve relação significativa entre os resultados do DVPPS e o teste de desempenho escolar. A percentagem de acerto de pseudopalavras foi menor quando havia atividade epileptiforme bilateral e assíncronia no

“…However, subtle neuropsychological deficits, behavioral disturbances, and difficulties in school performance, particularly in relation to reading and writing skills, may occur. It is still not clear if these abnormalities can be observed only in the active phase of epilepsy 4,5 , that is, if the transitory cognitive impairments occur exclusively during subclinical epileptiform discharges [6][7][8] . On the other hand, evidence suggest that such abnormalities are observed both before the active phase and during the postactive phase of epilepsy 9 .…”

mentioning

confidence: 99%

Clinical and neuropsychological correlation in patients with rolandic epilepsy

Capelatto

Oliveira

Neri

et al. 2012

OBJECTIVES: To evaluate the presence of neurological soft signs (NSS) and to correlate them with the Wechsler Intelligence Scale for Children (WISC III) in patients with rolandic epilepsy (RE). METHODS: Forty children and adolescents aged between 9 and 15 years were studied. They were divided into two groups: G1 - patients with RE (n=20) - and G2 - healthy controls without epilepsy (n=20). They were assessed with the Quick Neurological Screening Test (QNST II) - clinical trial to search for NSS -, and the WISC III - neuropsychological test. RESULTS: No statistical difference between groups was found in WISC III and QNST II. However, children with poorer motor skills had worse performance in the QNST II and also in the execution intelligence quotient - IQ (p=0.001) and in total IQ (p=0.004), thus showing a positive correlation between them. CONCLUSIONS: The QNST II is a good screening tool for the neurologist to detect abnormalities in fine motor skills.