Epilepsia partialis continua associated with nonketotic hyperglycemia: Clinical and biochemical profile of 21 patients

Singh, Brij Mohan Kumar; Strobos, Robert J.

doi:10.1002/ana.410080205

Cited by 155 publications

(104 citation statements)

References 25 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Hyperglycemia has been associated with symptoms of focal neurological dysfunction such as hemianopsias, hemiballism, hemichorea and choreo-athetosis [3][4][5][6] . Generally, patients had previous structural lesions in the areas related to these symptoms, perhaps making them more susceptible.…”

Section: Discussionmentioning

confidence: 99%

Complex partial seizures and aphasia as initial manifestations of non-ketotic hyperglycemia: case report

Batista

Silva

Ferraz

et al. 1998

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-We describe a case of non-ketotic hyperglycemia (NKH), heralded by complex partial seizures and aphasia of epileptic origin, besides versive and partial motor seizures. This clinical picture was accompanied by left fronto-temporal spikes in the EEG. The seizures were controlled by carbamazepine only after the control of the diabetes. A month later, carbamazepine was discontinued. The patient remained without seizures, with normal language, using only glybenclamide. Complex partial seizures, opposed to simple partial seizures, are rarely described in association to NKH. Epileptic activity localized over language regions can manifest as aphasia.KEY WORDS: aphasia, seizures, diabetes mellitus. Crises parciais complexas e afasia como manifestações iniciais de hiperglicemia não cetótica: relato de casoRESUMO -Descrevemos um caso de hiperglicemia não-cetótica (HNC) cujas manifestações iniciais foram crises parciais complexas e afasia de origem epiléptica, além de crises versivas e parcias motoras. Este quadro clínico foi acompanhado por atividade epileptiforme na região fronto-temporal esquerda ao eletrencefalograma. As crises epilépticas foram controladas com carbamazepina (CBZ) apenas após o controle do diabetes mellitus. Após um mês, a CBZ foi suspensa, permanecendo a paciente com linguagem normal, sem novas crises epilépticas, em uso apenas de glibenclamida. Crises parciais complexas, ao contrário de crises parciais simples, são raramente descritas como manifestação de HNC. Atividade epileptiforme nas regiões relacionadas a linguagem podem manifestar-se como afasia. PALAVRAS-CHAVE: epilepsia, crises epilépticas, diabetes mellitus, afasia.Non-ketotic hyperglycemia (NKH) is classically associated to simple partial seizures and partial motor status epilepticus (SE) and rarely to complex partial seizures (CPS) 1,2 . We present a case that was heralded by CPS and aphasia of epileptic origin, before systemic signs and symptoms of diabetic decompensation. CASE REPORTA 60 year old black woman, right-handed, was brought by relatives to the neurological emergency room because of altered behaviour for a week. She presented irritation and moments of staring, that seemed to "turn off", stopping domestic work. At other times, she stopped speaking, or forgot the names of her relatives and objects, answering only monosyllables. Besides these episodes, she looked completely well. The patient and relatives denied other neurologic and systemic complaints, including fever, polyphagia, polydipsia, polyuria and Escola Paulista

show abstract

Section: Discussionmentioning

confidence: 99%

Complex partial seizures and aphasia as initial manifestations of non-ketotic hyperglycemia: case report

Batista

Silva

Ferraz

et al. 1998

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Bu nöbet geçiren hasta grubununda ise 21 hastanın EPK geçirdiği izlenmiştir. [3] Fokal motor nöbetler ve EPK NKH hastalarının %25' inde gözlenebilir. [4] Aynı zamanda diyabetik hastada fokal nöbetler özelliklede EPK diyabetin ilk ortaya çıkış semptomu olabilir.…”

Section: Discussionunclassified

An Etiological Cause of Epilepsia Partialis Continua that Should Not be Forgotten: Hyperglycemia

Şen¹,

Özkan²,

Karaman³

2014

Epilepsi

View full text Add to dashboard Cite

126Halil Murat ŞEN, Adile ÖZKAN, Handan Işın ÖZIŞIK KARAMAN ÖzetEpilepsia parsiyalis kontinua genelde vücudun tek tarafına lokalize klonik jerklerin sattlerden, aylara dek sürebildiği tedaviye dirençli olabilen epileptik nöbettir. Yetişkin yaş grubunda etiyolojide beyin iskemik lezyonları, yer kaplayıcı lezyonları, enfeksiyonları mutlaka ekarte edilmelidir. Tanı konması daha kolay olan metabolik bozukluklar özellikle hiperosmolar nonketotik hiperglisemi etiyolojide unutulmamalıdır. Çünkü nonketotik hiperglisemi olgularının önemli bir kısmında epilepsia parsiyalis kontinua gelişmektedir hatta diyabet tanısı almamış bazı hastalarda diyabetin ilk bulgusu olarak ortaya çıkabilmektedir.Anahtar sözcükler: Epilepsi; hiperglisemi. SummaryEpilepsia partialis continua is generally epileptic seizures, resistant to treatment, consisting of clonic jerks localized to one side of the body that may last from hours to months. In the adult population, brain ischemic lesions, extensive lesions and infections should be ruled out of the etiology. The etiology of easier-to-diagnose metabolic disorders, especially hyperosmolar nonketotic hyperglycemia, should not be forgotten. This is because a significant number of nonketotic hyperglycemia cases develop epilepsia partialis continua; in fact in some patients without diabetes diagnosis, it may be the first finding of diabetes.

show abstract

“…In adults, it is related to vascular disease, tumor and inflammatory lesions involving the sensorimotor cortex 9,14,15 , non-ketotic hyperglicemia 16 , HIV 9 and liver insufficiency 17 , and in some cases, it is of idiopathic origin.…”

Section: Discussionmentioning

confidence: 99%

Epilepsia partialis continua (Koshevnikov): a preliminary case report

Castro-Costa

Vale

Leitão

et al. 2000

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-We report on the preliminary clinical and electrophysiological aspects of an in-patient possibly presenting epilepsia partialis continua (Koshevnikov). We discuss the different etiologies and emphasize on the possible idiopathic form in this case.KEY WORDS: epilepsia partialis continua, electrophysiology, symptoms, idiopathic form. Epilepsia parcial contínua (Kojevnikov): relato preliminar de um casoRESUMO -Relatamos os aspectos clínicos e eletrofisiológicos preliminares de um paciente hospitalizado que possivelmente apresenta crises de epilepsia parcial contínua (Kojevnikov). Discutimos as diferentes etiologias dessa condição e salientamos a possível forma idiopática, nesse caso.

show abstract

Epilepsia partialis continua associated with nonketotic hyperglycemia: Clinical and biochemical profile of 21 patients

Cited by 155 publications

References 25 publications

Complex partial seizures and aphasia as initial manifestations of non-ketotic hyperglycemia: case report

Complex partial seizures and aphasia as initial manifestations of non-ketotic hyperglycemia: case report

An Etiological Cause of Epilepsia Partialis Continua that Should Not be Forgotten: Hyperglycemia

Epilepsia partialis continua (Koshevnikov): a preliminary case report

Contact Info

Product

Resources

About