Epigenetics: key to improve delayed wound healing in type 2 diabetes

Dubey, Rupal; Prabhakar, Pranav Kumar; Gupta, Jeena

doi:10.1007/s11010-021-04285-0

Cited by 14 publications

(9 citation statements)

References 145 publications

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“…While the exact etiology of PCOS remains incompletely understood, it is widely recognized as a multifactorial condition influenced by genetic, hormonal, and environmental factors. This essay aims to explore the various components of PCOS etiology, including genetic predisposition, hormonal imbalances, and environmental influences [4][5][6][7].…”

Section: Etiology Of Pcosmentioning

confidence: 99%

Unraveling the Complexities of Polycystic Ovarian Syndrome: A Comprehensive Review

Archana Kumari,

Satya Narayan jha

2024

Sumat. Med. J.

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Polycystic Ovarian Syndrome (PCOS) is a complex endocrine disorder affecting reproductive-age women, characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. This comprehensive review delves into the multifaceted nature of PCOS, exploring its etiology, pathophysiology, clinical manifestations, diagnostic criteria, and management strategies. Key topics include the role of insulin resistance and hyperinsulinemia in PCOS pathogenesis, the impact of hormonal imbalances on menstrual irregularities and fertility, and the association of PCOS with metabolic syndrome and cardiovascular risk factors. Furthermore, the review discusses current diagnostic criteria and controversies surrounding PCOS diagnosis, as well as evidence-based approaches to treatment, encompassing lifestyle modifications, pharmacological interventions, and assisted reproductive technologies. By synthesizing current knowledge and emerging research findings, this review aims to provide a comprehensive overview of PCOS for clinicians, researchers, and individuals affected by this prevalent endocrine disorder.

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Section: Etiology Of Pcosmentioning

confidence: 99%

Unraveling the Complexities of Polycystic Ovarian Syndrome: A Comprehensive Review

Archana Kumari,

Satya Narayan jha

2024

Sumat. Med. J.

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“…Chronic nonhealing wounds are a major threat to patients with diabetes since they can lead to limb amputation (215). Diabetic foot ulcer (DFU), is a wound underneath the ankle that usually results from foot deformities, lower extremity vascular disease and diabetic peripheral neuropathy (216,217).…”

Section: The Role Of Epitranscriptomics In Diabetic Woundsmentioning

confidence: 99%

“…Since DFUs also pose huge threats to personal mental health and the domestic and social economy, it is of great importance to promote wound healing for the treatment of this diabetes-related complication. The etiology of DFUs is multifactorial, including an impaired inflammatory response, reepithelialization, granulation formation, angiogenesis and others, and these processes can be affected by genes, the environment, and nutrition (215,219). Substantial evidence has demonstrated that epigenetic regulatory mechanisms (such as histone modifications and DNA methylation) play a pivotal role in epidermal homeostasis and participate in the processes of wound healing (215,220).…”

Section: The Role Of Epitranscriptomics In Diabetic Woundsmentioning

confidence: 99%

Emerging Role of Epitranscriptomics in Diabetes Mellitus and Its Complications

Geng

Yang

2022

Front. Endocrinol.

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Diabetes mellitus (DM) and its related complications are among the leading causes of disability and mortality worldwide. Substantial studies have explored epigenetic regulation that is involved in the modifications of DNA and proteins, but RNA modifications in diabetes are still poorly investigated. In recent years, posttranscriptional epigenetic modification of RNA (the so-called ‘epitranscriptome’) has emerged as an interesting field of research. Numerous modifications, mainly N6-methyladenosine (m6A), have been identified in nearly all types of RNAs and have been demonstrated to have an indispensable effect in a variety of human diseases, such as cancer, obesity, and diabetes. Therefore, it is particularly important to understand the molecular basis of RNA modifications, which might provide a new perspective for the pathogenesis of diabetes mellitus and the discovery of new therapeutic targets. In this review, we aim to summarize the recent progress in the epitranscriptomics involved in diabetes and diabetes-related complications. We hope to provide some insights for enriching the understanding of the epitranscriptomic regulatory mechanisms of this disease as well as the development of novel therapeutic targets for future clinical benefit.

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“…MicroRNAs are small RNA molecules that act as essential regulators in different biological processes, 13 such as cell differentiation and proliferation, apoptosis, and disease development. Substantial evidence supports that miRNAs are involved in the development of DM and its micro‐ and macrovascular complications 14 .…”

Section: Introductionmentioning

confidence: 99%

Resveratrol improves diabetes‐induced cognitive dysfunction in part through the miR‐146a‐5p/TXNIP axis

Zhang²,

Wang

et al. 2023

The Kaohsiung J of Med Scie

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Resveratrol (RSV) has been shown to have a neuroprotective effect in various central nervous system disorders, although the role of RSV in diabetes-induced cognitive dysfunction is still not fully elucidated. Here, we investigated whether RSV improved diabetes-related cognitive dysfunction in vivo and in vitro. We induced a rat diabetic model with a high-fat and high-sucrose diet followed by intraperitoneal injection of streptozotocin and a diabetic neuron cell model by stimulation with high levels of glucose. We observed that RSV improved impairment in spatial learning and memory in the Morris water maze test (MWM) and novel object recognition test (ORT) in diabetic rats. RSV reversed the reduced miR-146a-5p and upregulated thioredoxin-interacting protein (TXNIP) and inhibited the diabetes-induced increase in interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels in vivo and in vitro. RSV also inhibited diabetes-induced endoplasmic reticulum stress (ESR) by reducing ESR-related protein expression in vivo and in vitro. Moreover, inhibition of miR-146a-5p partially abolished the protective effects of RSV in HG-treated primary neurons. Additionally, we used starBase to predict that miR-146a-5p interacts with TXNIP, which we then verified using a luciferase reporter gene assay. We further observed that miR-146a-5p regulates the mRNA and protein expression of TXNIP in vitro, indicating that the miR-146a-5p/TXNIP axis is involved in the regulation of cognitive dysfunction in a rat diabetic model. Collectively, these results demonstrate that RSV plays a neuroprotective role in diabetes-associated cognitive dysfunction at least in part through regulation of the miR-146a-5p/TXNIP axis.

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Epigenetics: key to improve delayed wound healing in type 2 diabetes

Cited by 14 publications

References 145 publications

Unraveling the Complexities of Polycystic Ovarian Syndrome: A Comprehensive Review

Unraveling the Complexities of Polycystic Ovarian Syndrome: A Comprehensive Review

Emerging Role of Epitranscriptomics in Diabetes Mellitus and Its Complications

Resveratrol improves diabetes‐induced cognitive dysfunction in part through the miR‐146a‐5p/TXNIP axis

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