Epileptic seizures after a first stroke: the Oxfordshire community stroke project

Burn, John; Dennis, Martin; Bamford, John; Sandercock, Peter; Wade, Derick; Warlow, Charles

doi:10.1136/bmj.315.7122.1582

Cited by 367 publications

(356 citation statements)

References 34 publications

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confidence: 99%

“…5 The authors of most large studies of seizures after stroke have focused either on ischemic and hemorrhagic stroke together or hemorrhagic stroke exclusively. 1,[4][5][6] However, few researchers have examined the clinical features of seizures in patients who have had spontaneous ICH. 3,9,14,15,19 The majority of previous studies have included relatively few patients, 9,14 less strict selection, and included seizures that occurred only in the acute phase of spontaneous ICH or during a shorter follow-up period.…”

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Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Yang¹,

Lin

Chang

et al. 2009

JNS

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Object. Seizures are an important neurological complication of spontaneous intracerebral hemorrhage (ICH).A better understanding of the risk factors of seizures following ICH is needed to predict which patients will require treatment.Methods. Two hundred and forty-three adult patients were enrolled in this 1-year retrospective study. Multiple logistic regression was used to evaluate the relationship between baseline clinical factors and the presence or absence of seizure during the study period.Results. Seizures occurred in 20 patients with ICH, including acute symptomatic seizures in 9 and unprovoked seizures in 11. None progressed to status epilepticus during hospitalization. After a minimum 3-year follow-up period, the mean Glasgow Outcome Scale score was 3.8 ± 1.1 for patients who had had seizures and 3.5 ± 1.3 for those who had not. The multiple logistic regression model demonstrated that the mean ICH volume was independently as sociated with seizures, and any increase of 1 mm 3 in ICH volume increased the seizure rate by 2.7%. Conclusions. Higher mean ICH volumes at presentation were predictive of seizure, and the presence of late seizures was predictive of developing epilepsy. Most seizures occurred within 2 years of spontaneous ICH over a minimum of 3 years of follow-up. (DOI: 10.3171/2009.2.JNS081622) KeY WorDs • outcome • risk factor • seizure • spontaneous intracerebral hemorrhage 87Abbreviations used in this paper: AED = antiepileptic drug; GCS = Glasgow Coma Scale; GOS = Glasgow Outcome Scale; ICH = intracerebral hemorrhage; ROI = region of interest.

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confidence: 99%

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confidence: 99%

Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Yang¹,

Lin

Chang

et al. 2009

JNS

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“…[6,7] Serebral iskemi veya hemoraji sonrası gelişen nöbetlerin sıklığı ile ilgili değişik çalışmalarda %4.4 ile %42.8 arasında birçok değişik oran bildirilmiştir. [6,8,9] Bunun nedeni yapılan araştırmaların çalışma protokollerinin, hasta seçiminin, BDH tiplerinin, takip sürelerinin farklı olmasıdır. [10] İnme sonrası ortaya çıkan nöbetler, erken ve geç dönem olarak ikiye ayrılmaktadır.…”

Section: Discussionunclassified

Early and Late Onset Seizures After Cerebrovascular Disease

Özkan¹

2015

Epilepsi

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“…La epilepsia es más común en países en vías de desarrollo (13)(14)(15)(16)(17), con prevalencias estimadas ajustadas a la edad entre 2,7/1000 a 17,6/ 1000 habitantes, y con rangos de incidencia de 16/ 100 000 a 51/ 100 000 habitantes (13). Su mayor incidencia ocurre en los extremos de la vida.…”

Section: Epidemiologíaunclassified

“…Al evaluar el riesgo anual acumulativo encontraron que después de un ictus isquémico este fue de 4,2 % (95 % IC, 2,2 a 6,2) al primer año y de 9,7 % a los cinco años (95 % IC, 3,7 a 15.7); después de una hemorragia intracerebral primaria este fue de 19,9 % (95 % IC, 1.5 a 38,3) al primer año y de 26,1 % a los cinco años (95 % IC, 3,7 a 15,7); y después de hemorragia subaracnoidea 22 % (95 % IC, 2,6 a 41,8) al primer año y de 34,3 % a los cinco años (95 % IC, 0 a 100) (17).…”

Section: Epidemiologíaunclassified

Epilepsia post ictus.

Toro-Pérez¹,

Villafuerte²,

Burneo³

2013

Rev Neuropsiquiatr

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RESUMENEn las personas mayores de 60 años, el ictus es la causa más frecuente de epilepsia. La tasa global de epilepsia post ictus varía del 2% al 4%. La localización cortical y el tamaño de la isquemia son los factores que están asociados con crisis epilépticas post ictus. Las crisis epilépticas de inicio tardío se asocian frecuentemente con el desarrollo de epilepsia post ictus, siendo su principal manifestación clínica las convulsiones parciales con generalización secundaria. Además de los estudios de imagen, el electroencefalograma es de considerable ayuda durante el inicio de crisis, así como durante el seguimiento, donde el patrón más frecuente son ondas lentas focales. El tratamiento con drogas antiepilépticas debe iniciarse con bajas dosis, y lentamente incrementarlas hasta alcanzar la dosis efectiva. Los nuevos fármacos son los preferidos, debido a su baja tasa de efectos colaterales.PALABRAS CLAVE: Epilepsia, ictus, accidente cerebrovascular, ataque cerebrovascular, convulsiones SUMMARYIn people over 60 years, stroke is the most frequent cause of epilepsy. The overall rate of post-stroke epilepsy varies from 2% to 4%. The location and size of cortical ischemia are among the factors associated with poststroke seizures. Late -onset seizures are more frequent associated with the development of post stroke epilepsy, being its main clinical manifestations partial seizures with secondary generalization. In addition to imaging studies,electroencephalography is of considerable assistance during the initial period and during follow-up, where the most common pattern is focal slowing. Antiepileptic drug treatment should be started at low doses and slowly be increased until effective doses are reached. Newer antiepileptic drugs are preferred due to their low rate of side effects.

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Epileptic seizures after a first stroke: the Oxfordshire community stroke project

Cited by 367 publications

References 34 publications

Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Early and Late Onset Seizures After Cerebrovascular Disease

Epilepsia post ictus.

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