Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations

Fan, Joline M.; Khambhati, Ankit N.; Sellers, Kristin K.; Stapper, Noah; Maya, Daniela Astudillo; Kunwar, Elysha; Henderson, Catherine; Sugrue, Leo P.; Chang, Edward F.; Rao, Vikram R.; Krystal, Andrew D.

doi:10.1016/j.brs.2023.02.006

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“…Safety surveys were performed at 1 and 100 Hz, 100 μs pulse width, and increasing currents (1–6 mA). For each patient, brain regions and stimulation parameters that elicited epileptiform discharges were avoided in all subsequent experimental stimulation paradigms with longer-duration stimulation [ 37 ] (see Supplementary Methods ).…”

Section: Methodsmentioning

confidence: 99%