Epigenome – A mediator for host-microbiome crosstalk

Peery, Robert C.; Pammi, Mohan; Claud, Erika C.

doi:10.1016/j.semperi.2021.151455

Cited by 9 publications

(6 citation statements)

References 93 publications

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“…Clostridium is the most frequent genus of Firmicutes, while Bacteroides and Prevotella are the most frequent genera of Bacteroidetes ( Rinninella et al, 2019 ). Nevertheless, a large diversity of genera, such as Pseudomonas , Streptococcus , Fusobacterium , Veillonella , Haemophilus , Neisseria , Porphyromonas , Collinsella , Faecalibacterium , Eubacterium , Ruminococcus , Peptococcus , Peptostreptococcus , Lactobacillus , Streptomyces , and Bifidobacterium , has been reported in the gut microbiota ( Sheng et al, 2019 ; Peery et al, 2021 ). Aruguman et al (2011) analyzed 33 samples from European individuals using multidimensional cluster and principal component analyses.…”

Section: Microbiotamentioning

confidence: 99%

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Microbiota composition and its impact on DNA methylation in colorectal cancer

Gutierrez-Angulo,

Ayala-Madrigal,

Moreno-Ortiz

et al. 2023

Front. Genet.

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Colorectal cancer is a complex disease resulting from the interaction of genetics, epigenetics, and environmental factors. DNA methylation is frequently found in tumor suppressor genes to promote cancer development. Several factors are associated with changes in the DNA methylation pattern, and recently, the gastrointestinal microbiota could be associated with this epigenetic change. The predominant phyla in gut microbiota are Firmicutes and Bacteroidetes; however, an enrichment of Bacteroides fragilis, Fusobacterium nucleatum, and Streptococcus bovis, among others, has been reported in colorectal cancer, although the composition could be influenced by several factors, including diet, age, sex, and cancer stage. Fusobacterium nucleatum, a gram-negative anaerobic bacillus, is mainly associated with colorectal cancer patients positive for the CpG island methylator phenotype, although hypermethylation in genes such as MLH1, CDKN2A, MTSS1, RBM38, PKD1, PTPRT, and EYA4 has also been described. Moreover, Hungatella hathewayi, a gram-positive, rod-shaped bacterium, is related to hypermethylation in SOX11, THBD, SFRP2, GATA5, ESR1, EYA4, CDX2, and APC genes. The underlying epigenetic mechanism is unclear, although it could be implicated in the regulation of DNA methyltransferases, enzymes that catalyze the transfer of a methyl group on cytosine of CpG sites. Since DNA methylation is a reversible event, changes in gut microbiota could modulate the gene expression through DNA methylation and improve the colorectal cancer prognosis.

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Section: Microbiotamentioning

confidence: 99%

“…Inflammation, production of mutagenic biomolecules, and, recently, a dysregulation of epigenetic mechanisms have been described as possible mechanisms of microbiota-induced colorectal carcinogenesis ( Dahmus et al, 2018 ; Peery et al, 2021 ).…”

Section: Microbiota and Colorectal Cancermentioning

confidence: 99%

Microbiota composition and its impact on DNA methylation in colorectal cancer

Gutierrez-Angulo,

Ayala-Madrigal,

Moreno-Ortiz

et al. 2023

Front. Genet.

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“…Moreover, the recent correlation between microbiota composition and host epigenome suggests that the enrichment for certain microbial species could modulate unique gene expression signatures [ 8 ]. The epigenome is a dynamic player in host-microbiota crosstalk functional in precision medicine [ 108 ]. Should this fascinating hypothesis be confirmed, the control of epigenetic substrate levels produced by microbial species could represent a new avenue for clinical approaches with pre, pro or post-biotic supplementation to regulate epigenetic enzymes in the gut.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility—It Is Time to Consider the Triad

Fabozzi

Rebuzzini

Cimadomo

et al. 2022

Cells

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The gut microbiota (GM) is a complex and dynamic population of microorganisms living in the human gastrointestinal tract that play an important role in human health and diseases. Recent evidence suggests a strong direct or indirect correlation between GM and both male and female fertility: on the one hand, GM is involved in the regulation of sex hormone levels and in the preservation of the blood–testis barrier integrity; on the other hand, a dysbiotic GM is linked to the onset of pro-inflammatory conditions such as endometriosis or PCOS, which are often associated with infertility. Exposure to endocrine-disrupting chemicals (EDCs) is one of the main causes of GM dysbiosis, with important consequences to the host health and potential transgenerational effects. This perspective article aims to show that the negative effects of EDCs on reproduction are in part due to a dysbiotic GM. We will highlight (i) the link between GM and male and female fertility; (ii) the mechanisms of interaction between EDCs and GM; and (iii) the importance of the maternal–fetal GM axis for offspring growth and development.

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“…DNA methylation is believed to play an essential role in the regulation of gene expression, thereby determining cellular phenotype and behavior without altering the DNA sequence itself 21,22 . Within the context of IBD, DNA methylation has gained particular interest due to its dynamic interaction with the environment and suggested epigenetic-microbial crosstalk [23][24][25] . A number of recent studies demonstrated differential DNA methylation profiles associated with the presence of CD and/or specific CD-phenotypes 26,27 in peripheral blood leukocytes (PBL) [28][29][30] , intestinal mucosa 31 and specific cell-types thereof 32,33 .…”

Section: Introductionmentioning

confidence: 99%

Peripheral blood DNA methylation signatures predict response to vedolizumab and ustekinumab in adult patients with Crohn’s disease: The EPIC-CD study

Joustra,

Li Yim,

Henneman

et al. 2024

Preprint

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Biological therapeutics are now widely used in Crohn′s disease (CD), with evidence of efficacy from randomized trials and real-world experience. Primary non-response is a common, poorly understood problem. We assessed blood methylation as a predictor of response to vedolizumab (VDZ, anti-a4b7 integrin) or ustekinumab (USTE, anti-IL-12/23p40). We report a two-center, prospective cohort study in which we profiled the peripheral blood DNA methylome of 184 adult male and female CD patients prior to and during treatment with VDZ or USTE in a discovery (n=126) and an external validation cohort (n=58). We defined epigenetic biomarkers that were stable over time and associated with combined clinical and endoscopic response to VDZ or USTE with an area under curve (AUC) of 0.87 and 0.89, respectively. We validated these models in an external cohort yielding an AUC of 0.75 for both VDZ and USTE. These data will now be prospectively tested in a multicenter randomized clinical trial.

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Epigenome – A mediator for host-microbiome crosstalk

Cited by 9 publications

References 93 publications

Microbiota composition and its impact on DNA methylation in colorectal cancer

Microbiota composition and its impact on DNA methylation in colorectal cancer

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility—It Is Time to Consider the Triad

Peripheral blood DNA methylation signatures predict response to vedolizumab and ustekinumab in adult patients with Crohn’s disease: The EPIC-CD study

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