2020
DOI: 10.1186/s13148-019-0793-z
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Epigenome-wide association study of seizures in childhood and adolescence

Abstract: The occurrence of seizures in childhood is often associated with neurodevelopmental impairments and school underachievement. Common genetic variants associated with epilepsy have been identified and epigenetic mechanisms have also been suggested to play a role. In this study, we analyzed the association of genome-wide blood DNA methylation with the occurrence of seizures in~800 children from the Avon Longitudinal Study of Parents and Children, UK, at birth (cord blood), during childhood, and adolescence (perip… Show more

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Cited by 14 publications
(10 citation statements)
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References 57 publications
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“…Thus, the individual and gender differences noted by us can result in susceptibility to the development of various forms of neurological pathologies, including epilepsy. Furthermore, epigenetic factors (including DNA methylation) play a significant role in brain development and neuronal function and may contribute to the developmental neuropathologies, in particular epilepsy [11][12][13][14]74]. Indeed, we found a significant increase in the frequency of unmethylated UPS29 forms for patients with epilepsy, while there were no differences compared with controls among individuals with Parkinson's disease [72].…”
Section: Discussionmentioning
confidence: 99%
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“…Thus, the individual and gender differences noted by us can result in susceptibility to the development of various forms of neurological pathologies, including epilepsy. Furthermore, epigenetic factors (including DNA methylation) play a significant role in brain development and neuronal function and may contribute to the developmental neuropathologies, in particular epilepsy [11][12][13][14]74]. Indeed, we found a significant increase in the frequency of unmethylated UPS29 forms for patients with epilepsy, while there were no differences compared with controls among individuals with Parkinson's disease [72].…”
Section: Discussionmentioning
confidence: 99%
“…However, possible mutations in such different genes that can lead to epileptic seizures in most cases remain unclear [7][8][9]. The role of epigenetic modifications has been actively studied recently in the development of epilepsy [10][11][12][13][14].…”
Section: Introductionmentioning
confidence: 99%
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“…There are approximately 73 genes that are categorized as neurodevelopment-associated epilepsy genes [ 10 ]. Twenty-four genetic variants have been identified by two large genome-wide association studies that are linked with epilepsy [ 12 ]. The defect in the FMR1 gene is responsible for causing Fragile X Syndrome.…”
Section: Role Of Genes Genetics and Inheritancementioning
confidence: 99%
“…Childhood seizures can result in cellular and molecular changes that are potential risk factors for the development of epilepsy, in conjunction with a high association with neurodevelopmental conditions and learning and behavioral disabilities. 12 , 13 Over the years, genome-wide association epilepsy studies have focused on the identification of common genetic variants linked to epilepsy etiology in hopes of developing novel preventive strategies for therapeutic intervention. 14 , 15 However, epigenome-wide association studies (EWAS) have proven to be an additional factor to consider in the identification of high-risk gene loci in epilepsy.…”
Section: Commentarymentioning
confidence: 99%