Epilepsy in multiple sclerosis

Cendrowski, W; Majkowski, J

doi:10.1016/0022-510x(72)90151-7

Cited by 32 publications

(29 citation statements)

References 9 publications

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“…Drake and Macrae [5] define their series as 'pa tients with a secure diagnosis of multiple sclerosis'. In spite of these limits, more recent papers agree with the first observations, reporting a figure of 3% [16] [21] found a prevalence of 1.1, higher than the expected figure of 0.5 of the general population. We found a prevalence of 1.7% in the over all series of 2,353 patients, but the prevalence raised to 2.3% in definite MS patients, confirming the finding that MS increases the risk of developing epilepsy.…”

Section: Discussionsupporting

confidence: 56%

“…The prognostic significance of seizures on MS course has been differently evaluated in previous studies: some authors [10,16,17] have found that epilepsy is some times associated to a malignant course, but it is not clear whether it represents a casual association. In our series, the frequency of seizures was not significantly correlated to a particular type of evolution nor to MS severity.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies on allergic encephalomyelitis in animals have demonstrated that paroxysmal EEG changes and generalized seizures can occur in relation to edema, neuronal and glial damage [34], The role of ede ma, inflammatory and glial reaction have also been admitted in MS epileptic patients [10,16,17],…”

Section: Discussionmentioning

confidence: 99%

“…Only a few extended studies are avail able on the prevalence of epilepsy in MS, which is reported to vary from 0.45% [14] up to 10.8% [15] (fora review of data up to 1961, see [5]). Other unresolved questions are the prognostic value of seizures on MS course, the clinic-pathologic correlation, the possible particular pattern of seizures and electroencephalogram (EEG) [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Epilepsy in Multiple Sclerosis

Ghezzi

Montanini²,

Basso³

et al. 1990

Eur Neurol

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In a series of 2,353 multiple sclerosis (MS) patients, 40 subjects presented seizures, with an overall prevalence of 1.70%. The prevalence was 2.33% (34/1,459) in definite MS cases, 0.58 in probable cases (3/518), 0.79 in possible cases (3/376). Twenty-six patients were females, 14 were males. In 13 cases, epilepsy had begun before MS onset; in 4 patients, the two diseases started contemporarily; in 23 patients, epilepsy followed MS onset. No relationship was found between frequency of seizures and course of MS nor between frequency of seizures and MS severity. In 12 patients, magnetic resonance imaging was performed: plaques adjacent to the cerebral cortex were found in 3 cases. The electroencephalogram showed paroxysmal discharges in 11 patients (focal in 2, diffuse in 9). Slow theta and/or delta activity was found in 15 patients (focal in 7, diffuse in 6, both focal and diffuse in 2). The EEG was normal in 14 patients. Possible etiological factors other than MS were recognized in 4 patients only: cranial trauma in 3, meningitis in 1. Our study on a large MS population confirms that MS is associated to a risk for epilepsy higher than that of the general population.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epilepsy in Multiple Sclerosis

Ghezzi

Montanini²,

Basso³

et al. 1990

Eur Neurol

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“…[8] Lebrun, [9] MS hastalarındaki epileptik nöbet sıklığının MS alevlenmeleri ile ilişkili olduğunu göster-miştir. Multipl skleroz ataklarında ortaya çıkan epileptik nö-betler özel bir durum meydana getirir.…”

Section: Discussionunclassified

Epileptic Seizure as First Presenting Symptom of Multiple Sclerosis: A Case Report

Balcı¹

2016

Epilepsi

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Epileptik nöbetler multipl skleroz (MS) hastalığının seyrinde görülebilmektedir. Ancak MS'nin ilk semptomunun nöbet olması son derece nadirdir. Bu yazıda ilk atağı epilepsi nöbetiyle ortaya çıkan 26 yaşında MS'li bir kadın sunulmaktadır. Hasta acile jeneralize tonik klonik nö-betle başvurdu. Nörolojik muayenede sağ hemiparezi bulguları ve hiperaktif derin tendon refleksler dışında özellik saptanmadı. Kraniyal manyetik rezonans görüntülemesinde periventriküler yerleşimli, çok sayıda milimetrik lezyon ve sol sentrum semiovalede 45x27 mm çaplı, yarım halka şeklinde kontrast tutan, kortikal, T2/FLAİR kesitlerde hiperintens lezyon izlendi. Beyin omurilik sıvısı incelemelerinde IgG indeksi yüksek, oligoklonal band (+) idi. Elektroensefalografide sol hemisfer fronto-temporal bölgede belirgin keskin dalga paroksizmleri gözlendi. Multipl skleroz tanısı konuldu ve pulse kortikosteroid verildi. Tekrarlayan nöbetleri nedeniyle hastaya antiepileptik tedavi başlandı. Nöbetler monoterapi ile kontrol altına alındı. Multipl sklerozlu hastaların nöbet geçirebildiği bilinmektedir. Nöbetle başvuran özellikle genç olgularda ayırıcı tanıda multipl skleroz mutlaka akla getirilmelidir.Anahtar sözcükler: Epilepsi; multipl skleroz; nöbet. SummaryWhile epileptic seizures are seen in the course of multiple sclerosis, they are rarely the first symptom. The first epileptic seizure of a 26-yearold woman with multiple sclerosis is described in the present report. The patient presented to the emergency department with generalized tonic-clonic seizure. Neurologic examination was normal except for right-sided hemiparesis and hyperactive deep tendon reflexes. Cranial MRI revealed periventricular, multiple millimetric lesions and a 45x27-mm, semi-ring-enhanced, cortical, T2/FLAIR, hyperintense lesion in the centrum semiovale. IgG index was high, and oligoclonal band was positive in cerebrospinal fluid examination. Electroencephalography showed prominent fronto-temporal activity on the left side and sharp wave paroxysms. Multiple sclerosis was diagnosed, and pulse corticosteroid therapy was initiated. Due to recurrent seizures, antiepileptic drug was added to treatment; seizures were controlled with monotherapy. It is known that patients with multiple sclerosis experience seizures. Multiple sclerosis should be considered in the differential diagnosis of young patients presenting with seizures.

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Epilepsie und Multiple Sklerose

Runge¹

2001

Multiple Sklerose

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Epilepsy in multiple sclerosis

Cited by 32 publications

References 9 publications

Epilepsy in Multiple Sclerosis

Epilepsy in Multiple Sclerosis

Epileptic Seizure as First Presenting Symptom of Multiple Sclerosis: A Case Report

Epilepsie und Multiple Sklerose

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