Epilepsy and vitamin D: a comprehensive review of current knowledge

Yazdi, Seyed Amir Miratashi; Abbasi, Moslem; Yazdi, Seyed Masoud Miratashi

doi:10.1515/revneuro-2016-0044

Cited by 21 publications

(15 citation statements)

References 161 publications

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“…Various associations have been reported between vitamin D status and brain diseases, such as epilepsy. 25-OH-vitamin D3 supplementation results in improved seizure control in patients with pharmaco-resistant epilepsy (Holló et al, 2012; Miratashi et al, 2017). In 2013, Zhao et al reported a correlation between 25-OH-vitamin D3 deficiency and the prevalence of Alzheimer’s and Parkinson’s diseases (Oudshoorn et al, 2008; Zhao et al, 2013).…”

Section: Vitamin D3 In Neurological Disordersmentioning

confidence: 99%

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System

Faye¹,

Poumeaud²,

Miressi³

et al. 2019

Front. Neurosci.

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In this review, we draw attention to the roles of calcitriol (1,25-dihydroxyvitamin D3) in the trophicity of the peripheral nervous system. Calcitriol has long been known to be crucial in phosphocalcium homeostasis. However, recent discoveries concerning its involvement in the immune system, anti-cancer defenses, and central nervous system development suggest a more pleiotropic role than previously thought. Several studies have highlighted the impact of calcitriol deficiency as a promoting factor of various central neurological diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease. Based on these findings and recent publications, a greater role for calcitriol may be envisioned in the peripheral nervous system. Indeed, calcitriol is involved in myelination, axonal homogeneity of peripheral nerves, and neuronal-cell differentiation. This may have useful clinical consequences, as calcitriol supplementation may be a simple means to avoid the onset and/or development of peripheral nervous-system disorders.

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Section: Vitamin D3 In Neurological Disordersmentioning

confidence: 99%

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System

Faye¹,

Poumeaud²,

Miressi³

et al. 2019

Front. Neurosci.

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“…The study of anticonvulsant medication influence on Vitamin D rate is extremely important, this fact being confirmed by a large number of foreign publications devoted to this issue [1][2][3][4][5]. For instance, Sharma А. et al in their article "A complication of valproate therapy and a thought beyond Vitamin D deficiency" suggested that a long-term use of Vitamin D supplements for 6 months in combination with Carnitine and discontinuation of Sodium Valproate promoted the recovery of patients with proximal myopathy [6].…”

Section: Introductionmentioning

confidence: 96%

Современный Взгляд На Проблему Влияния Противоэпилептических Препаратов На Статус Витамина D (Клинический Случай С Обзором Литературных Источников)

Povoroznyuk¹,

Dubetska²,

Zaverukha³

2021

PJS

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This article presents a clinical case of the antiepileptic drug effect on the Vitamin D rate (namely, the patient has been taking Sodium Valproate for a long time) and new data from the foreign publications on this problem. It is known that there is a list of drugs that adversely affect the Vitamin D metabolism. In particular, the drugs reducing the Vitamin D absorption include drugs for the treatment of epilepsy. Antiepileptic drugs are drugs of various origins that are used to prevent or reduce seizures, their corresponding conditions (loss or impairment of consciousness, behavioral and autonomic disorders, etc.), which are observed with recurrent seizures of various forms of epilepsy. The widespread use of these drugs in medical practice requires a detailed study of possible side effects of these drugs and their timely correction, as foreign sources indicate that antiepileptic drugs increase Vitamin D deficiency and worsen the symptoms of proximal myopathy, requiring mandatory medical correction; patients with epilepsy are deficient in vitamin D; сhronic Valproate therapy is associated with lower bone mineral density in young patients with epilepsy. This clinical case showed how a long-term use of Sodium Valproate led to the development of secondary systemic osteoporosis and Vitamin D deficiency, as evidenced by the results of laboratory and instrumental studies, and the discontinued antiepileptic drugs along with Vitamin D supplementation improved the general health of the patient and Vitamin D blood rates. Based on the systemic review and our own observations, it has been concluded that epilepsy patients taking antiepileptic drugs should be given Vitamin D supplements to prevent the development of osteoporosis and Vitamin D deficiency.

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“…Recently, hypovitaminosis D was also reported in children with epilepsy receiving anti-seizure medications (ASMs), especially enzyme-inducing ASMs (EIASMs) ( 11 – 13 ). EIASMs exert their effects on destructing VitD status via inducing cytochrome P450 ( 14 ). However, it still remains controversial over the effects of valproic acid (VPA) – a type of non-enzyme-inducing ASMs (NEIASMs), on the VitD levels.…”

Section: Introductionmentioning

confidence: 99%

Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

Dong

Guo

et al. 2022

Front. Nutr.

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ObjectiveTo compare the serum 25-OH-VitD levels, the major marker of vitamin D (VitD) status, between healthy children and children with epilepsy before initiation of and during anti-seizure medications (ASMs) treatment and to evaluate the potential influence factors on 25-OH-VitD levels. Another major aim was to assess the potential role of VitD supplementation.MethodsFor comparison, we finally enrolled and collected data from 6,338 healthy children presenting to Health Care Department and 648 children visiting primary care pediatricians with symptoms of epilepsy in Children’s Hospital of Nanjing Medical University from January 2019 to June 2021. The demographic and biochemical characteristics of each child were extracted from the hospital information system.ResultsSerum 25-OH-VitD levels in 648 children with epilepsy were significantly lower than those of 6,338 healthy children (P < 0.0001), and the percentage of VitD insufficiency and deficiency status in pediatric patients was 49.19%. Of note, the serum 25-OH-VitD levels in children with newly diagnosed epilepsy before receiving any ASMs treatment were also significantly lower than those in healthy controls. Interestingly, ASMs therapy, alone or in combination, did not consistently reduce baseline serum VitD levels in children with epilepsy. The lower serum VitD levels in pediatric patients than those in healthy children might be related to the disease itself, rather than the ASMs treatment. As expected, VitD supplementation substantially increased the serum 25-OH-VitD levels (P < 0.0001). More critically, children with epilepsy receiving VitD supplementation achieved good seizure control in our study.SignificanceIn this retrospective study, the childhood epilepsy before initiation of and during ASMs treatment decreased the serum 25-OH-VitD concentrations, suggesting a clear association between epileptic disease and the risk of VitD deficiency. ASMs coadministration and long-term valproic acid treatment did not worse VitD-deficiency status, but in the small group receiving VitD supplementation, there was a significant improvement in reduction of seizure frequency. Therefore, pediatric clinicians are urged to raise public awareness of epilepsy-associated VitD deficiency.

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Epilepsy and vitamin D: a comprehensive review of current knowledge

Cited by 21 publications

References 161 publications

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System

Современный Взгляд На Проблему Влияния Противоэпилептических Препаратов На Статус Витамина D (Клинический Случай С Обзором Литературных Источников)

Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

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