Epilepsy Across the Spectrum

England, Mary Jane; Liverman, Catharyn T.; Schultz, Andrea M.; Strawbridge, Larisa M

doi:10.17226/13379

Cited by 82 publications

(2 citation statements)

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“…Although research over the past 10 years has informed us of social barriers to achieving optimal health generally among PWE ( 25 , 43 – 45 ), contextual factors such as insufficient insurance, housing insecurity, employment status, nutrition, and health literacy are important to consider ( 25 ). Further, because PWE with co-occurring cognitive impairment are more likely to be disabled ( 46 ), the SDH of the patient's caregivers should be taken into consideration, as the levels of financial, physical, and emotional burden can be immense ( 47 , 48 ).…”

Section: Context Of Sdh In Physical Activity and Exercise Among Pwementioning

confidence: 99%

Considering social determinants of health in the relationship between physical activity and exercise engagement and cognitive impairment among persons with epilepsy

Hansen

Allendorfer

2022

Front. Rehabilit. Sci.

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Many persons with epilepsy (PWE) are not as active or physically fit as compared to the general population. This lack of engagement in physical activity has been attributed to a number of factors, few of which take into consideration the social determinants of health (SDH). In this perspective, we highlight how SDH are considered in explaining lower levels of physical activity engagement among PWE, particularly for those experiencing cognitive impairment. We also discuss how these data can be applied in research to yield a greater impact on the quality of life among PWE. Consideration of SDH allows for increased understanding of how cognition can be both a determinant of physical activity and an outcome of environments conducive to physical activity in PWE.

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Section: Context Of Sdh In Physical Activity and Exercise Among Pwementioning

confidence: 99%

Considering social determinants of health in the relationship between physical activity and exercise engagement and cognitive impairment among persons with epilepsy

Hansen

Allendorfer

2022

Front. Rehabilit. Sci.

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“…Epilepsy is ranked the fourth most common and serious brain disorder in the world, with about 50 million of the world population affected. 1,2 A significant number of persons are diagnosed yearly with epilepsy globally. About 6 in 1000 people are affected in the developed countries, while about 10 in 1000 people are victims in the developing world.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant, Muscle Relaxant and In-Vitro Antioxidant Activities of Hydroethanol Leaf Extract of Costus afer Ker Gawl (Costaceae) in Mice

Murtala¹,

Akindele²,

Oreagba³

2020

TJNPR

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oxidative stress is a possible mechanism for the onset and development of epilepsy, while Menon et al. 9 demonstrated seizureinduced oxidative stress by reporting significant increase in the level of oxidative makers in epileptic patients. Antioxidant therapy in animal models, supported by clinical data, has been demonstrated to reduce oxidative stress and frequency of seizures. 10,11 Muscle spasm is a short painful muscular contraction which may be due to epilepsy. A number of conventional anti-epileptics, muscle relaxants and antioxidant drugs are currently available, but epilepsy is still poorly managed in about 20% of affected individuals. 12 Diseases caused by oxidative damage are still on the increase and the episodes of skeletal muscle spasm continue unabated. Hence, focus remains strong on indigenous plants which are promising sources of new drugs with better efficacy and safety profile relative to conventional agents, apart from the desirable prospect of developing standardized herbal remedies for CNS disorders. Costus afer Ker Grawl (Costaceae), Bush/Monkey sugar cane, is a perennial, herbaceous and rhizomatous plant found in Asia, Africa and Americas. 13-15 In west and tropical Africa, it grows well in moist or shady forest. 16,17 In Nigeria and other West African countries, C. afer is often planted in home gardens for medicinal purposes, with documentation of use in traditional medicine to treat diabetes, inflammation, joint pains, 16 measles, fever, malaria, etc. The rhizome decoction of another species (Costus dubius) is used to treat epilepsy. 18 This study was carried out to investigate the anticonvulsant, muscle relaxant and in-vitro antioxidant activities of the hydroethanol leaf extract of Costus afer in mice.

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