Epigenetics: The epicenter of the hypoxic response

Watson, Jenny; Watson, Chris; McCann, Amanda; Baugh, John

doi:10.4161/epi.5.4.11684

Cited by 149 publications

(132 citation statements)

References 30 publications

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“…In fact, low oxygen concentration has been found to correlate with more aggressive tumor behavior often resulting in poorer prognosis at least via the upregulation of hypoxia-inducible factors (HIFs) and other related oncogenic proteins through DNA demethylation or epigenetic regulation. 59 Current technologies, such as immunocytochemistry (ICC), liquid chromatography-mass spectrometry (LC-MS) and DNA-sequencing strategies can provide either a distribution or quantitative information of specific epigenetic modification, but none is capable of elucidating the dynamic transition process or recording the ongoing epigenetic aberrations. 60 Our work clearly shows that cells cultured under hypoxic conditions has distinct demethylation ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy

et al. 2013

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“…Conversely, other neurons lose completely their functions and interconnections. Current evidences suggest that perinatal asphyxia can alter gene expression, inducing epigenetic changes in DNA methylation, histone modifications and modifying the rate of noncoding RNA synthesis (10); in addition, the response to asphyxia depends on genetic and epigenetic key factors, integrated each other (11,12). Therapeutic hypothermia (TH), a brain cooling technique, usually maintained over 72 hours after the hypoxic-ischemic event, has gained consensus for the treatment of perinatal asphyxia and HIE, reducing the mortality rate and long-term neurodevelopmental disabilities at 12-24 months of age (13,14).…”

Section: Introductionmentioning

confidence: 99%

Urinary gas chromatography mass spectrometry metabolomics in asphyxiated newborns undergoing hypothermia: from the birth to the first month of life

Noto¹,

Pomero²,

Mussap³

et al. 2016

Ann. Transl. Med.

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Background: Perinatal asphyxia is a severe clinical condition affecting around four million newborns worldwide.It consists of an impaired gas exchange leading to three biochemical components: hypoxemia, hypercapnia and metabolic acidosis. Methods:The aim of this longitudinal experimental study was to identify the urine metabolome of newborns with perinatal asphyxia and to follow changes in urine metabolic profile over time. Twelve babies with perinatal asphyxia were included in this study; three babies died on the eighth day of life. Total-body cooling for 72 hours was carried out in all the newborns. Urine samples were collected in each baby at birth, after 48 hours during hypothermia, after the end of the therapeutic treatment (72 hours), after 1 week of life, and finally after 1 month of life. Urine metabolome at birth was considered the reference against which to compare metabolic profiles in subsequent samples. Quantitative metabolic profiling in urine samples was measured by gas chromatography mass spectrometry (GC-MS). The statistical approach was conducted by using the multivariate analysis by means of principal component analysis (PCA) and orthogonal partial least square discriminant analysis (OPLS-DA). Pathway analysis was also performed. Results:The most important metabolites depicting each time collection point were identified and compared each other. At birth before starting therapeutic hypothermia (TH), urine metabolic profiles of the three babies died after 7 days of life were closely comparable each other and significantly different from those in survivors. Conclusions:In conclusion, a plethora of data have been extracted by comparing the urine metabolome at birth with those observed at each time point collection. The modifications over time in metabolites composition and concentration, mainly originated from the depletion of cellular energy and homeostasis, seems to constitute a fingerprint of perinatal asphyxia.

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“…hypoxia is associated with epigenetic alterations in gene expression, 57 raises the possibility that transient exposure to hypoxia may alter anoikis-associated signaling in an epigenetic manner. By definition, cellular alterations occurring by an epigenetic switch must be heritable, persisting in the absence of the initial stimulatory event.…”

confidence: 99%

Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis

Whelan

Reginato²

2011

Cell Cycle

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Epigenetics: The epicenter of the hypoxic response

Cited by 149 publications

References 30 publications

Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy

Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy

Urinary gas chromatography mass spectrometry metabolomics in asphyxiated newborns undergoing hypothermia: from the birth to the first month of life

Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis

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