Epilepsy in low‐grade gliomas: The impact on cognitive function and quality of life

Klein, Martin; Engelberts, Nadine H. J.; Ploeg, Henk M. van der; Trenité, Dorothee Kasteleijn‐Nolst; Aaronson, Neil K.; Taphoorn, Martin J.B.; Baaijen, Hans; Vandertop, W. Peter; Müller, Martin; Postma, Tjeerd J.; Heimans, Jan J.

doi:10.1002/ana.10712

Cited by 375 publications

(264 citation statements)

References 26 publications

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“…It would be n e c e s s a ry to develop a clinical paradigm to early identify patients with GG. Early diagnosis might provide a better chance of total tumor removal and re m i ssion of epilepsy 1,33,34 .…”

Section: Discussionmentioning

confidence: 99%

Ganglioglioma: comparison with other low-grade brain tumors

Brainer-Lima

Filho

2006

Arq. Neuro-Psiquiatr.

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-Method: F o rty-two patients with low-grade brain tumor and re f r a c t o ry epilepsy were studied. The mean age was 22.3 years. They were divided into two groups: Group A, patients with ganglioglioma (n=19) and group B, patients with other low-grade tumors (n=23) (14 astrocytoma, 6 oligodend roglioma, 2 dysembryoplastic neuroepithelial tumor, and 1 xanthoastro c y t o m a ) . Results: Age at seizure 's onset was 7 years or less in 73% of the patients in group A and in 30.4% of the patients in group B (p=0.045). Complex partial occurred frequently in group A and B (94.7% versus 82%, respectively). Seizure 's fre q u e ncy was higher in group B (p=0.002).Computerized tomography (CT) was normal in 36.8% of group A patients and abnormal in all group B patients. Magnetic resonance imaging (MRI) was abnormal in all patients. S u rgical removal was complete in 89.5% of the patients in group A and in 78.2% of the patients in gro u p B . Conclusion: The association of re f r a c t o ry epilepsy and complex partial seizures, at a relatively low freq u e n c y, in young patients potentially normal CT and a MRI hypointense temporal lobe lesion in T1-weighed slices were habitual image findings in ganglioglioma, rather than other low-grade tumor.KEY WORDS: ganglioglioma, refractory epilepsy, low-grade brain tumors.Ganglioglioma: estudo comparativo com outros tumores cerebrais primarios de baixo grau RESUMO -Método: Foram estudados 42 pacientes com tumor cerebral primário de baixo grau e epilepsia refratária. A idade média foi 22,3 anos. Eles foram divididos em dois grupos: no grupo A os pacientes com ganglioglioma (n=19) e no grupo B os pacientes com outros tumores primários de crescimento lento (n=23) (14 astrocitomas, 6 oligodendrogliomas, 2 tumores desembrioblástico neuroepitelial e um xantoastro c i t om a ) . Resultados: A idade de início das crises convulsivas foi 7 anos ou menos em 73% dos pacientes no g rupo A e 30,4% dos pacientes no grupo B (p=0,045). A crise convulsiva do tipo parcial complexa foi a mais identificada nos grupos A e B (94,7% versus 82%, respectivamente). A freqüência de crise foi mais alta no g rupo B (p=0,002). A tomografia computadorizada foi normal em 36,8% dos pacientes no grupo A e anormal em todos no grupo B. A ressonância magnética foi anormal em todos os pacientes. A remoção cirúr-gica foi completa em 89.5% dos pacientes no grupo A e 78,2% no grupo B. Conclusão: A associação de epilepsia refratária e crise parcial complexa, principalmente quando a freqüência não é muito alta, em pacientes jovens, mesmo com tomografia computadorizada normal e alteração hipointensa na seqüência de T1 da ressonância magnética é sugestiva de ganglioglioma mais que outros tipos de tumor cere b r a l primário de baixo grau. PALAVRAS-CHAVE: ganglioglioma, epilepsia refratária, tumor cerebral de baixo grau.Ganglioglioma (GG) is one of the commonest causes of tumor-related re f r a c t o ryepilepsy in young pat i e n t s 1 , and together with other low-grade brain neop l a s m 's, comprises 10-30% of the ...

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Section: Discussionmentioning

confidence: 99%

Ganglioglioma: comparison with other low-grade brain tumors

Brainer-Lima

Filho

2006

Arq. Neuro-Psiquiatr.

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“…Despite these methodological limitations, the studies conducted to date suggest that many survivors of LGG suffer from cognitive deficits, assessed both objectively and subjectively, and compromised HRQOL, for example, increased fatigue or depression [27][28][29][30][31]. Lower HRQOL in long-term LGG survivors is related to the extent of cognitive deficit and the severity of epilepsy [32]. Of note, the overall HRQOL in LGG survivors is not different from that in patients with hematological malignancies without involvement of the central nervous system (N.K.…”

Section: Hrqol In Glioma Patientsmentioning

confidence: 99%

“…Neurological signs and symptoms, such as seizure frequency, motor deficits, and functional status, have been proven to diminish HRQOL [19,32,36]. Surprisingly, no deleterious effect of dysphasia on HRQOL has been established [36].…”

Section: Hrqol In Glioma Patientsmentioning

confidence: 99%

Review on Quality of Life Issues in Patients with Primary Brain Tumors

2010

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Health-related quality of life (HRQOL) has become an important outcome measure in clinical trials in primary brain tumor (i.e., glioma) patients, because they have an incurable disease. HRQOL is assessed using self-reported, validated questionnaires, addressing physical, psychological, emotional, and social issues. In addition to generic HRQOL instruments, disease-specific questionnaires have been developed, including for brain tumor patients. For the analysis and interpretation of HRQOL measurements, low compliance and missing data are methodological challenges. HRQOL in glioma patients may be negatively affected by the disease itself as well as by side effects of treatment. But treatment with surgery, radiotherapy, and chemotherapy may improve patient functioning and HRQOL, in addition to extending survival.Although HRQOL has prognostic significance in brain tumor patients, it is not superior to well-known clinical parameters, such as age and performance status. In clinical practice, assessing HRQOL may be helpful in the communication between doctor and patient and may facilitate treatment decisions. The Oncologist 2010;15:618 -626

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“…Although the cognitive effects of chemo therapy are less clear, they might result from comparable mechanisms [21,22]. Antiepileptic drugs also have adverse effects [11,14,15,20,23]. Other medical factors and complications, including endocrine and metabolic disturbances, infection and anemia, can also contribute to the cognitive deficits [24][25][26].…”

Section: Abstract: Brain Tumor • Cognitive Deficits • Cognitive Rehabmentioning

confidence: 99%