Epigenetics of paediatric acute myeloid leukaemia

Jones, Luke; McCarthy, Peter; Bond, Jonathan

doi:10.1111/bjh.16361

Cited by 12 publications

(10 citation statements)

References 114 publications

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“…Knocking out the BMI1 gene inhibits the cloning and sphere formation ability of CSCs ( 105 ). Studies have shown that abnormal levels of the histone demethylases lysine demethylase 6A (KDM6A) and KDM6B are associated with pediatric acute myeloid leukemia (AML) ( 106 ). Moreover, modification of histone proteins (H3K9ac, H3K27ac, H4K16ac, etc. )…”

Section: Ptm and Epigenetic Modification Regulate Cancer Stem Cellsmentioning

confidence: 99%

Phase separation in epigenetics and cancer stem cells

Xiao

Wu²,

Chen³

et al. 2022

Front. Oncol.

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Accumulating evidence indicates that liquid–liquid phase separation (LLPS) is the basis of the formation of membrane-less compartments in cells. This biomolecular condensate represented by phase separation may influence epigenetics in cancer stem cells (CSCs), a small subpopulation of cancer cells responding to the initiation, maintenance, metastasis, and therapy resistance of cancer. Understanding the underlying biophysical principles and the specific characteristics of biocondensates would provide insights into the precise blocking of potential tumor targets, thereby fundamentally curbing tumor occurrence, recurrence and metastasis. In this review, we summarized the key phenomenon and experimental detection of phase separation and the possibility of regulating the stemness of CSCs through phase separation. We believe that the mechanism of phase separation in CSCs will open up new avenues for the mystery of tumor formation, and modulating phase separation will be a great strategy for CSC-targeted tumor therapy.

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Section: Ptm and Epigenetic Modification Regulate Cancer Stem Cellsmentioning

confidence: 99%

Phase separation in epigenetics and cancer stem cells

Xiao

Wu²,

Chen³

et al. 2022

Front. Oncol.

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“…Multiple epigenetic modifications regulate the transition from hematopoietic stem cells to lineage differentiation and maturation at the transcription level, including DNA methylation, histone modifications, and non-coding RNAs. Epigenetic dysfunction is common in most cancers, and extensive studies have also focused on the mechanisms of epigenetic dysregulation in AML, though AML has few mutations compared to other cancer types ( 5 , 8 ). The current advances of epigenetic modifications in AML are briefly summarized below ( Table 1 ).…”

Section: Epigenetic Regulation and Dysregulation In Adult And Pediatr...mentioning

confidence: 99%

Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia

Wen

Jin

et al. 2022

Front. Pediatr.

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Acute myeloid leukemia (AML) is a hematological malignancy resulting from the genetic alterations and epigenetic dysregulations of the hematopoietic progenitor cells. One-third of children with AML remain at risk of relapse even though outcomes have improved in recent decades. Epigenetic dysregulations have been identified to play a significant role during myeloid leukemogenesis. In contrast to genetic changes, epigenetic modifications are typically reversible, opening the door to the development of epigenetic targeted therapy. In this review, we provide an overview of the landscape of epigenetic alterations and describe the current progress that has been made in epigenetic targeted therapy, and pay close attention to the potential value of epigenetic abnormalities in the precision and combinational therapy of pediatric AML.

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“…Studies have shown that abnormal expression of histone codes is an important feature of cancer tissues and is related to the heterogeneity of cancer cells ( 31 , 32 ). Studies have shown that abnormal levels of the histone demethylases, KDM6A and KDM6B, are associated with pediatric acute myeloid leukemia (AML) ( 33 ). Moreover, modification of the histone proteins H3K9ac, H3K27ac, and H4K16ac plays an important role in the progression and prognosis of head and neck squamous cell carcinoma (HNSCC) ( 34 ).…”

Section: Research Hotspots Of Cancer Epigeneticsmentioning

confidence: 99%

Therapeutic Targeting of Cancer: Epigenetic Homeostasis

Guo

et al. 2021

Front. Oncol.

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A large number of studies have revealed that epigenetics plays an important role in cancer development. However, the currently-developed epigenetic drugs cannot achieve a stable curative effect. Thus, it may be necessary to redefine the role of epigenetics in cancer development. It has been shown that embryonic development and tumor development share significant similarities in terms of biological behavior and molecular expression patterns, and epigenetics may be the link between them. Cell differentiation is likely a manifestation of epigenetic homeostasis at the cellular level. In this article, we introduced the importance of epigenetic homeostasis in cancer development and analyzed the shortcomings of current epigenetic treatment regimens. Understanding the dynamic process of epigenetic homeostasis in organ development can help us characterize cancer according to its differentiation stages, explore new targets for cancer treatment, and improve the clinical prognosis of patients with cancer.

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Epigenetics of paediatric acute myeloid leukaemia

Abstract: a schematic of the associate proteins interacting with core components RING1A/B and PCGF1-6 to form non-canonical PRC1 complexes. (B) PRC2 core subunits and the associate proteins required to form PRC2.1 and PRC2.2 complexes.

Cited by 12 publications

References 114 publications

Phase separation in epigenetics and cancer stem cells

Phase separation in epigenetics and cancer stem cells

Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia

Therapeutic Targeting of Cancer: Epigenetic Homeostasis

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