Epilepsy Following Radical Removal of Parasagittal and Convexity Meningiomas

Flyger, G.

doi:10.1111/j.1600-0447.1956.tb09690.x

Cited by 10 publications

(1 citation statement)

References 4 publications

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“…For example, Olivecrona's 22 experience with 112 convexity meningiomas, published in 1967, reveals a 25% incidence of new-onset postoperative epilepsy. Similarly, Flyger's 11 1956 series of 94 convexity meningiomas demonstrated a new-onset postoperative epilepsy rate of 9.6%. In contrast, seizure disorders attributable to microsurgical removal are rarely encountered in the modern era, likely due to advances in microsurgical technique as well as the routine use of postoperative antiepileptics.…”

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confidence: 99%

Risk profile associated with convexity meningioma resection in the modern neurosurgical era

Sanai¹,

Sughrue²,

Shangari³

et al. 2010

JNS

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Object. Although meningiomas are commonly found along the supratentorial convexity, the risk profile associated with this subset of lesions in the modern neurosurgical era is unknown.Methods. The authors retrospectively reviewed the clinical course of patients with supratentorial convexity meningiomas treated during the past 10 years. All patients had undergone MR imaging within 72 hours after surgery and at least 1 year of clinical follow-up. Patients with multiple meningiomas, hemangiopericytomas, malignant meningiomas, or tumor-prone syndromes were excluded from analysis.Results. Between 1997 and 2007, 141 consecutive patients (median age 48 years, range 18-95 years) underwent resection of a supratentorial convexity meningioma. The most common signs or symptoms at presentation were headache (48%), seizures (34%), and weakness (21%). The mean tumor volume was 146.3 cm 3 (range 1-512 cm 3). There were no intraoperative complications or deaths. Medical or neurosurgical morbidity was noted in the postoperative course of 14 patients, equating to a 10% overall complication rate. Postoperative surgical complications included hematoma requiring evacuation, CSF leakage, and operative site infection. Medical complications included pulmonary embolus and deep vein thrombosis requiring treatment. A Simpson Grade 0 or 1 resection was achieved in 122 patients (87%). One hundred six tumors (75%) were WHO Grade I, whereas 35 (25%) were WHO Grade II. The median clinical follow-up was 2.9 years (range 1-10 years), and the median radiographic follow-up was 3.7 years (range 1-10 years). Six patients (4%) had radiographic evidence of tumor recurrence, with 3 (2%) undergoing repeat resection.Conclusions. With the conservative recommendations for surgery for asymptomatic meningiomas and the advent of radiosurgery during the past 10 years, microsurgically treated convexity meningiomas are now typically large in size. Nevertheless, the patient's clinical course following microsurgical removal of these lesions is expected to be uncomplicated. The authors' findings provide a defined risk profile associated with the resection of supratentorial convexity meningiomas in the modern neurosurgical era.

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confidence: 99%

Risk profile associated with convexity meningioma resection in the modern neurosurgical era

Sanai¹,

Sughrue²,

Shangari³

et al. 2010

JNS

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Meningiomas and Epilepsy

González-Martínez

Najm

2009

Meningiomas

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Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours

et al. 1990

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One hundred and twenty-eight adult patients presenting with and operated on for supratentorial neoplasms were studied. Sixty-five had preoperative seizures and were treated with antiepileptic drugs (AEDs). Among the 63 patients without preoperative epileptic fits, 41 were given AEDs (either phenobarbital or phenytoin) as prophylactic treatment and 22 were not treated. The preoperative epilepsy course was considered with respect to tumour site and histological type. Early and late postoperative seizure occurrence was considered in the different groups of patients. The results suggest the usefulness of a short term preventive treatment with AEDs after surgery in patients without preoperative seizures. In patients with preoperative epilepsy, AEDs should be continued after surgery. However long-term AEDs treatment should not be recommended in patients without preoperative epilepsy. In fact, no significant difference in late seizure occurrence was found between preventively treated and untreated patients.

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Epilepsy Following Radical Removal of Parasagittal and Convexity Meningiomas

Cited by 10 publications

References 4 publications

Risk profile associated with convexity meningioma resection in the modern neurosurgical era

Risk profile associated with convexity meningioma resection in the modern neurosurgical era

Meningiomas and Epilepsy

Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours

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