Epileptic disorders with onset in the first year of life: neurological and cognitive outcome

Battaglia, Domenica; Randò, Teresa; Deodato, Federica; Bruccini, G.; Baglio, Gisella; Frisone, Maria Flavia; Pantó, T.; Tortorella, Gaetano; Guzzetta, F

doi:10.1016/s1090-3798(99)90096-x

Cited by 28 publications

(28 citation statements)

References 25 publications

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“…Because age of onset and seizure duration have been shown to be predictors of cognitive function in epilepsy (42)(43)(44)(45)(46)(47)(48), additional analyses examined the effect of these variables, across pathology, on cognitive performance. A stepwise regression analysis with age of onset and duration showed that only the seizure duration was a significant predictor of VIQ (P ϭ 0.00, R 2 ϭ 0.150), PIQ (P ϭ 0.008, R 2 ϭ 0.127), FSIQ (P ϭ 0.003, R 2 ϭ 0.155), and PPVT (P ϭ 0.038, R 2 ϭ 0.124), but not of performance on the other cognitive tasks.…”

Section: Seizure Onset and Durationmentioning

confidence: 99%

Single and Dual Pathologies of the Temporal Lobe: Effects on Cognitive Function in Children with Epilepsy

Bigel

Smith

2001

Epilepsy & Behavior

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Section: Seizure Onset and Durationmentioning

confidence: 99%

Single and Dual Pathologies of the Temporal Lobe: Effects on Cognitive Function in Children with Epilepsy

Bigel

Smith

2001

Epilepsy & Behavior

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“…Clinical experience indicates that not all seizures or epilepsy syndromes are alike in their associated neurological morbidity. For example, there seems to be little residual effect of childhood absence seizures on cognitive or neurological function (66,67), though even this point may be debated (68). One might argue that these attacks are nonconvulsive, but if that were the critical characteristic, one would not expect the cognitive decline often seen in association with recurrent complex partial attacks.…”

Section: What Factors Might Determine Whether a Particular Human Epilmentioning

confidence: 99%

Is Epilepsy a Progressive Disease? The Neurobiological Consequences of Epilepsy

Cole

2000

Epilepsia

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Summary: While primary, or idiopathic, epilepsies may exist, in the vast majority of cases epilepsy is a symptom of an underlying brain disease or injury. In these cases, it is difficult if not impossible to dissociate the consequences of epilepsy from the consequences of the underlying disease, the treatment of either the disease or the epilepsy, or the actual seizures themselves. Several cases of apparent complications of epilepsy are presented to illustrate the range of consequences encountered in clinical practice and the difficulty in assigning blame for progressive symptomatology in individual cases. Because of the difficulty in interpreting clinical material, many investigators have turned to epilepsy models in order to address the potential progressive consequences of recurrent seizures. The authors review experimental data, mainly from animal models, that illustrate short-, medium-, and long-term morphological and biochemical changes in the brain occurring after seizures, and attempt to relate these observations to the human condition.

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“…Some studies do exist (e.g. Battaglia et al , 1999), but the focus in them has been on medical aspects and the remission of seizures rather than on the psychological outcome. Some studies with psychological assessments have been conducted (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The epilepsy related factors contributing to the neurocognitive impairment in children with epilepsy include the underlying etiology and neuropathology, electroencephalographic (EEG) discharges and seizures, and antiepileptic drugs (Nieminen & Eriksson, 2008). An early onset, long duration of the disease and poor seizure control are generally associated with poor cognitive outcome (Battaglia et al , 1999; Elger et al , 2004; Mangano, Fontana, & Cusumano, 2005). Cognitive functions may already be impaired at the onset of epilepsy (Kolk, Beilmann, Tomberg, Napa, & Talvik, 2001; Oostrom, Smeets‐Schouten, Kruitwagen, Peters, & Jennekens‐Schinkel, 2003).…”

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confidence: 99%

Neurocognitive functioning of preschool children with uncomplicated epilepsy

Rantanen

Nieminen

Eriksson

2010

Journal of Neuropsychology

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Only few studies are available on the cognitive functioning of preschool children with uncomplicated epilepsy. The aim of this study was to describe the neurocognitive functioning of 3-6-year-old children with uncomplicated epilepsy. A subgroup of children with uncomplicated epilepsy from a population based cohort of preschool children with active epilepsy (N=64) participated in the study. The neurocognitive functioning of these children (N=13) was compared to that of matched healthy controls (N=13). The Wechsler's Primary and Preschool Scale of Intelligence - Revised and the Developmental Neuropsychological Assessment were administered. The intellectual functioning of the children with uncomplicated epilepsy was within normal range, but differed significantly from that of healthy controls, which was contrary to expectations. Statistically significant differences emerged between the study and the control group in Verbal IQ and Full Scale IQ, but no differences were found in Performance IQ. The children with uncomplicated epilepsy also had minor neurocognitive difficulties in verbal short-term memory (p<.01) compared to healthy children. The result suggests that uncomplicated epilepsy in preschool children may interfere with language and verbal short-term memory functions. Further studies with detailed neuropsychological assessments and follow-up time are needed to gain more insight into the developmental course of children with uncomplicated epilepsy. Also, because of the developmental risks reported in this study, psychological screening and detailed neuropsychological assessment are recommended in clinical practice.

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Epileptic disorders with onset in the first year of life: neurological and cognitive outcome

Cited by 28 publications

References 25 publications

Single and Dual Pathologies of the Temporal Lobe: Effects on Cognitive Function in Children with Epilepsy

Single and Dual Pathologies of the Temporal Lobe: Effects on Cognitive Function in Children with Epilepsy

Is Epilepsy a Progressive Disease? The Neurobiological Consequences of Epilepsy

Neurocognitive functioning of preschool children with uncomplicated epilepsy

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