Epigenetics of Livestock Health, Production, and Breeding

Ibeagha‐Awemu, Eveline M.; Khatib, Hasan

doi:10.1016/b978-0-323-91909-8.00041-4

Cited by 2 publications

(3 citation statements)

References 332 publications

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“…Some studies showed that many miRNAs in cattle, such as miR-23b, miR-24, miR-146a, and miR-181a have been differentially expressed in response to, and have been suggested as potential biomarkers for monitoring the severity of heat stress (Neethirajan, 2022b). Similarly, in pigs, miR-122, miR-199a-3p, miR-23a, and miR-27b have been found to be differentially expressed in response to heat stress and have been suggested as potential biomarkers for monitoring the stress response in these animals (Ibeagha-Awemu & Khatib, 2023). Some other miRNAs implicated in livestock health and welfare include miR-143 and miR-145, which have been found to play a role in adipogenesis and muscle development in pigs, and miR-155, which has been shown to play a role in immune function and stress response in various livestock species (Ibeagha-Awemu & Khatib, 2023).…”

Section: The Mirnas That Are Related To Health and Welfare In Livestockmentioning

confidence: 99%

“…Similarly, in pigs, miR-122, miR-199a-3p, miR-23a, and miR-27b have been found to be differentially expressed in response to heat stress and have been suggested as potential biomarkers for monitoring the stress response in these animals (Ibeagha-Awemu & Khatib, 2023). Some other miRNAs implicated in livestock health and welfare include miR-143 and miR-145, which have been found to play a role in adipogenesis and muscle development in pigs, and miR-155, which has been shown to play a role in immune function and stress response in various livestock species (Ibeagha-Awemu & Khatib, 2023). Therefore, it is concluded that miRNAs are a promising avenue for exploring the molecular mechanisms underlying various health and welfare outcomes in livestock and could potentially serve as valuable biomarkers for monitoring animal health and welfare to develop practical applications for their use in livestock management.…”

Section: The Mirnas That Are Related To Health and Welfare In Livestockmentioning

confidence: 99%

“…Some studies have shown that specific miRNAs are differentially expressed in the mammary gland of high-and low-milk-yielding cows, and that these differences are at least partially attributed to genetic factors (Billa et al, 2021;Cui et al, 2020;Hosseini et al, 2022;Hu et al, 2022). Similarly, miRNA expression profiles in pigs' liver, muscle, and adipose tissue have been found to vary among breeds with different growth rates and body composition (Gley et al, 2019;Ibeagha-Awemu & Khatib, 2023).…”

Section: The Mirnas and Genetic Background In Livestockmentioning

confidence: 99%

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MicroRNAs as potential biomarkers for heat stress in livestock

Safdar¹,

Özaslan

2023

ZBS

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Heat stress is a major concern for livestock production, as it can result in reduced animal welfare, decreased production efficiency, and even mortality. MicroRNAs (miRNAs) are small non-coding RNA molecules that play a critical role in regulating gene expression and have been proposed as potential biomarkers for heat stress in livestock. Several studies have investigated the expression of miRNAs in response to heat stress in various livestock species, including cattle, pigs, and chickens. These studies have identified specific miRNAs differentially expressed in response to heat stress, suggesting they could serve as biomarkers for this condition. For example, in cattle, miR-21, miR-23a, miR-24, miR-27a, miR-30a-5p, and miR-126 have been shown to be upregulated in response to heat stress, while miR-122, miR-127, miR-148a, miR-195, and miR-335 were downregulated. In pigs, were downregulated in response to heat stress. In chickens, were upregulated, while miR-let-7f and miR-181a were downregulated. In conclusion, miRNAs have shown promise as potential biomarkers for heat stress. In addition, it is necessary to validate these findings and explore their potential use in developing diagnostic tools for monitoring heat stress in livestock.

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Section: The Mirnas That Are Related To Health and Welfare In Livestockmentioning

confidence: 99%

Section: The Mirnas That Are Related To Health and Welfare In Livestockmentioning

confidence: 99%

Section: The Mirnas and Genetic Background In Livestockmentioning

confidence: 99%

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MicroRNAs as potential biomarkers for heat stress in livestock

Safdar¹,

Özaslan

2023

ZBS

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DNA methylation haplotype block signatures responding to Staphylococcus aureus subclinical mastitis and association with production and health traits

Wang,

Bissonnette,

Laterrière

et al. 2024

BMC Biol

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Background DNA methylation has been documented to play vital roles in diseases and biological processes. In bovine, little is known about the regulatory roles of DNA methylation alterations on production and health traits, including mastitis. Results Here, we employed whole-genome DNA methylation sequencing to profile the DNA methylation patterns of milk somatic cells from sixteen cows with naturally occurring Staphylococcus aureus (S. aureus) subclinical mastitis and ten healthy control cows. We observed abundant DNA methylation alterations, including 3,356,456 differentially methylated cytosines and 153,783 differential methylation haplotype blocks (dMHBs). The DNA methylation in regulatory regions, including promoters, first exons and first introns, showed global significant negative correlations with gene expression status. We identified 6435 dMHBs located in the regulatory regions of differentially expressed genes and significantly correlated with their corresponding genes, revealing their potential effects on transcriptional activities. Genes harboring DNA methylation alterations were significantly enriched in multiple immune- and disease-related pathways, suggesting the involvement of DNA methylation in regulating host responses to S. aureus subclinical mastitis. In addition, we found nine discriminant signatures (differentiates cows with S. aureus subclinical mastitis from healthy cows) representing the majority of the DNA methylation variations related to S. aureus subclinical mastitis. Validation of seven dMHBs in 200 cows indicated significant associations with mammary gland health (SCC and SCS) and milk production performance (milk yield). Conclusions In conclusion, our findings revealed abundant DNA methylation alterations in milk somatic cells that may be involved in regulating mammary gland defense against S. aureus infection. Particularly noteworthy is the identification of seven dMHBs showing significant associations with mammary gland health, underscoring their potential as promising epigenetic biomarkers. Overall, our findings on DNA methylation alterations offer novel insights into the regulatory mechanisms of bovine subclinical mastitis, providing further avenues for the development of effective control measures. Graphical Abstract

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Epigenetics of Livestock Health, Production, and Breeding

Cited by 2 publications

References 332 publications

MicroRNAs as potential biomarkers for heat stress in livestock

MicroRNAs as potential biomarkers for heat stress in livestock

DNA methylation haplotype block signatures responding to Staphylococcus aureus subclinical mastitis and association with production and health traits

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