Epilepsie und multiple Sklerose

Störring, Gustav

doi:10.1007/bf01813841

Cited by 12 publications

(2 citation statements)

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“…All of these studies report patients in advanced stages of MS, and this may account for the fact that all of them describe at least some degree of cortical atrophy. Leube's historically interesting paper from 1871 describes a patient with nocturnal dyspnea (Leube, 1871) with demyelinating lesions in both basal ganglia, and Störring reports large demyelinating lesions in both hemispheres of a patient with recurrent Jacksonian seizures (Störring, 1940). Unfortunately, both of these early, purely macroscopic, studies make no mention of the relation of the demyelinating lesions to the cerebral cortex.…”

Section: Pathological Studiesmentioning

confidence: 99%

Seizures in multiple sclerosis

et al. 2008

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SUMMARYSeizures have long been recognized to be part of the disease spectrum of multiple sclerosis (MS). While they occur in only a minority of patients with MS, epileptic seizures can have serious consequences. The treatment of MS can be epileptogenic, and antiepileptic treatment can conversely worsen the symptoms of MS. In this article we present an overview of the current literature on the epidemiology, clinical presentation, pathology, imaging, prognosis and treatment of epileptic seizures in MS.

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Section: Pathological Studiesmentioning

confidence: 99%

Seizures in multiple sclerosis

et al. 2008

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“…In 1940, Störring published "Epilepsie und multiple Sklerose." 16 In Störring's article (translated by author W.S. ), one of the cases (case 7) is Else B., a 30-year-old woman with MS, tonic seizures, and dizzy spells.…”

Section: Resultsmentioning

confidence: 99%

Harry Lee Parker and paroxysmal dysarthria and ataxia

et al. 2013

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Objective: To review descriptions of paroxysmal dysarthria and ataxia in multiple sclerosis (MS), with special attention given to Parker and his 1946 case series.Methods: Evaluation of original publications describing paroxysmal dysarthria and ataxia, bibliographic information, writings, and unpublished letters from the Mayo Clinic Historical Unit.Results: In 1940, Störring described a patient with MS with paroxysmal symptoms that included dizziness and trouble speaking, but also unilateral extremity weakness. In 1946, Parker published a series of 11 patients with paroxysmal dysarthria and ataxia. Six of these patients had MS, and he recognized this phenomenon as a manifestation of the disease. The term "paroxysmal dysarthria and ataxia" was first used in 1959 by Andermann and colleagues. Since that time, paroxysmal dysarthria and ataxia has become a well-recognized phenomenon in MS. More recent reports have suggested that the responsible lesion is located in the midbrain, near or involving the red nucleus. Paroxysmal motor and sensory phenomena are well-described complications of multiple sclerosis (MS). These stereotyped events are of sudden onset and brief duration, and can occur multiple times an hour. Paroxysmal symptoms that have been reported include diplopia, trigeminal neuralgia, facial paresthesia, pain, itching, tonic seizures, akinesia, and dysarthria and ataxia. [1][2][3] There is disagreement about who first described paroxysmal dysarthria and ataxia in MS, with some authors giving priority to Gustav Störring and others to Harry Lee Parker. Conclusions:2,4-7 Parker (figure) described patients with attacks of dysarthria and ataxia in 1946. Since then, paroxysmal dysarthria and ataxia has become a well-known phenomenon in MS, appearing in numerous neurology and MS textbooks. 1,2OBJECTIVE The objective of the study was to review the earliest descriptions of paroxysmal dysarthria and ataxia and its association with MS. Particular attention was given to Parker and his 1946 case series. The authors compared these early descriptions to subsequent case reports.METHODS The authors evaluated original publications describing paroxysmal dysarthria and ataxia in patients with MS, as well as bibliographic information, writings, and unpublished letters from the Mayo Clinic Historical Unit pertaining to Harry Lee Parker. The Harry Lee Parker Collection in the Mayo Clinic Historical Unit contains a quarter foot of material. PubMed was searched using the search term "paroxysmal dysarthria and ataxia" to identify more recent case reports and case series.

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