Epilepsy and eating disorders during pregnancy: Prevalence, complications and birth outcome

Kolstad, Eivind; Gilhus, Nils Erik; Veiby, Gyri; Reiter, Simone Frizell; Lossius, Morten I.; Bjørk, Marte Helene

doi:10.1016/j.seizure.2015.02.014

Cited by 14 publications

(13 citation statements)

References 26 publications

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“…Information on seizures during pregnancy and epilepsy subtype is now at our disposal and we will assess the effect of these variables on various offspring outcomes. Finally, we have found higher BMI in women with epilepsy before and during pregnancy (22,46) and are currently studying the frequency of and risk factors associated with overweight, obesity and weight gain during pregnancy in the cohort. These factors are of considerable interest, as they are known to increase pregnancy complications in women without epilepsy (57,58).…”

Section: The Impact Of Aed Exposure During Pregnancymentioning

confidence: 94%

“…High seizure frequency and previous anxiety and/or depression were the strongest risk factors (23). Women with epilepsy had a higher life-time prevalence of eating disorders, and more often had binge eating disorder during pregnancy than women without epilepsy (21,22).…”

Section: Maternal Risk Factors For Adverse Offspring Outcomementioning

confidence: 99%

“…We have investigated differences in the occurrence of low level of education (12 years or less), low income (199,999 NOK or less/yr, equal to 24 000 Euro), unemployment due to disability, single parenting, depression and/or anxiety from early pregnancy to 3 years after delivery, as well as eating disorders before and after pregnancy in in the MoBa cohort (21)(22)(23). Currently, we are investigating the impact of body weight increase during pregnancy on pregnancy complications in women with epilepsy, including overweight and obesity.…”

Section: Psychosocial Characteristics and Psychiatric Diseasementioning

confidence: 99%

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Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuropsychiatric

Bjørk¹,

Veiby²,

Spigset³

et al. 2014

Nor J Epidemiol

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Introduction: Antiepileptic drug (AED) teratogenicity is suspected to be the main cause of impaired development in children of women with epilepsy. However, many factors may confound the reported risks. The purpose of this review is to characterize the epilepsy cohort in the Norwegian Mother and Child Cohort Study (MoBa) and show how it can be used to detangle various risk factors for adverse outcome in children of mothers with epilepsy. Methods: MoBa is a large, long-term prospective, family-based cohort study. The database is linked to the Medical Birth Registry of Norway. The epilepsy cohort consists of mothers and their children representing more than 700 pregnancies. Blood samples were obtained from the mother during pregnancy and from the umbilical cord after delivery, and AED concentrations were measured. Validated screening tools determined the frequency of maternal confounding risk factors and adverse offspring outcomes. Risk estimates were reported as adjusted odds ratios with confidence intervals using the remaining MoBa cohort as a reference (n=107,597). Outcome in offspring of women with epilepsy without AED treatment in pregnancy and of fathers with epilepsy were used to separate the effect of epilepsy from the effect of in utero exposure to AEDs. Results: Socioeconomic and psychiatric risk factors for adverse offspring outcomes were more frequent in mothers with epilepsy. The frequency of adverse offspring outcome was increased at 6, 18 and 36 months for verbal, motor and social development. Children of women with epilepsy without AED treatment and of fathers with epilepsy were generally similar to children of women without epilepsy. Conclusion: Children of mothers with epilepsy are at risk of adverse outcomes. AED exposure emerges as the most important risk factor.

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Section: The Impact Of Aed Exposure During Pregnancymentioning

confidence: 94%

Section: Maternal Risk Factors For Adverse Offspring Outcomementioning

confidence: 99%

Section: Psychosocial Characteristics and Psychiatric Diseasementioning

confidence: 99%

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Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuropsychiatric

Bjørk¹,

Veiby²,

Spigset³

et al. 2014

Nor J Epidemiol

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“…Our main finding is an increased rate of eating disorder symptoms in an unselected and population‐based cohort of adolescents with epilepsy compared with a reference group. This is an important finding in a group that is known to be at risk of several psychiatric disorders . Better knowledge should increase awareness and lead to a better holistic treatment of epilepsy.…”

Section: Discussionmentioning

confidence: 91%

“…A population‐based study from England found an increase in risk of eating disorders among people with epilepsy in general . Pregnant women with epilepsy in Norway also more frequently reported an eating disorder than other women, especially binge eating disorder . The prevalence of eating disorders among adolescents continues to increase and is a predictor of negative outcome in terms of mental health disorders, substance abuse, deliberate self‐harm, and overweight or underweight .…”

mentioning

confidence: 99%

Young people with epilepsy have an increased risk of eating disorder and poor quality diet

et al. 2017

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SummaryObjectiveTo investigate whether adolescents with epilepsy are at increased risk of having self‐reported eating disorder symptoms and poor quality diet compared to young people from the general population.MethodsWe used data from the Health Profile for Children and Youth in Akershus Study, a cross‐sectional population‐based study based on a voluntary self‐reported questionnaire. There were 19,995 participants (response rate 85%) aged 13–19 years; 247 (1.2%) reported a lifetime diagnosis of epilepsy. Odds ratios (OR) and 95% confidence intervals (CI) for eating disorders, unhealthy diet, dieting, satisfaction with looks, and participation in sports were estimated by using a logistic regression model. All estimates were adjusted for single parents and poor family economy.ResultsChildren and adolescents with epilepsy had more eating disorders than their peers (OR 1.8, CI 1.0–3.0, p = 0.03). They were less satisfied with their own appearance (OR 0.7, CI 0.5–0.9, p = 0.02), and they eat more unhealthily (OR 1.7, CI 1.3–2.2, p = 0.001). Males with epilepsy were more likely to have been dieting (OR 3.1, CI 1.2–7.9, p = 0.02) and less satisfied with their own appearance (OR 0.4, CI 0.3–0.7, p < 0.001). Females with epilepsy were more likely to eat unhealthily (OR 1.7, CI 1.1–2.5, p = 0.01).SignificanceAdolescents with epilepsy are at increased risk of having eating disorder symptoms. They eat less healthily and are less satisfied with their looks. Health workers should be aware of this and bring diet and lifestyle into the dialogue with young people with epilepsy.

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Prevalence and related factors of eating disorders in pregnancy: a systematic review and meta-analysis

Öztürk

Ouyaba

2023

Arch Gynecol Obstet

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Epilepsy and eating disorders during pregnancy: Prevalence, complications and birth outcome

Abstract: Eating disorders in WWE contribute to the increased risk of pregnancy and delivery complications. Health personnel should be aware of eating disorders in WWE and refer them for treatment before pregnancy.

Cited by 14 publications

References 26 publications

Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuropsychiatric

Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuropsychiatric

Young people with epilepsy have an increased risk of eating disorder and poor quality diet

Prevalence and related factors of eating disorders in pregnancy: a systematic review and meta-analysis

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