Epilepsy

Hoppe, Christian; Poepel, Annkathrin; Elger, Christian E.

doi:10.1001/archneur.64.11.1595

Cited by 404 publications

(142 citation statements)

References 16 publications

(24 reference statements)

Supporting

Mentioning

126

Contrasting

Order By: Relevance

“…In the seizure frequency scoring system of the Mayo Clinic [19,27], with a score from 0 to 12, controls would have been scored 0–2, whereas the active group in our study would have been ranked according to scores between 3 and 12. However, we are fully aware that in the case of active epilepsy, around 40% of seizures may be overlooked [28,29,30]. In the prospective survey chosen, we intended to raise figures not interfered by any unsuspected seizures in the control group.…”

Section: Discussionmentioning

confidence: 99%

General Surgery among Long-Term Residents with and without Active Epilepsy at the Kork Epilepsy Centre – A Prospective Comparative One-Year Survey

Steinhoff

Hartmann²,

Luy³

et al. 2010

Eur Neurol

View full text Add to dashboard Cite

Background/Aims: We prospectively assessed the frequency, type, severity and cause of treatment among the long-term residents of the Kork Epilepsy Centre in the year 2005. Methods: All long-term residents were exclusively referred to the general surgeon practicing on the campus. Patients were divided into 2 groups comprising 285 patients with active epilepsy and 53 controls who either never had epileptic seizures or have remained seizure free for at least 4 years. Results: The 1-year incidence of injuries was 54.2% among the active epilepsy group and 36.8% among controls (p = 0.0275). Several admissions due to differing reasons occurred in 16.8% of people with active epilepsy and in 7.5% of the controls (not significant). More than 2 admissions due to various reasons only occurred in patients with active epilepsy (range 3–9). Of all injuries, 41.3% were directly related to seizures. Among patients with active epilepsy, the 3 most frequent injuries were lacerations, bruises and fractures (29.6, 17.0 and 11.7%, respectively). Conclusion: According to this prospective study, active epilepsy turned out to be a significant risk factor for injuries under homogenous patient and observer conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

General Surgery among Long-Term Residents with and without Active Epilepsy at the Kork Epilepsy Centre – A Prospective Comparative One-Year Survey

Steinhoff

Hartmann²,

Luy³

et al. 2010

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…First, although all trials rely on changes in seizure frequency (the seizure diary) as an outcome parameter, unfortunately this is a most inaccurate measure. In a study by Bonn in which the patients’ diaries were compared to video electroencephalogram (EEG) telemetry, patients recorded only 44% of partial seizures, and even major seizures were missed, as were four out of five seizures at night 6. In a study using long‐term intracranial monitoring, 8 out of the 11 patients studied underestimated the real seizure rate by at least threefold 7.…”

Section: Today's Theories and Practices Which May Not Withstand The Tmentioning

confidence: 99%

The right and the wrong with epilepsy and her science

Shorvon

Schmidt²

2016

Epilepsia Open

View full text Add to dashboard Cite

SummaryThis is a commentary and an opinion paper attempting a critical reassessment of the methods and practices of epilepsy research as we see it. The enormous progress in the field of epilepsy in recent years is a cause of celebration. Advances have been made on most fronts, and the position of patients with epilepsy in society has greatly improved. However, there have also been culs‐de‐sac and dead ends of modern science and clinical practice which are also intriguing. It may be true that we can learn more from our mistakes than from our successes. In this opinion paper, we have listed some of the successes and some of the failures of past epilepsy practice, and also areas of current practice and theory which we feel are likely to prove mistaken. The underlying reasons for misdirected practices and theories include, in our view, the influence of fashion, bad science, and the bureaucracies of practice and academic medicine. As a result, some findings are far from objective. Recognition is the first step to remediation, and hopefully future research will minimize some of the pitfalls mentioned in this article and bring the “End of Epilepsy,” as defined and predicted by Oswei Temkin, closer than it is today.

show abstract

“…However, a problem in examining the impact of seizures is that most studies are based on self reporting. Self reporting may miss up to half of the seizures (Hoppe et al, 2007), especially when seizures involved the left temporal lobe (Kerling et al, 2006) and when loss of consciousness occurs (Detyniecki and Blumenfeld, 2014). In the rat model, occurrence of 69 or more secondary generalized tonic–clonic seizures resulted in neuronal loss in the temporal hilus of the dentate gyrus, CA1 and CA3 of the hippocampus (Kotloski et al, 2002).…”

Section: Structural Brain Damage Seizures or Ictal Slow Waves?mentioning

confidence: 99%

Is There a Relation between EEG-Slow Waves and Memory Dysfunction in Epilepsy? A Critical Appraisal

Höller

Trinka

2015

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Is there a relationship between peri-ictal slow waves, loss of consciousness, memory, and slow-wave sleep, in patients with different forms of epilepsy? We hypothesize that mechanisms, which result in peri-ictal slow-wave activity as detected by the electroencephalogram, could negatively affect memory processes. Slow waves (≤4 Hz) can be found in seizures with impairment of consciousness and also occur in focal seizures without impairment of consciousness but with inhibited access to memory functions. Peri-ictal slow waves are regarded as dysfunctional and are probably caused by mechanisms, which are essential to disturb the consolidation of memory entries in these patients. This is in strong contrast to physiological slow-wave activity during deep sleep, which is thought to group memory-consolidating fast oscillatory activity. In patients with epilepsy, slow waves may not only correlate with the peri-ictal clouding of consciousness, but could be the epiphenomenon of mechanisms, which interfere with normal brain function in a wider range. These mechanisms may have transient impacts on memory, such as temporary inhibition of memory systems, altered patterns of hippocampal–neocortical interactions during slow-wave sleep, or disturbed cross-frequency coupling of slow and fast oscillations. In addition, repeated tonic–clonic seizures over the years in uncontrolled chronic epilepsy may cause a progressive cognitive decline. This hypothesis can only be assessed in long-term prospective studies. These studies could disentangle the reversible short-term impacts of seizures, and the impacts of chronic uncontrolled seizures. Chronic uncontrolled seizures lead to irreversible memory impairment. By contrast, short-term impacts do not necessarily lead to a progressive cognitive decline but result in significantly impaired peri-ictal memory performance.

show abstract

Epilepsy

Cited by 404 publications

References 16 publications

General Surgery among Long-Term Residents with and without Active Epilepsy at the Kork Epilepsy Centre – A Prospective Comparative One-Year Survey

General Surgery among Long-Term Residents with and without Active Epilepsy at the Kork Epilepsy Centre – A Prospective Comparative One-Year Survey

The right and the wrong with epilepsy and her science

Is There a Relation between EEG-Slow Waves and Memory Dysfunction in Epilepsy? A Critical Appraisal

Contact Info

Product

Resources

About