Epilepsy and the concentrations of plasma amino acids in humans

Huxtable, Ryan J.; Laird, Hugh E.; Lippincott, Shirley E.; Walson, Philip D.

doi:10.1016/0197-0186(83)90019-0

Cited by 38 publications

(14 citation statements)

References 17 publications

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“…The mean plasma taurine concentration for epileptic subjects from the study of Huxtable et al (1983) did not differ from the corresponding mean in the present study ( t = 1.21, p > 0.2). Their baseline control mean (following overnight fast) was some- what higher than ours (d = 2.33, p < 0.05; FisherBehrens test, Fisher and Yates, 1957).…”

Section: Discussioncontrasting

confidence: 75%

Antiepileptic Drugs and Plasma and Platelet Taurine in Epilepsy

1989

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Although older studies have reported elevated plasma taurine concentrations, more recent studies have reported the same or lower plasma taurine concentrations in epileptic than in control subjects. The present study determined plasma taurine concentrations in 114 epileptic and 99 control subjects. In addition, taurine concentrations in platelets, known to be rich in taurine, were assayed. Serum drug concentrations were also determined to detect possible effects on plasma or platelet taurine concentrations. The plasma and platelet taurine concentrations of epileptic subjects were significantly more variable than corresponding control data. Mean platelet taurine was significantly lower for epileptic patients than for controls. Analysis of variance (ANOVA) on data from epileptic patients revealed no significant association between platelet or plasma taurine concentrations and drug or seizure groups. However, t tests revealed a higher mean plasma taurine concentration for patients with primary generalized seizure disorders (group II) receiving valproate (VPA) (p less than 0.004). Utilizing serum drug concentrations, a significant negative correlation (rxy = -0.552) was found between log-converted platelet taurine and serum VPA concentrations (p less than 0.01) among group II patients. Results were interpreted as having potential value for less empiric drug use and as indicating that cellular rather than plasma studies will prove more informative in gaining an understanding of the idiopathic epilepsies.

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Section: Discussioncontrasting

confidence: 75%

Antiepileptic Drugs and Plasma and Platelet Taurine in Epilepsy

1989

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“…There exists an extensive literature linking taurine and seizure disorders (Van Gelder, 1972;Van Gelder and Courtois, 1972;Wheler et al, 1977;Haug and Nitsch, 1982;Huxtable et al, 1983; cf. also Van Gelder, this volume).…”

Section: Discussionmentioning

confidence: 99%

“…Neuroinhibitory amino acids, such as GABA, glycine and taurine, also have been identified as prominent contributing components in processes associated with seizure phenomena (Van Gelder, 1972;Ribak et al, 1979;Haug and Nitsch, 1982;Huxtable et al, 1983). The fact that physiological studies continue to provide evidence that these amino acids depress the firing rate of central neurons has supported the argument that these sUbstances may function to maintain a homeostatic level of neuronal excitability and under conditions of hyperexcitability serve as endogenous anticonvulsants (Barbeau et al, 1975;Phillis, 1978;Huxtable, 1981;Toth et al, 1983;Lehmann et al, 1984).…”

Section: Introductionmentioning

confidence: 93%

“…The role of neuroactive amino acids in seizure phenomena has been a subject of intensive study in the past (Morselli et al, 1981;Perry and Hansen, 1981;Huxtable et al, 1983). An additional impetus to this area of research followed the observation that exogenous excitatory amino acids, such as kainic acid, can produce in animals an electroencephalographic and neuropathological profile reminiscent of that found in human patients with temporal lobe epilepsy (Nadler et al, 1978;Pisa et al, 1980;Lothman and Collins, 1981;Sloviter and Damiano, 1981;French et al, 1982;Ben-Ari, 1985).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Excitotoxic Actions of Taurine in the Rat Hippocampus Studied in Vivo and in Vitro

French

Vezzani

Whetsell

et al. 1986

Advances in Experimental Medicine and Biology

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“…1,7) However, several lines of evidence implied that the taurine biosynthesis is inhibited in GES-treated rats. Thus, GES reduces the tissue taurine concentration not only in rats given taurine but also in rats fed a taurine-free diet Two groups of rats were kept on a taurine-free purified diet.…”

Section: Discussionmentioning

confidence: 99%