Épilepsie et santé de la reproduction : cohorte sénégalaise

Dadah, Samy Mohamed Lemine; Ndiaye, M.; Diop, Marième Soda; Seck, Lala Bouna; Diagne, N.S.; Ba, El Hadji Makhtar; Cissé, Ousmane; Gaye, Ndiaga Matar; Basse, Anna Modji; Sow, Adjaratou Dieynabou; Touré, Kamadore; Diop, Amadou Gallo

doi:10.1016/j.neurol.2014.05.002

Cited by 5 publications

(12 citation statements)

References 17 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seventeen articles were retained after screening the search results; these included 16 research articles [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] and one review paper [34]. One additional study was found via manual search [35].…”

Section: Resultsmentioning

confidence: 99%

“…There are currently many challenges and lacunae in the care of WWE in SSA, which reflects the poor understanding and neglect of the reproductive health needs of this population. There is a paucity of data on the subject of epilepsy and pregnancy in the African setting, with only two studies which investigated various reproductive health outcomes of WWE using a prospective approach [18,19]. One of these studies estimated the prevalence of convulsive epilepsy among pregnant women to be 3.33 per thousand [19].…”

Section: Resultsmentioning

confidence: 99%

“…In addition to these vulnerabilities, WWE who do get married are more likely to be divorced or abandoned by the partner after the birth of a child [22]. In contrast with these trends, more than half (74/120) of the WWE in a Senegalese study reported that epilepsy rather brought them closer to their partner [18]. However, a similar proportion of WWE in that study admitted being affected psychosocially by their condition.…”

Section: Quality Of Life Sexuality and Marriage Among Wwementioning

confidence: 91%

“…Upon assessing the prevalence of sexual disorders among Nigerian WWE, it was not different from the prevalence in age-matched controls without epilepsy, albeit a significantly higher Arizona Sexual Experience Scale (ASEX) scores indicative of poorer sexual functioning in WWE [25]. The Senegalese study found that 75% of WWE were sexually active, of which four out of five experienced reduced sexual drive which was attributed to AED (phenobarbital, carbamazepine and valproate) [18]. In Kenya, WWE were found to have reduced rates of reproductive fitness compared to the general population [26].…”

Section: Quality Of Life Sexuality and Marriage Among Wwementioning

confidence: 93%

“…Two studies examined contraceptive use among WWE in SSA [18,26]. In a Senegalese cohort, 62/120 (51.2%) WWE reported using contraception, with about one third of them (24/62) resorting to oral contraceptives [18].…”

Section: Pre-conception Period and Family Planningmentioning

confidence: 99%

See 4 more Smart Citations

Women with epilepsy in sub–Saharan Africa: A review of the reproductive health challenges and perspectives for management

Menon

Fodjo

Weckhuysen

et al. 2019

Seizure

View full text Add to dashboard Cite

Background: Epilepsy is one of the commonest neurological conditions affecting women of reproductive age. Epilepsy management during pregnancy is a clinical conundrum, requiring a balance between seizure control and risk minimization for the women with epilepsy (WWE) as well as for their fetuses. The objective of this comprehensive review is to explore the reproductive health challenges of WWE in sub-Saharan Africa (SSA) and ways to address them. Method: Relevant documentation published until June 2019 were retrieved via literature searches performed in PubMed and Google Scholar, as well as a manual search to identify grey literature. Results: WWE in SSA are generally more stigmatized and sexually exploited than women without epilepsy. Contraception use among WWE was reported only in Senegal (51%) and Kenya (14.7%). Only two prospective studies (one in Senegal and one in Nigeria) investigated pregnancy outcomes for a total of 97 WWE. The prevalence of convulsive epilepsy in pregnancy was estimated at 3.33 per 1000. Among pregnant WWE treated with first line anti-epileptic drugs, 16.2% had miscarriages, 41.9% premature births, and 4.1% had babies with malformations. Carbamazepine, which is frequently prescribed to pregnant WWE in SSA, still entails a 2.1-fold increased risk of congenital malformation. No reports were found concerning pre-conceptual counseling and post-natal outcomes in WWE in SSA. Conclusion: Our review underscores the need for contextualized evidence-based clinical guidelines and a collaborative approach to treat WWE in SSA. High risks of congenital malformations and drug interactions with first line AED warrant the provision of safer second line alternatives.

show abstract