Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS)

Xie, Ting; Gorenjak, Vesna; Stathopoulou, Maria G.; Dadé, Sébastien; Marouli, Eirini; Masson, Christine; Murray, Helena; Lamont, John; Fitzgerald, Peter; Deloukas, Panos; Visvikis‐Siest, Sophie

doi:10.3390/ijms20051014

Cited by 17 publications

(7 citation statements)

References 43 publications

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“…Changes in the environment, including temperature, light, and nutritional habits, trigger reversible epigenomic modification that can influence numerous physiological processes [28]. Epigenome-wide association studies (EWAS) provide information about associations between epigenomic perturbations and traits associated with human diseases [29]. EWAS try to evaluate the environmental impact on genetic regulation.…”

Section: Epigeneticsmentioning

confidence: 99%

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Epigenetics of Circadian Rhythm Disruption in Cardiovascular Diseases

Škrlec¹

2021

Cardiac Diseases - Novel Aspects of Cardiac Risk, Cardiorenal Pathology and Cardiac Interventions

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Circadian rhythm influences the regulation of homeostasis and physiological processes, and its disruption could lead to metabolic disorders and cardiovascular diseases (CVD). CVDs are still the dominant cause of death worldwide, which are related to numerous environmental and hereditary risk factors. Environmental and hereditary factors can clarify a small fraction of the CVD risk discrepancy. Epigenomics is a very bright strategy that will complement the knowledge of the genetic basis of CVDs. Epigenetic mechanisms allow cells to reply promptly to environmental changes and include DNA methylation, histone modification, and noncoding RNA alterations. According to research data, the circadian rhythm regulates many epigenetic regulators. The challenge is to understand how epigenetic events happen rhythmically in tissues that are involved in the development of CVDs. Epigenetic events are possibly reversible through their interface with environmental and nutritional factors, allowing innovative preventive and therapeutic strategies in cardiovascular diseases.

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Section: Epigeneticsmentioning

confidence: 99%

“…EWAS try to evaluate the environmental impact on genetic regulation. The epigenetic variations could explain missing parts of heritability of chronic diseases that have not yet been determined by genome-wide association studies [29].…”

Section: Epigeneticsmentioning

confidence: 99%

Epigenetics of Circadian Rhythm Disruption in Cardiovascular Diseases

Škrlec¹

2021

Cardiac Diseases - Novel Aspects of Cardiac Risk, Cardiorenal Pathology and Cardiac Interventions

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“…Levels of blood lipids, including high‐density lipoprotein (HDL) and low‐density lipoprotein (LDL) cholesterol, TAGs, total cholesterol, and lipoprotein subfractions, have been associated with DNA methylation status (Braun et al, 2017; Dekkers et al, 2016; Frazier‐Wood et al, 2014; Gomez‐Alonso et al, 2021; Hedman et al, 2017; Irvin et al, 2014; Nuotio et al, 2020; Pfeiffer et al, 2015; Xie et al, 2019). A recent large‐scale epigenome‐wide association study (EWAS) ( N = 16,265) found that hundreds of CpGs were associated with HDL, LDL, and TAGs in either trans‐ethnic or ethnic‐specific meta‐analyses (Jhun et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

The lipidomic correlates of epigenetic aging across the adult lifespan: A population‐based study

et al. 2023

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Lipid signaling is involved in longevity regulation, but which specific lipid molecular species affect human biological aging remains largely unknown. We investigated the relation between complex lipids and DNA methylation‐based metrics of biological aging among 4181 participants (mean age 55.1 years (range 30.0–95.0)) from the Rhineland Study, an ongoing population‐based cohort study in Bonn, Germany. The absolute concentration of 14 lipid classes, covering 964 molecular species and 267 fatty acid composites, was measured by Metabolon Complex Lipid Panel. DNA methylation‐based metrics of biological aging (AgeAccelPheno and AgeAccelGrim) were calculated based on published algorithms. Epigenome‐wide association analyses (EWAS) of biological aging‐associated lipids and pathway analysis were performed to gain biological insights into the mechanisms underlying the effects of lipidomics on biological aging. We found that higher levels of molecular species belonging to neutral lipids, phosphatidylethanolamines, phosphatidylinositols, and dihydroceramides were associated with faster biological aging, whereas higher levels of lysophosphatidylcholine, hexosylceramide, and lactosylceramide species were associated with slower biological aging. Ceramide, phosphatidylcholine, and lysophosphatidylethanolamine species with odd‐numbered fatty acid tail lengths were associated with slower biological aging, whereas those with even‐numbered chain lengths were associated with faster biological aging. EWAS combined with functional pathway analysis revealed several complex lipids associated with biological aging as important regulators of known longevity and aging‐related pathways.

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“…One of the most studied epigenetic mechanisms is DNA methylation, which plays an important role in normal development, chromatin organization and gene expression [3]. Several studies have indicated that DNA methylation is associated with cardiovascular risk factors such as body mass index (BMI) [4][5][6][7], gestational diabetes (GDM) [8], type 2 diabetes (T2D) [9][10][11][12][13], lipid levels [14,15], hypertension [16,17], smoking [18][19][20][21][22] and alcohol intake [23][24][25], suggesting that cardiometabolic diseases have an epigenetic component.…”

Section: Introductionmentioning

confidence: 99%

Cohort profile: Epigenetics in Pregnancy (EPIPREG) – population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes

et al. 2021

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Pregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother’s and child’s health. Epigenetics in Pregnancy (EPIPREG) is a population-based sample with the aim to study associations between DNA-methylation in pregnancy and cardiometabolic traits in South Asian and European pregnant women and their offspring. This cohort profile paper aims to present our sample with genetic and epigenetic data and invite researchers with similar cohorts to collaborative projects, such as replication of ours or their results and meta-analysis. In EPIPREG we have quantified epigenome-wide DNA methylation in maternal peripheral blood leukocytes in gestational week 28±1 in Europeans (n = 312) and South Asians (n = 168) that participated in the population-based cohort STORK Groruddalen, in Norway. DNA methylation was measured with Infinium MethylationEPIC BeadChip (850k sites), with technical validation of four CpG sites using bisulphite pyrosequencing in a subset (n = 30). The sample is well characterized with few missing data on e.g. genotype, universal screening for gestational diabetes, objectively measured physical activity, bioelectrical impedance, anthropometrics, biochemical measurements, and a biobank with maternal serum and plasma, urine, placenta tissue. In the offspring, we have repeated ultrasounds during pregnancy, cord blood, and anthropometrics up to 4 years of age. We have quantified DNA methylation in peripheral blood leukocytes in nearly all eligible women from the STORK Groruddalen study, to minimize the risk of selection bias. Genetic principal components distinctly separated Europeans and South Asian women, which fully corresponded with the self-reported ethnicity. Technical validation of 4 CpG sites from the methylation bead chip showed good agreement with bisulfite pyrosequencing. We plan to study associations between DNA methylation and cardiometabolic traits and outcomes.

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Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS)

Cited by 17 publications

References 43 publications

Epigenetics of Circadian Rhythm Disruption in Cardiovascular Diseases

Epigenetics of Circadian Rhythm Disruption in Cardiovascular Diseases

The lipidomic correlates of epigenetic aging across the adult lifespan: A population‐based study

Cohort profile: Epigenetics in Pregnancy (EPIPREG) – population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes

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