Epileptic and cognitive changes in children with cerebral palsy: an Egyptian study

El-Tallawy, Hamdy N; Farghaly, Wafaa Ma; Shehata, Ghaydaa A.; Badry, Reda; Rageh, Tarek A.

doi:10.2147/ndt.s59600

Cited by 12 publications

(6 citation statements)

References 28 publications

(45 reference statements)

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“…Epilepsy is common in cerebral palsy, present in 30%–40% of cases [ 4 , 16 ], and seizures are reported on 35.5% of CP children in the hemiplegia subgroup [ 15 ]. In the 93 children analyzed in the present study, the incidence of epilepsy was calculated to be 49%, on average higher than that reported in the literature [ 16 , 17 , 18 ]. The difference in the frequency of CP-epilepsy association may depend on the selection of the cases.…”

Section: Discussioncontrasting

confidence: 68%

“…In terms of children with CP, grey matter lesions are more common. As suggested by El-Tallawy et al [ 18 ], neonatal seizures can be a strong predictor of epilepsy in cerebral palsy. Sadowska et al [ 19 ] investigated 181 children with CP and selected 102 children affected by epilepsy (56.35%); among this group, 44 (43%) had drug-resistant epilepsy and only 15 (14.71%) were responsive to treatment.…”

Section: Discussionmentioning

confidence: 96%

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Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

et al. 2020

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Cerebral palsy (CP) is a frequent cause of childhood disability often associated with a complex group of disorders, including epilepsy, which is reported to impact approximately 40% of affected individuals. This retrospective study involved a group of children affected by CP, some of whom also had comorbid epilepsy. The aim of this study was to report our experience of analyzing, in particular, (a) some of the clinical aspects of the different type of CP, and (b) the relationship between the clinical data of children affected by CP plus epilepsy and each type of CP. Methods: This retrospective single-center study was performed with 93 children admitted to the Pediatric Department of the University of Catania, Italy, affected by CP and distinguished according to the type of motor clinical presentation, with 46 showing epileptic seizures, compared to a control group of 136 children affected by epilepsy without other neurologic disorders. Results: Among the 93 CP children, 25 (27%) had spastic quadriplegia (plus one patient with dystonic quadriplegia), 39 (42%) had spastic hemiplegia, 11 (12%) had spastic diplegia (plus two with ataxia and one with dyskinetic CP), and 14 (15%) did not have a well-defined type of CP. The frequency of epilepsy was higher in affected CP children who showed major motor dysfunction (GMFCS IV–V types). As regards the 46 children with CP plus epilepsy, compared to the group of the control, the age of epilepsy onset was found to be statistically significant: 21 ± 35.1 months vs. 67 ± 39.7. Conclusions: Epilepsy represents one of the most frequent comorbidities of cerebral palsy. In children with CP, particular attention should be paid to the early identification and treatment of comorbid epilepsy.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 96%

Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

et al. 2020

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“…More CP patients with epilepsy had a history of neonatal seizures than non-epilepsy patients. Previous studies by Karatoprak et al [6], Kulak and Sobaniec [16], and El-Tallawy et al [7] also showed that neonatal seizures were a risk factor for epilepsy. An association between epilepsy and history of febrile seizures was observed in our study.…”

Section: Risk Factors For Epilepsy In Cerebral Palsymentioning

confidence: 87%

“…had epilepsy [5][6][7][8][9][10]. The prevalence of epilepsy in the general population is 3 to 8 per 1,000 persons, and the prevalence in patients with CP is higher than that [8,9,11,12].…”

mentioning

confidence: 99%

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Yeo,

Han,

Kim

2023

Ann Child Neurol

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Purpose: The aim of this study was to describe the characteristics of epilepsy in cerebral palsy (CP) patients and identify risk factors for epilepsy and drug-resistant epilepsy.Methods: CP patients aged 18 years old or younger who visited the pediatric neurology department and/or rehabilitation department of a tertiary care hospital between January 2016 and December 2022 with a minimum follow-up period of 2 years were included. Demographic and clinical data, seizure characteristics, brain imaging, electroencephalography, and genetic evaluation results were reviewed retrospectively.Results: Among 268 patients included in this study, 36.9% had epilepsy and 10.8% had drug-resistant epilepsy. Asphyxia (29.3%), hemorrhage, infarction, and brain infection (25.3%) were associated with epilepsy. Epileptic CP patients were more likely to experience neonatal seizures (18.2% vs. 4.1%, <i>P</i><0.001) and febrile seizures (12.1% vs. 7.1%, <i>P</i>=0.02) than non-epilepsy CP patients. The most common cerebral subtype in patients with epilepsy was spastic quadriplegia (59.6%). Epilepsy patients were more severely impaired in gross motor function, with worse intellectual disability. Patients with macrocephaly or cerebral malformation were more likely to have drug resistance. Valproate (51.7% and 25.7%) and levetiracetam (41.4% and 25.7%) were the two most commonly used antiseizure medications, both in monotherapy and polytherapy.Conclusion: A history of asphyxia, febrile seizure, neonatal seizure, spastic quadriplegia, more severely impaired gross motor function, and intellectual disability were found to be risk factors for epilepsy. Further research with prospective data collection to develop a model for predicting seizures or epilepsy in CP patients is needed.

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“…This difference may depend on case selection, where the frequency of epilepsy is greater in the group of CP subjects with spastic quadriplegic type, and with more severe motor dysfunction, as reported in the literature, which may be a reflection of the severity of damage to the brain. (20)(21)(22) The prevalence of vitamin D deficiency in children with cerebral palsy varies throughout the world. In this study, of 85 children with cerebral palsy, 54.1% had deficiency, and 29.4% had vitamin D insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile and Vitamin D Status of Cerebral Palsy Children at Haji Adam Malik Hospital Medan

Yusnita,

H.Saing,

Buana Nasution

2024

IJRP

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Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain development. Children with CP are at risk of experiencing vitamin D deficiency due to reduced mobility, low vitamin D intake, and use of anti-epileptic drugs. Vitamin D deficiency can cause hypocalcemia and reduce bone mineral density, osteopenia, and rickets so that it can result in pathological fractures even with only minor injuries. Monitoring vitamin D levels, early identification, and appropriate vitamin D supplementation are important in reducing the risk of injury and fracture in PS children. This study aims to determine the clinical profile of children with cerebral palsy and their vitamin D status. Methods: A descriptive study of children with cerebral palsy aged 2 to 6 years at the Neuro-pediatric outpatient clinic at H. Adam Malik Hospital, Medan from November 2022 to April 2023. Primary data was obtained from interviews and examination of serum vitamin D levels. Secondary data was obtained from medical records. Results: Eighty-five CP children were included in this study, 51.8% were boys and 48.2% were girls. The mean age of the subjects was 3.48 years, 34.1% of the subjects experienced malnutrition. The etiology of CP mainly occurs in the perinatal period (66.7%). Most subjects had spastic type (75.3%), with GMFCS grade V being the most common type (34.1%). Most of the subjects (57.6%) had epilepsy and were using anti-epileptic drugs. The majority of subjects had vitamin D deficiency status (56.5%). Conclusion:The clinical profile of cerebral palsy children at Haji Adam Malik Hospital Medan showed that most CP occurred during the perinatal period. Spastic type is the most common type of CP, most CP children experience epilepsy and vitamin D deficiency.

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Epileptic and cognitive changes in children with cerebral palsy: an Egyptian study

Cited by 12 publications

References 28 publications

Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Clinical Profile and Vitamin D Status of Cerebral Palsy Children at Haji Adam Malik Hospital Medan

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