Epigenetics of Mammalian Gamete and Embryo Development

Rodríguez-Osorio, Nélida; Doğan, Şule; Memili, Erdoğan

doi:10.1002/9781119949930.ch1

Cited by 3 publications

(4 citation statements)

References 159 publications

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“…Methylation marks are just one mechanism that modulates phenotypes. Other regulators of gene expression include histone modifications, chromatin remodelling, and RNA-mediated silencing [ 16 ]. Histones, proteins in chromatin, undergo various posttranslational modifications that affect their interactions with nuclear proteins and DNA.…”

Section: Introductionmentioning

confidence: 99%

Stress-induced epigenetic effects driven by maternal lactation in dairy cattle: a comethylation network approach

López-Catalina,

Reverter,

Alexandre

et al. 2024

Epigenetics

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Epigenetic marks do not follow the Mendelian laws of inheritance. The environment can alter the epigenotype of an individual when exposed to different external stressors. In lactating cows, the first stages of gestation overlap with the lactation peak, creating a negative energy balance that is difficult to overcome with diet. This negative energy balance could affect early embryo development that must compete with the mammary tissue for nutrients. We hypothesize that the methylation profiles of calves born to nonlactating heifers are different from those of calves born to lactating cows. We found 50,277 differentially methylated cytosines and 2,281 differentially methylated regions between these two groups of animals. A comethylation network was constructed to study the correlation between the phenotypes of the mothers and the epigenome of the calves, revealing 265 regions associated with the phenotypes. Our study revealed the presence of DMCs and DMRs in calves gestated by heifers and lactating cows, which were linked to the dam’s lactation and the calves’ ICAP and milk EBV. Gene-specific analysis highlighted associations with vasculature and organ morphogenesis and cell communication and signalling. These finding support the hypothesis that calves gestated by nonlactating mothers have a different methylation profile than those gestated by lactating cows.

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Section: Introductionmentioning

confidence: 99%

Stress-induced epigenetic effects driven by maternal lactation in dairy cattle: a comethylation network approach

López-Catalina,

Reverter,

Alexandre

et al. 2024

Epigenetics

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“…For example, soon after fertilization, in paternal origin chromosomes, the protamines are replaced by histones that present high levels of acetylation and low levels of methylation ( Messerschmidt et al., 2014 ; Urrego et al., 2014 ). On the other hand, the maternal genome undergoes few changes, maintaining the same pattern of lysine acetylation and arginine methylation in H3 and H4 ( Rodriguez-Osorio et al., 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Erasing gametes to write blastocysts: metabolism as the new player in epigenetic reprogramming

et al. 2020

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Understanding preimplantation embryonic development is crucial for the improvement of assisted reproductive technologies and animal production. To achieve this goal, it is important to consider that gametes and embryos are highly susceptible to environmental changes. Beyond the metabolic adaptation, the dynamic status imposed during follicular growth and early embryogenesis may create marks that will guide the molecular regulation during prenatal development, and consequently impact the offspring phenotype. In this context, metaboloepigenetics has gained attention, as it investigates the crosstalk between metabolism and molecular control, i.e., how substrates generated by metabolic pathways may also act as players of epigenetic modifications. In this review, we present the main metabolic and epigenetic events of pre-implantation development, and how these systems connect to open possibilities for targeted manipulation of reproductive technologies and animal production systems.

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“…Although by the 8-to 16-cell stage the DNA methylation level of the cloned embryo has decreased considerably, the pattern of methylation is heterogeneous in the blastomeres. The trophectoderm and ICM cells of cloned blastocysts have similar methylation levels, unlike the differential methylation observed in embryos produced by fertilization[210].…”

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confidence: 98%

“…By the blastocyst stage, the DNA methylation level in the trophectoderm cells is markedly lower compared to cells of the inner cell mass ICM. At the peri-gastrulation stage de novo DNA methylation is completed throughout the entire embryo[210].…”

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confidence: 99%