Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders

Milovanović, Miloš; Radivojević, Vlada; Radosavljev-Kircanski, Jelena; Grujičić, Roberto; Tošković, Oliver; Aleksić-Hil, Olivera; Pejovic-Milovancevic, Milica

doi:10.1016/j.yebeh.2018.12.011

Cited by 18 publications

(40 citation statements)

References 63 publications

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“…When only the children without a history of epilepsy were considered, 50% of these had epileptiform anomalies. Of these patients, 60% had abnormalities only during sleep, and 3.6% had epileptiform activity only in wakefulness, highlighting once again the fact that an EEG sleep is essential to detect SEAs [ 23 , 38 ].…”

Section: Seas In Non-epileptic Patients With Asdmentioning

confidence: 99%

Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications

et al. 2020

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A large body of literature reports the higher prevalence of epilepsy in subjects with Autism Spectrum Disorder (ASD) compared to the general population. Similarly, several studies report an increased rate of Subclinical Electroencephalographic Abnormalities (SEAs) in seizure-free patients with ASD rather than healthy controls, although with varying percentages. SEAs include both several epileptiform discharges and different non-epileptiform electroencephalographic abnormalities. They are more frequently associated with lower intellectual functioning, more serious dysfunctional behaviors, and they are often sign of severer forms of autism. However, SEAs clinical implications remain controversial, and they could represent an epiphenomenon of the neurochemical alterations of autism etiology. This paper provides an overview of the major research findings with two main purposes: to better delineate the state-of-the-art about EEG abnormalities in ASD and to find evidence for or against appropriateness of SEAs pharmacological treatment in ASD.

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Section: Seas In Non-epileptic Patients With Asdmentioning

confidence: 99%

Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications

et al. 2020

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“…Though this study suggests the role of connectivity in early development is associated with ASD risk, the ultimate diagnostic outcome was not available for infants in this study, so it is unclear whether connectivity has any predictive validity for autism-risk [47]. Recent work has focused upon EEG complexity as a marker of connectivity in ASD [48].…”

Section: Neurodevelopmental Disorders/autism Spectrum Disordermentioning

confidence: 94%

Overcoming traps and challenges in child and adolescent psychiatry

et al. 2021

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Appropriate healthcare and psychological support for children and adolescents is essential for the successful development and good mental health. Unfortunately, this is often a neglected element in the healthcare systems around the world. It is known that approximately half of all adult psychiatric disorders start under the age of 14 and that the prevalence of child and adolescent-onset psychiatric conditions is increasing. The real reason for this increase remains unclear but it demands our attention as does the care of affected children, adolescents and their families. Transitions between different age groups need to be made easily navigable for the patients and their families. Many challenges in child and adolescent psychiatry are present, especially in developing countries such as in Serbia. A possible solution for overcoming these challenges is uniting of child and adolescent professional societies from all over the world. These societies should work together to develop unified strategies for diagnosis, treatment and support of children affected by psychiatric conditions. By working closely with pediatricians, family physicians, psychologists, nurses and other professionals, child and adolescent psychiatry can use knowledge and skills to support practice while teaching other professionals how to optimize the utilization of child and adolescent psychiatry services

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“…Few studies have analyzed the association between IEDs and ASD. The studies of Tetsu [30] and Milovanovic [75], which do not support an association between ASD and IED, are recent studies that present statistical significance. Few studies have reported clinical relevance [30,75].…”

Section: Future Research Directions and Conclusionmentioning

confidence: 99%

“…This finding is very important since it does not associate IED with autism. Similarly, Milovanovic [75] noted that IEDs did not exert a significant effect on the core symptoms of autism according to assessments by the ADI-R.…”

Section: Interictal Epileptiform Dischargesmentioning

confidence: 99%

“…On the one hand, it is necessary to determine the type of discharges that are associated with a cognitive-behavioral deficit, which is associated with ASD. At the same time, clinicians must bear in mind that, at present, there are data that do support the existence of an association between IEDs and ASD or ADI-R domains [75], and these studies label it as an epiphenomenon [30].…”

Section: Interictal Epileptiform Dischargesmentioning

confidence: 99%

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Association between Interictal Epileptiform Discharges and Autistic Spectrum Disorder

Luz-Escamilla

Morales-González

2019

Brain Sciences

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It has been reported that bioelectric alterations in an electroencephalogram (EEG) may play an etiological role in neurodevelopmental disorders. The clinical impact of interictal epileptiform discharges (IEDs) in association with autistic spectrum disorder (ASD) is unknown. The Autism Diagnostic Interview-Revised (ADI-R) is one of the gold standards for the diagnosis of autistic spectrum disorder. Some studies have indicated high comorbidity of IED and ASD, while other studies have not supported an association between the central symptoms of autism and IED. This review examines the high comorbidity and clinical impact of IED; patients with epilepsy are excluded from the scope of this review. ASD can be disabling and is diagnosed at an average age of 5 years old, at which point the greatest neurological development has occurred. If an association between IED and ASD is identified, a clinical tool that entails an innocuous procedure could enable diagnosis in the first years of life. However, in the absence of reports that prove an association between IED and ASD, patients should not be subjected to expensive treatments, such as the administration of anticonvulsant therapies.

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Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders

Cited by 18 publications

References 63 publications

Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications

Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications

Overcoming traps and challenges in child and adolescent psychiatry

Association between Interictal Epileptiform Discharges and Autistic Spectrum Disorder

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