Epigenomic dynamics of early <i>Xenopus Embryos</i>

Zhou, Jeff Jiajing; Cho, Ken W.Y.

doi:10.1111/dgd.12813

Cited by 5 publications

(2 citation statements)

References 117 publications

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“…The animal zygote launches embryonic development from a totipotent chromatin state in a process that has been intensively studied using model invertebrate and vertebrate organisms (reviewed in Macrae et al 2023;Zhou and Cho, 2022;Ahmad and Henikoff, 2022;Gleason and Chen, 2022). Pluripotent cell lines derived from embryos (Thomson et al 1998) or reprogramed somatic cells (Takahashi and Yamanaka, 2006) provide technically favorable material for analyzing the gene expression, chromatin and metabolic states that drive stem cells to diverse differentiated derivatives (Rafalski et al 2012;Kinoshita and Smith, 2018;Omole et al 2018;Soldner and Jaenisch, 2018).…”

Section: Introductionmentioning

confidence: 99%

Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

Pang

DeLuca

Zhu

et al. 2023

Preprint

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Highly potent animal stem cells either self renew or launch complex differentiation programs, using mechanisms that are only partly understood. Drosophila female germline stem cells (GSC) perpetuate without change over evolutionary time and generate cystoblast daughters that develop into nurse cells and oocytes. Cystoblasts initiate differentiation by generating a transient syncytial state, the germline cyst, and by increasing pericentromeric H3K9me3 modification, actions likely to suppress transposable element activity. Relatively open GSC chromatin is further restricted by Polycomb repression of testis or somatic cell-expressed genes briefly active in early female germ cells. Subsequently, Neijre/CBP and Myc help upregulate growth and reprogram GSC metabolism by altering mitochondrial transmembrane transport, gluconeogenesis and other processes. In all these respects GSC differentiation resembles development of the totipotent zygote. We propose that the totipotent stem cells state was shaped by the need to resist transposon activity over evolutionary time scales.

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Section: Introductionmentioning

confidence: 99%

Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

Pang

DeLuca

Zhu

et al. 2023

Preprint

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“…In their mini‐review, Zhou and Cho (2022) describe recent progresses in epigenetic studies of early Xenopus development. In particular, they focused on dynamic changes in histone modifications in relation to two phases of zygotic genome activation (ZGA), called minor ZGA and major ZGA, before gastrulation.…”

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confidence: 99%

Versatile utilities of amphibians (Part 3)

et al. 2022

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Part 1 and Part 2 of the special issue "Versatile Utilities of Amphibians" were released in August and September, respectively, containing 11 articles in total. This current special issue, Part 3, includes five articles (one research article, three short research articles, and one minireview). In this preface, we briefly walk you through those five articles as well as a research article already published in the October issue. The two research articles are as follows. Yamaguchi et al. (2022) examined the process of red blood cell (RBC) transition during metamorphosis in Xenopus laevis and Rana ornativentris by observing larval and adult globin types. Using thyroid hormone (TH) or anemia induction, they showed that RBC transition is regulated through both TH-dependent and -independent processes. Iwasa et al. (2022) investigated proliferation and neurogenesis in the adult forebrain of the Japanese red-bellied newt Cynops pyrrhogaster. By EdU labeling of proliferative cells and immunohistochemistry analyses at multiple time points over 2 months, they revealed that EdU-positive cells were initially Sox2-positive (stem cell marker), but 2 months later became Sox2-negative and NeuN-positive (neuronal marker), suggesting that proliferative cells in the adult newt telencephalon differentiate into neuronal cells.

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Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

Pang,

DeLuca,

Zhu

et al. 2023

eLife

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Highly potent animal stem cells either self renew or launch complex differentiation programs, using mechanisms that are only partly understood. Drosophila female germline stem cells (GSC) perpetuate without change over evolutionary time and generate cystoblast daughters that develop into nurse cells and oocytes. Cystoblasts initiate differentiation by generating a transient syncytial state, the germline cyst, and by increasing pericentromeric H3K9me3 modification, actions likely to suppress transposable element activity. Relatively open GSC chromatin is further restricted by Polycomb repression of testis or somatic cell-expressed genes briefly active in early female germ cells. Subsequently, Neijre/CBP and Myc help upregulate growth and reprogram GSC metabolism by altering mitochondrial transmembrane transport, gluconeogenesis and other processes. In all these respects GSC differentiation resembles development of the totipotent zygote. We propose that the totipotent stem cell state was shaped by the need to resist transposon activity over evolutionary time scales.

show abstract

Epigenomic dynamics of early Xenopus Embryos

Cited by 5 publications

References 117 publications

Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

Versatile utilities of amphibians (Part 3)

Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

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