Epilepsy and EEG paroxysmal abnormalities in autism spectrum disorders

Parmeggiani, Antonia; Barcia, Giulia; Posar, Annio; Raimondi, Elena; Santucci, Margherita; Scaduto, Maria Cristina

doi:10.1016/j.braindev.2010.07.003

Cited by 109 publications

(83 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, approximately one third of individuals with ASD have epilepsy, and given the significant increase in autistic traits during epileptic activity, autistic traits would be expected to increase and decrease. Recent research suggests that there is an accumulative risk of epilepsy in adults with ASD, in which an increased prevalence of epilepsy to 58.5% was found in 345 adults with ASD (Parmeggiani et al, 2010). Therefore it must be questioned whether autistic traits are variable in adults with ASD, both with and without epilepsy.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study demonstrated this risk in the finding of a 24.9% prevalence of epilepsy in a sample of 345 inpatients with ASD, which increased to 58.5% in adults over 20 years of age (Parmeggiani et al, 2010). This increase contrasts with a decrease of rigid and repetitive behaviours in ASD including stereotypy, with chronological age (Esbensen et al, 2009).…”

Section: Cumulative Risk Of Epilepsymentioning

confidence: 99%

See 1 more Smart Citation

Autistic characteristics in adults with epilepsy

Wakeford

Hinvest

Ring

et al. 2014

Epilepsy & Behavior

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Cumulative Risk Of Epilepsymentioning

confidence: 99%

Autistic characteristics in adults with epilepsy

Wakeford

Hinvest

Ring

et al. 2014

Epilepsy & Behavior

View full text Add to dashboard Cite

“…Epileptic activity on EEG has been reported in 10%-72% of autism cases despite the absence of epileptic seizures (23,24). In fact, some investigators suggest routine EEG in the presence of an autism diagnosis (25). The current recommendation is not to request routine EEG in children with an autism spectrum disorder (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Otistik çocuklarda ne zaman EEG ve kraniyal MRG istiyoruz?

Saltık¹,

Başgül²

2014

Dusunen Adam

View full text Add to dashboard Cite

When do we recommend an EEG and cranial MRI evaluation for autistic children?Objective: This study has planned to investigate the role of electroencephalography (EEG) and cranial magnetic resonance imaging (cMRI) in the evaluation and diagnosis of neurological disorders combined with autism in children. Method: A total number of 121 autistic children ranging from 3 to 18 years of age and who had applied to our hospital's clinics between January 2010 and January 2011 were included. The sociodemographic properties, time of birth, birth history, weight at birth, age at onset of walking and language development were investigated. By means of a reevaluation of cMRI, sleep EEG and other examination findings, additional neurological diagnoses, if any were recorded. Children for whom, a cMRI/ EEG evaluation was carried out and for whom such an evaluation was not carried out was compared statistically as to certain risk factors separately for additional diagnoses and neurological disorders. In addition, the relationship between cMRI and EEG findings and additional neurological disorder was examined. Results: Autistic children (Male/Female: 92/76) aged 9.30±4.2 years have been diagnosed neurological disorder additionally with a percentage of 40%. The most common of these was the epileptic seizure as 33%. No data was obtained about an additional neurological disorder in 22% of cases who performed cMRI and in 34% of cases who performed EEG. Ratio of presence of a pathological finding in cMRI was high in patients with cerebral palsy, whereas it was not found to be meaningful in patients with epileptic seizures. Analyzing risk factors for neurological disease, birth history of perinatal problems and gait disorders were seen more frequently in patients who required cMRI as compared to those in patients who did not require cMRI. Gait age was older in patients who required cMRI (18±8 months) as compared to patients without cMRI (14±4 months). Conclusion: In our autistic children, cMRI and EEG examinations had been extensively used for the investigation of additional neurological disorders. Both cMRI and EEG examinations had been requested more frequent in the presence of perinatal problems. The other risk factors for additional neurological disorders were history of premature birth to request EEG and older age at onset of walking, walking problems to request cMRI. However with detailed clinic evaluation of autistic children and clarification for investigations criteria unnecessary EEG and cMRI should be avoided. Key words: Autism, childhood, cranial magnetic resonance imaging, EEG ÖZET Otistik çocuklarda ne zaman EEG ve kraniyal MRG istiyoruz?Amaç: Bu çalışma otistik çocuklarda görülebilecek nörolojik bozuklukları değerlendirme ve tanılamada elektroensefalografi (EEG), kraniyal manyetik rezonans görüntülemenin (kMRG) yeri ve tetkik amacıyla nasıl kullanıldığını araştırmak amacıyla planlandı. Yöntem: Hastanemiz kliniklerine Ocak 2010-Ocak 2011 yılları arasında, başvuran 3-18 yaşları arasında toplam 121 otistik çocuk çalış...

show abstract

“…Comorbid severe intellectual disability and motor deficits are associated with a high prevalence of seizures (42%), whereas the prevalence of seizures is only 6% to 8% in children with ASD without these problems or without an associated aetiological medical disorder. There are two peaks of incidence: between 0 and 5 years and between 10 and 15 years [30,32]. All types of epilepsy can be present: infantile spasms, atone attacks, myoclonic seizures, atypical absences, partial complex seizures and tonic-clonic seizures.…”

Section: Management Of Associated Medical Conditionsmentioning

confidence: 99%

“…Clinical diagnosis of epilepsy is often difficult because of similar manifestations of autism and epilepsy: staring, not reacting, blinking and motor stereotyped movements. On the other hand, autistic behavioural features are often seen in children with epileptic syndromes [32].…”

Section: Management Of Associated Medical Conditionsmentioning

confidence: 99%

Clinical practice

Olivié

2012

Eur J Pediatr

View full text Add to dashboard Cite

The prevalence of autism spectrum disorder (ASD) has increased considerably in the past decades. The primary care paediatrician plays an important role not only in the early recognition of ASD but also in its chronic management. Paediatricians need to be comfortable with the global care of children with ASD. The diagnostic assessment of children with ASD comprises the medical investigations to identify associated or underlying medical conditions. The most important associated conditions are seizures, feeding and gastrointestinal problems, sleep disturbances and dental abnormalities. The care of ASD patients is very demanding since along with the purely medical issues there are challenging behavioural and psychiatric conditions that need consideration and professional skills.

show abstract

Epilepsy and EEG paroxysmal abnormalities in autism spectrum disorders

Cited by 109 publications

References 26 publications

Autistic characteristics in adults with epilepsy

Autistic characteristics in adults with epilepsy

Otistik çocuklarda ne zaman EEG ve kraniyal MRG istiyoruz?

Clinical practice

Contact Info

Product

Resources

About