Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO
            <sub>2</sub>
            Air Pollution Exposure

Gruzieva, Olena; Xu, Cheng‐Jian; Breton, Carrie V.; Annesi‐Maesano, Isabella; Antó, Josep M.; Auffray, Charles; Ballereau, Stéphane; Bellander, Tom; Bousquet, Jean; Bustamante, Mariona; Charles, Marie‐Aline; Kluizenaar, Yvonne de; Dekker, Herman T. den; Duijts, Liesbeth; Felix, Janine F.; Gehring, Ulrike; Guxens, Mònica; Jaddoe, Vincent; Jankipersadsing, Soesma A; Merid, Simon Kebede; Kere, Juha; Kumar, Ashish; Lemonnier, Nathanaël; Lepeule, Johanna; Nystad, Wenche; Page, Christian M.; Panasevich, Sviatlana; Postma, Dirkje S.; Slama, Rémy; Sunyer, Jordi; Söderhäll, Cilla; Yao, Jin; London, Stephanie J.; Pershagen, Göran; Koppelman, Gerard H.; Melén, Erik

doi:10.1289/ehp36

Cited by 193 publications

(155 citation statements)

References 54 publications

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“…However, this investigation did not find evidence supporting differential DNA methylation associated to the evaluated factors (Rijlaarsdam et al 2016). In another important research, Gruzieva et al (2016) investigated the effect of maternal exposure during pregnancy to air pollution (NO 2 ), in DNA methylation of cord blood. The authors found epigenome-wide significant associations with LONP1, HIBADH and SLC25A28, genes involved in mitochondria function.…”

Section: Environmental Epigeneticsmentioning

confidence: 66%

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Epigenetics: from the past to the present

Villota-Salazar

Mendoza‐Mendoza

González-Prieto

2016

Frontiers in Life Science

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The definition of epigenetics is still under intense debate; however, its concept has evolved since it was originally introduced in 1939 by Conrad Hal Waddington as a way to reconcile antagonistic views between the school of preformationism and the school of epigenesis. The characterization of a large number of phenomena that diverge from the dogmas of classical genetics, and the discovery of the molecular mechanisms through which these phenomena occur, has given rise to a new area of study with important implications for biological sciences. Interactions between the environment and the DNA through modifications on the chromatin are not only responsible for the expression of a normal phenotype, these may be involved in the development of various pathologies. The epigenome, as the bridge between the genome and the phenotype, is no doubt one of the most interesting current ideas in genetics and is so revolutionary that it may change our present notions about inheritance and evolution. In this review, we made a compilation of the most important events in the history of epigenetics, its implications and some perspectives to the future.

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Section: Environmental Epigeneticsmentioning

confidence: 66%

“…The result for SLC25A28 was permanent in older children. They also observed differential methylation in genes CAT and TPO, related to antioxidant defense pathways (Gruzieva et al 2016).…”

Section: Environmental Epigeneticsmentioning

confidence: 94%

Epigenetics: from the past to the present

Villota-Salazar

Mendoza‐Mendoza

González-Prieto

2016

Frontiers in Life Science

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“…Environmental factors, which have been examined, include prenatal NO 2 air pollution exposure (10), prenatal exposure to maternal stress (9), postnatal exposure to air pollution (78), and obesity (79). These recent investigations identified differentially methylated regions (DMR) and related key epigenetic mechanisms altered in children.…”

Section: Inflammations Modulated By Epigenomic Regulationmentioning

confidence: 99%

“…These recent investigations identified differentially methylated regions (DMR) and related key epigenetic mechanisms altered in children. Candidate gene studies from DMR report oxidative stress, chronic inflammation, and antioxidant defense pathways in airways (10,(78)(79)(80).…”

Section: Inflammations Modulated By Epigenomic Regulationmentioning

confidence: 99%

“…Current paradigm of the asthma development involves intricate interactions between host genetics (8) and environmental stressors (9). Before and first few years of life is likely to be particularly critical period during which epigenetic (9,10), metabolomic (11), and transcriptomic (12)(13)(14) signaling mechanisms influence the robustness of the host's underlying immune susceptibility (15).…”

Section: Introductionmentioning

confidence: 99%

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Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

Choi

Song

Zhang

2017

Reviews on Environmental Health

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Abstract Asthma and other complex diseases results from a complex web of interactions involving inflammation, immunity, cell cycle, apoptosis, and metabolic perturbations across multiple organ systems. The extent to which various degrees of the age at onset, symptom severity, and the natural progression of the disease reflect multiple disease subtypes, influenced by unique process of development remains unknown. One of the most critical challenges to our understanding stems from incomplete understanding of the mechanisms. Within this review, we focus on the phenotypes of childhood allergic asthma as the basis to better understand the endotype for quantitative define subtypes of asthma. We highlight some of the known mechanistic pathways associated with the key hallmark events before the asthma onset. In particular, we examine how the recent advent of multiaxial -omics technologies and systems biology could help to clarify our current understanding of the pathway. We review how a large volume of molecular, genomic data generated by multiaxial technologies could be digested to identify cogent pathophysiologic molecular networks. We highlight some recent successes in application of these technologies within the context of other disease conditions for therapeutic interventions. We conclude by summarizing the research needs for the predictive value of preclinical biomarkers.

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Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy

Zhang,

Hu,

Talarico

et al. 2024

JAMA Netw Open

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ImportanceAir pollution is associated with structural brain changes, disruption of neurogenesis, and neurodevelopmental disorders. The association between prenatal exposure to ambient air pollution and risk of cerebral palsy (CP), which is the most common motor disability in childhood, has not been thoroughly investigated.ObjectiveTo evaluate the associations between prenatal residential exposure to ambient air pollution and risk of CP among children born at term gestation in a population cohort in Ontario, Canada.Design, Setting, and ParticipantsPopulation-based cohort study in Ontario, Canada using linked, province-wide health administrative databases. Participants were singleton full term births (≥37 gestational weeks) born in Ontario hospitals between April 1, 2002, and March 31, 2017. Data were analyzed from January to December 2022.ExposuresWeekly average concentrations of ambient fine particulate matter with a diameter 2.5 μm (PM2.5) or smaller, nitrogen dioxide (NO2), and ozone (O3) during pregnancy assigned by maternal residence reported at delivery from satellite-based estimates and ground-level monitoring data.Main outcome and measuresCP cases were ascertained by a single inpatient hospitalization diagnosis or at least 2 outpatient diagnoses for children from birth to age 18 years.ResultsThe present study included 1 587 935 mother-child pairs who reached term gestation, among whom 3170 (0.2%) children were diagnosed with CP. The study population had a mean (SD) maternal age of 30.1 (5.6) years and 811 745 infants (51.1%) were male. A per IQR increase (2.7 μg/m3) in prenatal ambient PM2.5 concentration was associated with a cumulative hazard ratio (CHR) of 1.12 (95% CI, 1.03-1.21) for CP. The CHR in male infants (1.14; 95% CI, 1.02-1.26) was higher compared with the CHR in female infants (1.08; 95% CI, 0.96-1.22). No specific window of susceptibility was found for prenatal PM2.5 exposure and CP in the study population. No associations or windows of susceptibility were found for prenatal NO2 or O3 exposure and CP risk.Conclusions and relevanceIn this large cohort study of singleton full term births in Canada, prenatal ambient PM2.5 exposure was associated with an increased risk of CP in offspring. Further studies are needed to explore this association and its potential biological pathways, which could advance the identification of environmental risk factors of CP in early life.

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Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO ₂ Air Pollution Exposure

Cited by 193 publications

References 54 publications

Epigenetics: from the past to the present

Epigenetics: from the past to the present

Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy

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Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO 2 Air Pollution Exposure

Cited by 193 publications

References 54 publications

Epigenetics: from the past to the present

Epigenetics: from the past to the present

Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy

Contact Info

Product

Resources

About

Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO ₂ Air Pollution Exposure