Epilepsy and intellectual disability: Does epilepsy increase the likelihood of co-morbid psychopathology?

Arshad, Saadia; Winterhalder, Robert; Underwood, Lisa; Kelesidi, Katerina; Chaplin, Eddie; Kravariti, Eugenia; Anagnostopoulos, Dimitrios; Bouras, Nick; McCarthy, Jane; Tsakanikos, Elias

doi:10.1016/j.ridd.2010.10.013

Cited by 34 publications

(28 citation statements)

References 20 publications

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“…In contrast to these results Arshad et al have discovered that the presence of epilepsy is not associated with an increased likelihood of co-morbid psychopathology, moreover personality and anxiety disorders are significantly lower in adults with intellectual disability and epilepsy. The investigators suggest the mood-stabilizing and other psychotropic effects of antiepileptic drugs and diagnostic overshadowing as a possible explanation of these findings [26] . Hermans et al have also confirmed a negative association of increased depressive symptoms with epilepsy in patients with intellectual disability; they have found no significant association of anxiety disorders [27] .…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly conclusions about the likelihood of comorbid psychopathology in these patients are contradictory. Some investigators have affirmed an increased risk of developing depression [25] , while others have found a decreased likelihood of depression and anxiety [26,27] . Therefore it remains unclear whether some factors are associated with psychopathology in patients with epilepsy and intellectual disability.…”

Section: Research Articlementioning

confidence: 99%

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Determinants of depression and anxiety in patients with refractory epilepsy and cognitive problems

Viteva

2014

Mol Cell Epilepsy

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Background and Purpose:Few studies of psychopathology in patients with cognitive problems and refractory epilepsy (RE) have been performed. We aimed to assess depression, anxiety, and their determining factors in Bulgarian patients with RE and cognitive problems.Methods: We conducted a study based on questionnaires designed for people with intellectual disability (stigma scale, Glasgow Depression Scale, Glasgow Anxiety Scale) and a purposeful interview on clinical and social factors of 64 patients with RE and cognitive problems.Results: We found depression in 40.63% and anxiety in 71.43% of study participants. Depression correlated with female gender P < 0.01 (2 = 6.48), seizure type P < 0.05 (2 = 7.68), seizure severity P < 0.05 (2 = 9.04), educational level P < 0.05 (2 = 3.86), and stigma P < 0.01 (2 = 12.57). Seizure severity, gender, stigma, and educational level proved to be predictors of depression on multivariate regression analysis P < 0.001 (F = 12.08). Anxiety correlated with seizure severity P < 0.05 (2 = 8.65), focal neurological deficit P < 0.05 (2 = 5.91), stigma P < 0.05 (2 = 7.01), and depression P < 0.05 (2 = 5.31). Seizure severity and focal neurological deficit were the only predictors of anxiety on multivariate regression analysis P < 0.001 (F = 6.35).Conclusions: We have affirmed frequent anxiety and depression in patients with RE and cognitive problems and their clinical, social, and demographic determinants. The results from our study prove the necessity of a multidisciplinary approach to these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Research Articlementioning

confidence: 99%

Determinants of depression and anxiety in patients with refractory epilepsy and cognitive problems

Viteva

2014

Mol Cell Epilepsy

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“…Epilepsy Prevalence estimates for epilepsy suggest the seizure disorder occurs in 20-40 % of people with ID, which is about 30 times higher than in the general population (Arshad et al 2011;. Presence of epilepsy appears to be affected by severity of ID, with one study suggesting that persons with severe ID were four times more likely to have epilepsy than those with mild or moderate ID (Arshad et al 2011).…”

Section: Psychosis and Schizophreniamentioning

confidence: 99%

“…Presence of epilepsy appears to be affected by severity of ID, with one study suggesting that persons with severe ID were four times more likely to have epilepsy than those with mild or moderate ID (Arshad et al 2011). Epilepsy in this population may also influence the development of psychopathology, although research on this topic is inconclusive at this time, and the manner in which this may occur remains speculative.…”

Section: Psychosis and Schizophreniamentioning

confidence: 99%

“…Epilepsy in this population may also influence the development of psychopathology, although research on this topic is inconclusive at this time, and the manner in which this may occur remains speculative. Suggested influential factors in the development of psychopathology among individuals with comorbid ID and epilepsy include the impact of seizures upon the well-being and quality of life of the individual affected, as well as the role of atypical neural development (Arshad et al 2011). Nevertheless, some researchers have found no increased risk of comorbid psychopathology among adults with ID and epilepsy, but rather decreased rates of schizophrenia, personality, and anxiety disorders among this group (Arshad et al 2011).…”

Section: Psychosis and Schizophreniamentioning

confidence: 99%

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Comorbid Conditions in Individuals with Intellectual Disabilities

Matson¹,

Matson²

2015

Autism and Child Psychopathology Series

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Behavioral disorder in people with an intellectual disability and epilepsy: A report of the Intellectual Disability Task Force of the Neuropsychiatric Commission of ILAE

et al. 2016

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SummaryThe management and needs of people with intellectual disability (ID) and epilepsy are well evidenced; less so, the comorbidity of behavioral disorder in this population. “Behavioral disorder” is defined as behaviors that are difficult or disruptive, including stereotypes, difficult or disruptive behavior, aggressive behavior toward other people, behaviors that lead to injury to self or others, and destruction of property. These have an important link to emotional disturbance. This report, produced by the Intellectual Disability Task Force of the Neuropsychiatric Commission of the ILAE, aims to provide a brief review of some key areas of concern regarding behavioral disorder among this population and proposes a range of research and clinical practice recommendations generated by task force members. The areas covered in this report were identified by experts in the field as being of specific relevance to the broad epilepsy community when considering behavioral disorder in persons with epilepsy and ID; they are not intended to be exhaustive. The practice recommendations are based on the authors’ review of the limited research in this field combined with their experience supporting this population. These points are not graded but can be seen as expert opinion guiding future research and clinical practice.

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Epilepsy and intellectual disability: Does epilepsy increase the likelihood of co-morbid psychopathology?

Cited by 34 publications

References 20 publications

Determinants of depression and anxiety in patients with refractory epilepsy and cognitive problems

Determinants of depression and anxiety in patients with refractory epilepsy and cognitive problems

Comorbid Conditions in Individuals with Intellectual Disabilities

Behavioral disorder in people with an intellectual disability and epilepsy: A report of the Intellectual Disability Task Force of the Neuropsychiatric Commission of ILAE

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