Epilepsy: A Spectrum Disorder

Sirven, Joseph I

doi:10.1101/cshperspect.a022848

Cited by 144 publications

(94 citation statements)

References 77 publications

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“…Regarding to the kind of seizures, there was no critical distinction between the two groups (60% in group 1 and 56% in group 2). This result was in agreement with the view of Joseph I, 2015 who mentioned that the kind and distribution of seizure precipitating factors are more or less similar in patients with different epilepsy subtypes [19].…”

Section: Discussionsupporting

confidence: 92%

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Triggering Factors for Breakthrough Seizures among Epileptic Patients. Cross Sectional Study in Epileptic Patients Attending Epilepsy Clinic Mansoura University Hospital, Egypt

Esmael

Gomaa

Saad

2019

INDJ

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Background:The prevalence of breakthrough seizures in persons with epilepsy is very high in developing countries. Consequently, patients and physicians should be aware of the possible factors that may cause breakthrough seizures. Objective: The aim of our study is to determine the possible factors that may be a precipitating cause for breakthrough seizures in patients with epilepsy. Methods: This cross-sectional study included 100 persons with epilepsy with idiopathic epilepsy receiving antiepileptic drugs (AEDs). They were divided into two groups. Group 1 included 50 persons with epilepsy with a history of recent breakthrough seizures. Group 2 included 50 persons with epilepsy who had not experienced any recent breakthrough seizures. Patients were subjected to a thorough questionnaire addressing precipitating factors. All participants were subjected to an electroencephalogram (EEG) and medication adherence assessment. Results: There was no significant differences between group 1 and group 2 regarding age, sex, age Esmael et al.; INDJ, 13(1): 1-10, 2019; Article no.INDJ.49366 2 of onset of epilepsy, occupation and marital status (P value range 0.5 -0.2). The patients in group 1 were found to have longer durations of epilepsy, lower adherence to AEDs (P = 0.001), more missed doses of AEDs (P = 0.0001), more side effects of AEDs (P = 0.0005), more sleep deprivation, lower level of AEDs (P = 0.0006), more frequently on AED polytherapy (P = 0.0002), and more flickering lights (P = 0.04) than the participants in group 2. In terms of the EEG, group 1 showed a higher percentage of abnormal EEGs and more frequent focal epileptiform discharges (P = 0.003). Also, pathological findings in MRI brain were associated with higher breakthrough seizures (P = 0.005). No significant difference was found in both group1 and group 2 regarding emotional stress (P = 0.55), substitution of brand AEDs by generic one (P = 0.83), concurrent illness (P = 1), or the use of non AEDs (P = 0.79). Original Research Article Conclusion:The precipitating factors of breakthrough seizures are multifactorial and it is very important to educate patients about these precipitating factors to achieve better control of epilepsy.

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Section: Discussionsupporting

confidence: 92%

“…Epilepsy is the fourth commonest neurological disorder after migraine, stroke, and Alzheimer's disease [2]. The etiology of seizures is multi factorial in affected individuals [3]. The overall prevalence of Epilepsy varies between 5 and 10 per 1000 [4].…”

Section: Introductionmentioning

confidence: 99%

Triggering Factors for Breakthrough Seizures among Epileptic Patients. Cross Sectional Study in Epileptic Patients Attending Epilepsy Clinic Mansoura University Hospital, Egypt

Esmael

Gomaa

Saad

2019

INDJ

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“…Epilepsy and disability are spectrum disorders (Sirven, ). The diagnoses interact with each other and appear differently in each child.…”

Section: Discussionmentioning

confidence: 99%

Parents’ experiences of videoconference as a tool for multidisciplinary information exchange for children with epilepsy and disability

Tschamper

Jakobsen

2019

Journal of Clinical Nursing

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Aims and objectives To explore the parents’ experiences with the multidisciplinary information exchange between different levels of the health‐ social and school services using videoconference. Background Children with epilepsy and disability are in need of long‐term multidisciplinary help and support. The information exchange between the child’s providers of support is challenging. Scant attention has been paid to the parents’ experiences of the information exchange. Design A qualitative study with a phenomenological–hermeneutical research approach. Method Children with epilepsy and disability had undergone a multidisciplinary assessment in a hospital in the tertiary health service followed by information exchange with each child’s local support service using videoconference. Five parents were interviewed individually within a week after the videoconference. The COREQ checklist was used in the process of reporting on the empirical material. Results The increased local participation in the videoconference and the knowledge translation between the professionals made the parents save time, as they did not have to explain the written reports to each provider locally. The impact of technology created an emotional distance to the person on the screen and the information exchanged that some enjoyed while others disliked. The quality of the relationships to the professionals seemed to be crucial for the parents to feel safe talking about sensitive tasks. Conclusion The parents prefer videoconference as a tool for information exchange to traditional face‐to‐face meetings as it enables discussions between professionals that might prevent treatment misunderstandings. They experience the method as time‐saving and patient‐centred. Relevance to clinical practice Professionals should be aware of the possible side effects of the impact of technology that might affect the interaction and the information exchange in a negative way. The findings are likely to be transferable beyond the current context.

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“…As per the International League Against Epilepsy, the occurrence of SE is either due to the failure in the mechanisms responsible for seizure termination or due to the initiation of mechanisms which leads to abnormal prolonged seizures (Trinka et al, ). SE leads to the long‐term effect, including neuronal death injury which is unavoidable as well single it can also decrease 10–25% reasoning and mental function of patients (Sirven, ). As per studies on clinical level, SE is a neurological disorder related to seizures which corresponds to imaging changes, like high T2WI signals, and degeneration of brain cell (Ribeiro et al, ; Wen, Yablonskiy, Salter, & Cross, ).…”

Section: Discussionmentioning

confidence: 99%

Protective role of sitagliptin against oxidative stress in a kainic acid‐induced status epilepticus in rats models via Nrf2/HO‐1 pathway

Wang

Zhu

2019

Drug Development Research

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Aim: Sitagliptin (Sita) is a dipeptidyl peptidase-4 inhibitor which has been approved as a curing medicine for Type 2 diabetes (T2D) and has also reported its neuroprotective and antioxidant activity. This article describes the therapeutic effects of Sita on induced rat model of SE by kainic acid (KA) and investigated the antioxidative pathway of sita. Methods: Sprague-Dawley male rats were used randomly divided in four groups: vehicle control, KA and Sita + KA in a 5 and 10 mg/kg doses respectively in further groups. SE in rats was induced by the administration of KA in Phosphate buffered saline (PBS) intraperitoneally (IP) in a dose of 15 mg/kg. Seizure intensity, oxidative stress parameters, TUNEL assay, histopathology, and Nrf2/HO-1 expressions were evaluated. Results: Increment in the latency in SE results in delaying the initiation of disease in the pretreated rats by Sita compared to induce group (KA) as well the percentage of occurrence of SE was decreased. The content of MDA elevates whereas the SOD production decreases on administering the KA at various time intervals. Sita shows protective action against the KAinduced SE by reducing the oxidative stress thus inhibiting the change in SOD and MDA was observed after KA administration prior SE onset. Based on the above results, the study explains possible molecular mechanism of Sita. Sita Pretreatment showed significant elevation in expression of Nrf2 and HO-1 proteins in hippocampus region of the brain. Conclusion: Above parameters defines the potential effect of Sita on brain injury occurred due to SE by anti-oxidative pathway.

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Epilepsy: A Spectrum Disorder

Cited by 144 publications

References 77 publications

Triggering Factors for Breakthrough Seizures among Epileptic Patients. Cross Sectional Study in Epileptic Patients Attending Epilepsy Clinic Mansoura University Hospital, Egypt

Triggering Factors for Breakthrough Seizures among Epileptic Patients. Cross Sectional Study in Epileptic Patients Attending Epilepsy Clinic Mansoura University Hospital, Egypt

Parents’ experiences of videoconference as a tool for multidisciplinary information exchange for children with epilepsy and disability

Protective role of sitagliptin against oxidative stress in a kainic acid‐induced status epilepticus in rats models via Nrf2/HO‐1 pathway

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