Epigenome-wide association study of long-term psychosocial stress in older adults
Lauren A. Opsasnick,
Wei Zhao,
Lauren L. Schmitz
et al.
Abstract:Long-term psychosocial stress is strongly associated with negative physical and mental health outcomes, as well as adverse health behaviours; however, little is known about the role that stress plays on the epigenome. One proposed mechanism by which stress affects DNA methylation is through health behaviours. We conducted an epigenome-wide association study (EWAS) of cumulative psychosocial stress (
n
= 2,689) from the Health and Retirement Study (mean age = 70.4 years), assessing DNA me… Show more
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