Epigenetics: Stress and disease

Perez‐Polo, J. Regino

doi:10.1016/j.ijdevneu.2017.08.002

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…They have been shown to affect several aspects of brain development by influencing the epigenetic modification of genes that play a role in this process [45]. In fact, the dysregulation of the brain epigenome by environmental factors during embryonic development can cause "fetal programming" with lasting effects on brain functioning and has been linked to many neurological disorders including mental health disorders [18,[46][47][48].…”

Section: The Role Of Key Methyl-donor Micronutrients and Epigenetic M...mentioning

confidence: 99%

Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet

Bekdash

2024

IJMS

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The relationship between nutrition and brain health is intricate. Studies suggest that nutrients during early life impact not only human physiology but also mental health. Although the exact molecular mechanisms that depict this relationship remain unclear, there are indications that environmental factors such as eating, lifestyle habits, stress, and physical activity, influence our genes and modulate their function by epigenetic mechanisms to shape mental health outcomes. Epigenetic mechanisms act as crucial link between genes and environmental influences, proving that non-genetic factors could have enduring effects on the epigenome and influence health trajectories. We review studies that demonstrated an epigenetic mechanism of action of nutrition on mental health, focusing on the role of specific micronutrients during critical stages of brain development. The methyl-donor micronutrients of the one-carbon metabolism, such as choline, betaine, methionine, folic acid, VitB6 and VitB12 play critical roles in various physiological processes, including DNA and histone methylation. These micronutrients have been shown to alter gene function and susceptibility to diseases including mental health and metabolic disorders. Understanding how micronutrients influence metabolic genes in humans can lead to the implementation of early nutritional interventions to reduce the risk of developing metabolic and mental health disorders later in life.

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Section: The Role Of Key Methyl-donor Micronutrients and Epigenetic M...mentioning

confidence: 99%

Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet

Bekdash

2024

IJMS

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Chronic Fatigue Stress and Sudden Death

Zhu¹,

Han²

2020

Sudden Death

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Stress refers to a series of neuroendocrine reactions, such as sympathetic nerve excitation and pituitary-adrenal cortex secretion increase, which occur when the body is stimulated by various stressors, and the changes of various functions and metabolism caused by these reactions. Chronic fatigue stress is a fatigue state caused by long-term physical and psychological stress. When the stress reaches a certain intensity or the individual is not well-tolerated, the body stability is impaired, resulting in various pathophysiological reactions leading to various diseases, such as stress hyperglycemia, stress cardiomyopathy, stress arrhythmia, stress ulcer hemorrhagic shock, or even stress ulcer hemorrhagic shock. Eventually lead to sudden death and other adverse events.

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Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection

Bekdash

2023

IJMS

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Methyl donors such as choline, betaine, folic acid, methionine, and vitamins B6 and B12 are critical players in the one-carbon metabolism and have neuroprotective functions. The one-carbon metabolism comprises a series of interconnected chemical pathways that are important for normal cellular functions. Among these pathways are those of the methionine and folate cycles, which contribute to the formation of S-adenosylmethionine (SAM). SAM is the universal methyl donor of methylation reactions such as histone and DNA methylation, two epigenetic mechanisms that regulate gene expression and play roles in human health and disease. Epigenetic mechanisms have been considered a bridge between the effects of environmental factors, such as nutrition, and phenotype. Studies in human and animal models have indicated the importance of the optimal levels of methyl donors on brain health and behavior across the lifespan. Imbalances in the levels of these micronutrients during critical periods of brain development have been linked to epigenetic alterations in the expression of genes that regulate normal brain function. We present studies that support the link between imbalances in the levels of methyl donors, epigenetic alterations, and stress-related disorders. Appropriate levels of these micronutrients should then be monitored at all stages of development for a healthier brain.

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Epigenetics: Stress and disease

Cited by 3 publications

References 14 publications

Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet

Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet

Chronic Fatigue Stress and Sudden Death

Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection

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