Epilepsy diagnosis based on one unprovoked seizure and ≥60% risk. A systematic review of the etiologies

López, Salvador Vergara; Ramos-Jiménez, Christian; Reyes, Luis Adrián de la Cruz; Ruiz, Axel Kevin Galindo; Arriola, Luis Armando Baigts; Olivares, Juan Manuel Moncayo; Galindo, Enya Gabriela Aguirre; Pedroza, Iván Fabricio Pérez; San-Juan, Daniel

doi:10.1016/j.yebeh.2021.108392

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…For example, stroke and dementia, two leading causes of neurological deaths and DALYs, share both risk factors and protective factors 87 – 91 . Similarly, seizures occur commonly in multiple brain disorders, either as a result of brain insults or through shared mechanisms 92 . These crossovers present unique opportunities for shared preventive strategies and alignment of disease management, and interdisciplinary synergy — for example, digitization of services and national investment in workforce capacity — is required to optimize health system efficiency.…”

Section: Towards Improving Brain Healthmentioning

confidence: 99%

Global synergistic actions to improve brain health for human development

Owolabi,

Leonardi,

Bassetti

et al. 2023

Nat Rev Neurol

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The global burden of neurological disorders is substantial and increasing, especially in low-resource settings. The current increased global interest in brain health and its impact on population wellbeing and economic growth, highlighted in the World Health Organization’s new Intersectoral Global Action Plan on Epilepsy and other Neurological Disorders 2022–2031, presents an opportunity to rethink the delivery of neurological services. In this Perspective, we highlight the global burden of neurological disorders and propose pragmatic solutions to enhance neurological health, with an emphasis on building global synergies and fostering a ‘neurological revolution’ across four key pillars — surveillance, prevention, acute care and rehabilitation — termed the neurological quadrangle. Innovative strategies for achieving this transformation include the recognition and promotion of holistic, spiritual and planetary health. These strategies can be deployed through co-design and co-implementation to create equitable and inclusive access to services for the promotion, protection and recovery of neurological health in all human populations across the life course.

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Section: Towards Improving Brain Healthmentioning

confidence: 99%

Global synergistic actions to improve brain health for human development

Owolabi,

Leonardi,

Bassetti

et al. 2023

Nat Rev Neurol

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“…The onset of seizures after ICH is associated with poor functional outcomes and increased risk of death (6,7). The onset of seizures within the first days of ICH onset is also associated with a greater risk of subsequently developing epilepsy (recurrent spontaneous seizures) (8), which in turn carries an increased risk of long-term functional outcomes and cognitive deficits. The risk of dementia for example is multiplied by 2.5 when seizures develop any time after intracerebral (9).…”

Section: Introductionmentioning

confidence: 99%

Acute Seizures After Spontaneous Intracerebral Hemorrhage in Young Individuals: 11-Year Trends and Association With Mortality

Lekoubou,

Cohrs,

Dejuk

et al. 2024

Preprint

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BACKGROUND The rate of sICH is rising among young Americans. Trends in acute seizure (AS) incidence in this age group is largely unknown. Further, the association of AS with mortality has not been reported in this age group. We determine trends in AS among young individuals with sICH. METHODS The Merative MarketScan® Commercial Claims and Encounters database, for the years 2005 through 2015, served as the data source. This period was chosen as spontaneous ICH incidence increased among young individuals between 2005 and 2015. Our study population included patients aged 18 to 64 years with ICH identified using the International Classification of Diseases, Ninth and Tenth Revision (ICD-9/10) codes 430, 431, 432.0, 432.1, 432.9, I61, I61.0, I61.1, I61.2, I61.3, I61.4, I61.5, I61.6, I61.8, and I61.9, excluding those with a prior diagnosis of seizures (ICD-9/10 codes 345.x,780.3x, G40, G41, and R56.8). We computed yearly AS incidence, mortality (in patients with and without seizures), and analyzed trends. We applied a logistic regression model to determine the independent association of AS with mortality accounting for demographic and clinical variables. RESULTS AS incidence increased linearly between 2005 (incidence rate: 8.1%) and 2015 (incidence rate: 11.0%), which represents a 26% relative increase (P for trends <0.0001. In-hospital mortality rate was 14.3% among those who developed AS and 11.5% among those who did not. Between 2005 and 2015, overall, in-hospital mortality decreased from 13.0% to 9.7% among patients without AS but remained unchanged among those with AS. Patients who developed AS were 10% more likely to die than those who did not (OR: 1.10, 95% confidence interval: 1.02-1.18). CONCLUSIONS Between 2005 and 2015, AS incidence increased by nearly 26% among young Americans with sICH. In-patient mortality remained unchanged among those who developed seizures but declined among those who did not. The occurrence of AS was independently associated with a 10% higher risk of in-hospital death.

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